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Cited by 112Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsAdrenal Hormones and Disorders

Mortality in adults with hypopituitarism: a systematic review and meta-analysis

Jasim, Sina, Alahdab, Fares, Ahmed, Ahmed T., Tamhane, Shrikant, Prokop, Larry J., Nippoldt, Todd B., Murad, M. Hassan·2017·Endocrine
DOI 10.1007/s12020-016-1159-3
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Abstract

Purpose Hypopituitarism is a rare disorder with significant morbidity. To study the evidence on the association of premature mortality and hypopituitarism.Methods A comprehensive search of multiple databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus was conducted through August, 2015. Eligible studies that evaluated patients with hypopituitarism and reported mortality estimates were selected following a predefined protocol. Reviewers, independently and in duplicate, extracted data and assessed the risk of bias.Results We included 12 studies (published 1996-2015) that reported on 23,515 patients. Compared to the general population, hypopituitarism was associated with an overall excess mortality (weighted SMR of 1.55; 95 % CI 1.14-2.11), I 2 = 97.8 %, P = 0.000. Risk factors for increased mortality included younger age at diagnosis, female gender, diagnosis of craniopharyngioma, radiation therapy, transcranial surgery, diabetes insipidus and hypogonadism.Conclusion Hypopituitarism may be associated with premature mortality in adults. Risk is particularly higher in women and those diagnosed at a younger age.

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Crossref · 10.1007/s12020-016-1159-3

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  • Left untreated, anterior pituitary deficiencies are associated with decreased health and quality of life.

    “Left untreated, anterior pituitary deficiencies are associated with decreased health and quality of life [55-59].”

    From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [56]

  • Undiagnosed and untreated pituitary deficiencies confer increased morbidity and mortality, which can be reversed by appropriate hormone replacement.

    “undiagnosed and untreated deficiencies confer increased morbidity and mortality, which can be reversed by appropriate hormone replacement.”

    From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [56]

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Authors
Jasim, S., Alahdab, F., Ahmed, A. T., Tamhane, S., Prokop, L. J., Nippoldt, T. B., & Murad, M. H.
Affiliations
Mayo Clinic (US)
Corresponding author
Murad, M. Hassan
ORCID
Venue
Endocrine
Publisher
Springer Science and Business Media LLC
Published
2016-11-05
Volume
56
Issue
1
Pages
33-42
ISSN
  • 0969-711X (ISSN-L)
  • 1355-008X
  • 1559-0100
DOI
10.1007/s12020-016-1159-3
OpenAlex
W2548728043
Cited by
112
References
42
Citations by year
2026: 6 · 2025: 17 · 2024: 14 · 2023: 12 · 2022: 18 · 2021: 12 · 2020: 13 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 1
FWCI
0.93
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (unspecified)
Locations
  • Endocrine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
hypopituitarism, premature mortality, risk factors, craniopharyngioma, radiotherapy, transcranial surgery, diabetes insipidus, hypogonadism, age at diagnosis, sex differences
MeSH terms
Adult, Age Factors, Craniopharyngioma, Female, Humans, Hypopituitarism, Male, Pituitary Neoplasms, Risk Factors, Sex Factors

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