Genetic variation in 11β-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge

Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome

(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050 · see citing works

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)

The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) · Human Reproduction · doi:10.1093/humrep/deh098 · Cited by 6,138 · see citing works

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp

Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621 · see citing works

Clinical assessment of body hair growth in women.

Ferriman, D., & Gallwey, J. D. (1961) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem-21-11-1440 · Cited by 2,556 · see citing works

Polycystic Ovary Syndrome

Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463 · see citing works

A transgenic model of visceral obesity and the metabolic syndrome

Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., & Flier, J. S. (2001) · Science · doi:10.1126/science.1066285 · Cited by 1,766 · see citing works

Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women

Legro, R. S. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.1.165 · Cited by 1,743 · see citing works

11β-Hydroxysteroid dehydrogenase type 1: a tissue specific regulator of glucocorticoid response

Tomlinson, J. W., Walker, E. A., Bujalska, I. J., Draper, N., Lavery, G. G., Cooper, M. S., Hewison, M., & Stewart, P. M. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0031 · Cited by 969 · see citing works

Prevalence and Characteristics of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome

Apridonidze, T., Essah, P. A., Iuorno, M. J., & Nestler, J. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1045 · Cited by 931 · see citing works

Effects of Metformin on Spontaneous and Clomiphene-Induced Ovulation in the Polycystic Ovary Syndrome

Nestler, J. E., Jakubowicz, D. J., Evans, W. S., & Pasquali, R. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806253382603 · Cited by 781 · see citing works

Minireview: 11β-Hydroxysteroid Dehydrogenase Type 1— A Tissue-Specific Amplifier of Glucocorticoid Action1

Seckl, J. R., & Walker, B. R. (2001) · Endocrinology · doi:10.1210/endo.142.4.8114 · Cited by 714 · see citing works

Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome

Pasquali, R., Gambineri, A., Biscotti, D., Vicennati, V., Gagliardi, L., Colitta, D., Fiorini, S., Cognigni, G. E., Filicori, M., & Morselli-Labate, A. M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6738 · Cited by 635 · see citing works

Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

Morton, N. M., Paterson, J. M., Masuzaki, H., Holmes, M. C., Staels, B., Fievet, C., Walker, B. R., Flier, J. S., Mullins, J. J., & Seckl, J. R. (2004) · Diabetes · doi:10.2337/diabetes.53.4.931 · Cited by 512 · see citing works

Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity.

Rask, E., Walker, B., Söderberg, S., Livingstone, D., Eliasson, M., Johnson, O., Andrew, R., & Olsson, T. (2002) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.87.7.8661 · Cited by 467 · see citing works

Improved Lipid and Lipoprotein Profile, Hepatic Insulin Sensitivity, and Glucose Tolerance in 11β-Hydroxysteroid Dehydrogenase Type 1 Null Mice

Morton, N. M., Holmes, M. C., Fiévet, C., Staels, B., Tailleux, A., Mullins, J. J., & Seckl, J. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103676200 · Cited by 441 · see citing works

Repeatability Characteristics of Simple Indices of Insulin Resistance: Implications for Research Applications

Mather, K. J., Hunt, A. E., Steinberg, H. O., Paradisi, G., Hook, G., Katz, A., Quon, M. J., & Baron, A. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.7880 · Cited by 363 · see citing works

Obesity and Gender Influence Cortisol Secretion and Metabolism in Man

Andrew, R., Phillips, D. I. W., & Walker, B. R. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.5.4951 · Cited by 351 · see citing works

Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

Draper, N., Walker, E. A., Bujalska, I. J., Tomlinson, J. W., Chalder, S. M., Arlt, W., Lavery, G. G., Bedendo, O., Ray, D. W., Laing, I., et al. (2003) · Nature Genetics · doi:10.1038/ng1214 · Cited by 285 · see citing works

Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation

Walker, B. R., Connacher, A. A., Lindsay, R. M., Webb, D. J., & Edwards, C. R. W. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.11.7593419 · Cited by 277 · see citing works

Effects of the 11β-Hydroxysteroid Dehydrogenase Inhibitor Carbenoxolone on Insulin Sensitivity in Men with Type 2 Diabetes

Andrews, R. C., Rooyackers, O., & Walker, B. R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021194 · Cited by 266 · see citing works

Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome

Gambineri, A., Pelusi, C., Genghini, S., Morselli‐Labate, A. M., Cacciari, M., Pagotto, U., & Pasquali, R. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.01973.x · Cited by 216 · see citing works

Increased In Vivo Regeneration of Cortisol in Adipose Tissue in Human Obesity and Effects of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor Carbenoxolone

Sandeep, T. C., Andrew, R., Homer, N. Z. M., Andrews, R. C., Smith, K., & Walker, B. R. (2005) · Diabetes · doi:10.2337/diabetes.54.3.872 · Cited by 205 · see citing works

Hyperandrogenism in Polycystic Ovary Syndrome -- Evidence of Dysregulation of 11β-Hydroxysteroid Dehydrogenase

Rodin, A., Thakkar, H., Taylor, N., & Clayton, R. N. (1994) · New England Journal of Medicine · doi:10.1056/nejm199402173300703 · Cited by 191 · see citing works

Glucose Intolerance in a Large Cohort of Mediterranean Women With Polycystic Ovary Syndrome

Gambineri, A., Pelusi, C., Manicardi, E., Vicennati, V., Cacciari, M., Morselli‐Labate, A. M., Pagotto, U., & Pasquali, R. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2353 · Cited by 167 · see citing works

The natural history of the metabolic syndrome in young women with the polycystic ovary syndrome and the effect of long‐term oestrogen–progestagen treatment

Pasquali, R., Gambineri, A., Anconetani, B., Vicennati, V., Colitta, D., Caramelli, E., Casimirri, F., & Morselli‐Labate, A. M. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00701.x · Cited by 157 · see citing works

Abnormalities of the Hypothalamic-Pituitary-Adrenal Axis in Nondepressed Women with Abdominal Obesity and Relations with Insulin Resistance: Evidence for a Central and a Peripheral Alteration

Vicennati, V., & Pasquali, R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6946 · Cited by 146 · see citing works

11?-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle

Nair, S., Lee, Y. H., Lindsay, R. S., Walker, B. R., Tataranni, P. A., Bogardus, C., Baier, L. J., & Permana, P. A. (2004) · Diabetologia · doi:10.1007/s00125-004-1407-6 · Cited by 112 · see citing works

Adrenal androgen excess in hyperandrogenism: relation to age and body mass

Morán, C., Knochenhauer, E. S., Boots, L. R., & Azziz, R. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00536-6 · Cited by 96 · see citing works

Apparent cortisone reductase deficiency: a unique form of hypercortisolism

Phillipov, G., Palermo, M., & Shackleton, C. H. L. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923828 · Cited by 82 · see citing works

A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11β-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome

San Millán, J. L., Botella-Carretero, J. I., Álvarez-Blasco, F., Luque-Ramírez, M., Sancho, J., Moghetti, P., & Escobar-Morreale, H. F. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1523 · Cited by 65 · see citing works

Interaction Between an 11βHSD1 Gene Variant and Birth Era Modifies the Risk of Hypertension in Pima Indians

Franks, P. W., Knowler, W. C., Nair, S., Koška, J., Lee, Y., Lindsay, R. S., Walker, B. R., Looker, H. C., Permana, P. A., Tataranni, P. A., et al. (2004) · Hypertension · doi:10.1161/01.hyp.0000144294.28985.d5 · Cited by 59 · see citing works

Hyperandrogenism in Polycystic Ovary Syndrome

Rodin, A., Thakkar, H., Taylor, N., & Clayton, R. N. (1994) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199407000-00021 · Cited by 51 · see citing works

Genotypes at 11β-Hydroxysteroid Dehydrogenase Type 11B1 and Hexose-6-Phosphate Dehydrogenase Loci Are Not Risk Factors for Apparent Cortisone Reductase Deficiency in a Large Population-Based Sample

White, P. C. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0942 · Cited by 47 · see citing works

Influence of insulin and testosterone on adrenocortical steroidogenesis in vitro: preliminary studies

Hines, G. A., Smith, E. R., & Azziz, R. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02014-3 · Cited by 42 · see citing works

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458 · see citing works

The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited

Rosenfield, R. L., & Ehrmann, D. A. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1104 · Cited by 1,603 · see citing works

11β-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action

Chapman, K., Holmes, M., & Seckl, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00020.2012 · Cited by 887 · see citing works

11β-hydroxysteroid dehydrogenase 1: translational and therapeutic aspects

Gathercole, L. L., Lavery, G. G., Morgan, S. A., Cooper, M. S., Sinclair, A. J., Tomlinson, J. W., & Stewart, P. M. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1050 · Cited by 196 · see citing works

Differential Gene Expression Profile in Omental Adipose Tissue in Women with Polycystic Ovary Syndrome

Cortón, M., Botella-Carretero, J. I., Benguría, A., Villuendas, G., Zaballos, Á., Millán, J. L. S., Escobar-Morreale, H. F., & Peral, B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1665 · Cited by 174 · see citing works

Inhibition of 11ß-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target

Wamil, M., & Seckl, J. R. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.06.001 · Cited by 162 · see citing works

Untitled work

(2007) · doi:10.1139/h06-102 · Cited by 160 · see citing works

Androgens and polycystic ovary syndrome

Nisenblat, V., & Norman, R. J. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832afd4d · Cited by 125 · see citing works

Increased 5α-Reductase Activity and Adrenocortical Drive in Women with Polycystic Ovary Syndrome

Vassiliadi, D. A., Barber, T. M., Hughes, B. A., McCarthy, M. I., Wass, J. A. H., Franks, S., Nightingale, P., Tomlinson, J. W., Arlt, W., & Stewart, P. M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0837 · Cited by 110 · see citing works

Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome

de Medeiros, S. F., Rodgers, R. J., & Norman, R. J. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab004 · Cited by 107 · see citing works

Cyp11b1 Is Induced in the Murine Gonad by Luteinizing Hormone/Human Chorionic Gonadotropin and Involved in the Production of 11-Ketotestosterone, a Major Fish Androgen: Conservation and Evolution of the Androgen Metabolic Pathway

Yazawa, T., Uesaka, M., Inaoka, Y., Mizutani, T., Sekiguchi, T., Kajitani, T., Kitano, T., Umezawa, A., & Miyamoto, K. (2007) · Endocrinology · doi:10.1210/en.2007-1015 · Cited by 95 · see citing works

The Role of Genetics, Epigenetics and Lifestyle in Polycystic Ovary Syndrome Development: the State of the Art

Bruni, V., Capozzi, A., & Lello, S. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00515-4 · Cited by 98 · see citing works

Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity

Roberge, C., Carpentier, A. C., Langlois, M., Baillargeon, J., Ardilouze, J., Maheux, P., & Gallo‐Payet, N. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00516.2007 · Cited by 87 · see citing works

Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II

Feigelson, H. S., Teras, L. R., Diver, W. R., Tang, W., Patel, A. V., Stevens, V. L., Calle, E. E., Thun, M. J., & Bouzyk, M. (2008) · Breast Cancer Research · doi:10.1186/bcr2114 · Cited by 61 · see citing works

HSD11B1 polymorphisms predicted bone mineral density and fracture risk in postmenopausal women without a clinically apparent hypercortisolemia

Hwang, J.-Y., Lee, S. H., Kim, G. S., Koh, J.-M., Go, M. J., Kim, Y.-J., Kim, H.-C., Kim, T.-H., Hong, J. M., Park, E. K., et al. (2009) · Bone · doi:10.1016/j.bone.2009.07.080 · Cited by 55 · see citing works

Extra-adrenal regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning

Walker, B. R. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s002966510700523x · Cited by 54 · see citing works

The Adrenal Cortex and its Disorders

Miller, W. L. (2009) · Wiley eBooks · doi:10.1002/9781444316728.ch13 · Cited by 51 · see citing works

The role of genes in the polycystic ovary syndrome: Predisposition and mechanisms

Deligeoroglou, E., Kouskouti, C., & CHRISTOPOULOS, P. F. (2009) · Gynecological Endocrinology · doi:10.1080/09513590903015619 · Cited by 50 · see citing works

A combination of polymorphisms in HSD11B1 associates with in vivo 11β-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome

Gambineri, A., Tomassoni, F., Munarini, A., Stimson, R. H., Mioni, R., Pagotto, U., Chapman, K. E., Andrew, R., Mantovani, V., Pasquali, R., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0091 · Cited by 47 · see citing works

Urinary steroid profiling in women hints at a diagnostic signature of the polycystic ovary syndrome: A pilot study considering neglected steroid metabolites

Dhayat, N. A., Marti, N., Kollmann, Z., Troendle, A., Bally, L., Escher, G., Groessl, M., Ackermann, D., Ponte, B., Pruijm, M. T., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203903 · Cited by 46 · see citing works

Pathophysiological mechanisms of gonadotropins- and steroid hormones-related genes in etiology of polycystic ovary syndrome.

Shaaban, Z., Khoradmehr, A., Shirazi, M. R. J., & Tamadon, A. (2019) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2018.31776.7646 · Cited by 41 · see citing works

Emerging role of GIP and related gut hormones in fertility and PCOS

Moffett, R. C., & Naughton, V. R. (2020) · Peptides · doi:10.1016/j.peptides.2019.170233 · Cited by 41 · see citing works

Genes for Enzymes Regulating Dehydroepiandrosterone Sulfonation Are Associated with Levels of Dehydroepiandrosterone Sulfate in Polycystic Ovary Syndrome

Goodarzi, M. O., Antoine, H. J., & Azziz, R. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2600 · Cited by 38 · see citing works

Cardiometabolic abnormalities in the polycystic ovary syndrome: Pharmacotherapeutic insights

Westerveld, H. E., Hoogendoorn, M., de Jong, A. W. F., Goverde, A. J., Fauser, B. C. J. M., & Dallinga‐Thie, G. M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.04.009 · Cited by 38 · see citing works

Influence of adrenal hyperandrogenism on the clinical and metabolic phenotype of women with polycystic ovary syndrome

Alpañés, M., Luque‐Ramírez, M., Martínez-García, M. Á., Fernández‐Durán, E., Álvarez‐Blasco, F., & Escobar-Morreale, H. F. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.12.105 · Cited by 38 · see citing works

Association of CYP3A7*1C and Serum Dehydroepiandrosterone Sulfate Levels in Women with Polycystic Ovary Syndrome

Goodarzi, M. O., Xu, N., & Azziz, R. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0403 · Cited by 33 · see citing works

Association study of CYP17 and HSD11B1 in polycystic ovary syndrome utilizing comprehensive gene coverage

Chua, A. K., Azziz, R., & Goodarzi, M. O. (2012) · Molecular Human Reproduction · doi:10.1093/molehr/gas002 · Cited by 32 · see citing works

Expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in subcutaneous adipose tissue of lean and obese women with and without polycystic ovary syndrome

Svendsen, P. F., Madsbad, S., Nilas, L., Paulsen, S. K., & Pedersen, S. B. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.165 · Cited by 31 · see citing works

Genetic Polymorphisms in 11β-Hydroxysteroid Dehydrogenase Type 1 Correlate With the Postdexamethasone Cortisol Levels and Bone Mineral Density in Patients Evaluated for Osteoporosis

Siggelkow, H., Etmanski, M., Bozkurt, S., Groβ, P., Koepp, R., Brockmöller, J., & Tzvetkov, M. V. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1418 · Cited by 29 · see citing works

The Adrenal Cortex and Its Disorders

Miller, W. L., Achermann, J. C., & Flück, C. E. (2008) · Elsevier eBooks · doi:10.1016/b978-141604090-3.50017-x · Cited by 28 · see citing works

Evidence for Involvement of GIP and GLP-1 Receptors and the Gut-Gonadal Axis in Regulating Female Reproductive Function in Mice

Khan, D., Ojo, O. O., Woodward, O. R. M., Lewis, J. E., Sridhar, A., Gribble, F. M., Reimann, F. M., Flatt, P. R., & Moffett, R. C. (2022) · Biomolecules · doi:10.3390/biom12121736 · Cited by 27 · see citing works

Lack of Association of the 11β-Hydroxysteroid Dehydrogenase Type 1 Gene 83,557insA and Hexose-6-Phosphate Dehydrogenase Gene R453Q Polymorphisms with Body Composition, Adrenal Androgen Production, Blood Pressure, Glucose Metabolism, and Dementia

Smit, P., Dekker, M. J. H. J., de Jong, F. J., van den Beld, A. W., Koper, J. W., Pols, H. A. P., Brinkmann, A. O., de Jong, F. H., Breteler, M. M. B., & Lamberts, S. W. J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1349 · Cited by 27 · see citing works

Variants in SULT2A1 Affect the DHEA Sulphate to DHEA Ratio in Patients With Polycystic Ovary Syndrome But Not the Hyperandrogenic Phenotype

Louwers, Y. V., de Jong, F. H., van Herwaarden, N. A. A., Stolk, L., Fauser, B. C. J. M., Uitterlinden, A. G., & Laven, J. S. E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1976 · Cited by 26 · see citing works

Functional Effects of Polymorphisms in the Human Gene Encoding 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1): A Sequence Variant at the Translation Start of 11β-HSD1 Alters Enzyme Levels

Malavasi, E. L. V., Kelly, V., Nath, N., Gambineri, A., Dakin, R. S., Pagotto, U., Pasquali, R., Walker, B. R., & Chapman, K. E. (2009) · Endocrinology · doi:10.1210/en.2009-0663 · Cited by 24 · see citing works

Ovarian 11β-Hydroxysteroid Dehydrogenase (11βHSD) Activity Is Suppressed in Women With Anovulatory Polycystic Ovary Syndrome (PCOS): Apparent Role for Ovarian Androgens

Michael, A. E., Glenn, C., Wood, P. J., Webb, R. J., Pellatt, L. J., & Mason, H. D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1385 · Cited by 24 · see citing works

The rs4844880 polymorphism in the promoter region of the HSD11B1 gene associates with bone mineral density in healthy and postmenopausal osteoporotic women

Feldman, K., Szappanos, Á., Butz, H., Grolmusz, V. K., Majnik, J., Likó, I., Kriszt, B., Lakatos, P. L., Tóth, M., Rácz, K., et al. (2012) · Steroids · doi:10.1016/j.steroids.2012.08.014 · Cited by 23 · see citing works

Cortisol-Metabolizing Enzymes in Polycystic Ovary Syndrome

Blumenfeld, Z., Kaidar, G., Zuckerman‐Levin, N., Dumin, E., Knopf, C. F., & Hochberg, Z. (2016) · Clinical Medicine Insights Reproductive Health · doi:10.4137/cmrh.s35567 · Cited by 22 · see citing works

Bilateral Adrenal Hyperplasia as a Possible Mechanism for Hyperandrogenism in Women With Polycystic Ovary Syndrome

Gourgari, E., Lodish, M. B., Keil, M. F., Sinaii, N., Turkbey, E. B., Lyssikatos, C., Nesterova, M., Sierra, M. D. L. L., Xekouki, P., Khurana, D., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-4019 · Cited by 21 · see citing works

Cortisol and polycystic ovarian syndrome – a systematic search and meta-analysis of case–control studies

Benjamin, J. J., Kuppusamy, M., Koshy, T., Narayanasa, M. K., & Ramaswamy, P. (2021) · Gynecological Endocrinology · doi:10.1080/09513590.2021.1908254 · Cited by 20 · see citing works

Cortisol and the polycystic ovary syndrome

Pasquali, R., & Gambineri, A. (2012) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.12.42 · Cited by 20 · see citing works

Adrenarche and Polycystic Ovary Syndrome: A Tale of Two Hypotheses

Nader, S. (2007) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2007.05.001 · Cited by 19 · see citing works

Polymorphisms of POR, SULT2A1 and HSD11B1 in children with premature adrenarche

Utriainen, P., Laakso, S. M., Jääskeläinen, J., & Voutilainen, R. (2012) · Metabolism · doi:10.1016/j.metabol.2012.02.008 · Cited by 18 · see citing works

Adrenal steroids and the metabolic syndrome

Thomson, S. P., Stump, C. S., Kurukulasuriya, L. R., & Sowers, J. R. (2007) · Current Hypertension Reports · doi:10.1007/s11906-007-0093-4 · Cited by 17 · see citing works

Transcriptomic screening to identify hub genes and drug signatures for PCOS based on RNA-Seq data in granulosa cells

Zanjirband, M., Baharlooie, M., Safaeinejad, Z., & Nasr‐Esfahani, M. H. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106601 · Cited by 18 · see citing works

Correlation of adrenocorticotropin steroid levels between women with polycystic ovary syndrome and their sisters

Goodarzi, M. O., Guo, X., Yıldız, B. O., Stanczyk, F. Z., & Azziz, R. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.12.009 · Cited by 17 · see citing works

Hyperandrogenism, Hirsutism, and Polycystic Ovary Syndrome

Rosenfield, R. L., Barnes, R. B., & Ehrmann, D. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00133-5 · Cited by 17 · see citing works

Fat feeding potentiates the diabetogenic effect of dexamethasone in Wistar rats

Sivabalan, S., Renuka, S., & Menon, V. P. (2008) · International Archives of Medicine · doi:10.1186/1755-7682-1-7 · Cited by 17 · see citing works

The R453Q and D151A polymorphisms of Hexose-6-Phosphate Dehydrogenase Gene (H6PD) influence the polycystic ovary syndrome (PCOS) and obesity

Martínez-García, M. Á., San‐Millán, J. L., & Escobar-Morreale, H. F. (2012) · Gene · doi:10.1016/j.gene.2012.01.047 · Cited by 16 · see citing works

Hydrohysteroid Dehydrogenases – Biological Role and Clinical Importance – Review

Atanassova, N. N., & Koev, Y. (2012) · InTech eBooks · doi:10.5772/54149 · Cited by 16 · see citing works

Impact of HSD11B1 polymorphisms on BMI and components of the metabolic syndrome in patients receiving psychotropic treatments

Quteineh, L., Vandenberghe, F., Saigí-Morgui, N., Delacrétaz, A., Choong, E., Gholam‐Rezaee, M., Magistretti, P. J., Bondolfi, G., von Gunten, A., Preisig, M., et al. (2015) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000131 · Cited by 14 · see citing works

Anormalidades metabólicas em mulheres com síndrome dos ovários policísticos: obesas e não obesas

Romano, L. G. M., Bedoschi, G., de Melo, A. S., de Albuquerque, F. O., Silva, A. C. J. D. S. R. E., Ferriani, R. A., & Navarro, P. A. (2011) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1590/s0100-72032011000600008 · Cited by 14 · see citing works

The 83,557insA variant of the gene coding 11β-hydroxysteroid dehydrogenase type 1 enzyme associates with serum osteocalcin in patients with endogenous Cushing's syndrome

Szappanos, Á., Patócs, A., Gergics, P., Bertalan, R. Á., Kerti, A., Ács, B., Feldman, K., Rácz, K., & Tóth, M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.11.009 · Cited by 13 · see citing works

Role of 11β HSD 1, rs12086634, and rs846910 single-nucleotide polymorphisms in metabolic-related skin diseases: a clinical, biochemical, and genetic study

Farag, A. G. A., Badr, E. A. E., Eltorgoman, A. M. A., Assar, M. F., Elshafey, E. N., Tayel, N. R., & Aboutaleb, H. E. (2019) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s193156 · Cited by 12 · see citing works

Androgens and polycystic ovary syndrome

Alpañés, M., Fernández‐Durán, E., & Escobar-Morreale, H. F. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.11.85 · Cited by 12 · see citing works

11β-hydroxystéroïde déshydrogénases. Avancées récentes

Vantyghem, M., Marcelli-Tourvieille, S., Defrance, F., & Wémeau, J.-L. (2007) · Annales d Endocrinologie · doi:10.1016/j.ando.2007.02.003 · Cited by 12 · see citing works

Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome

Μacut, D., Milutinović, D. V., Antić, I. B., Matić, G. M., Brkljačić, J. M., Panidis, D., Petakov, M. S., Spanos, N., Bjekić, J., Stanojlović, O. P., et al. (2009) · Endocrine · doi:10.1007/s12020-009-9277-9 · Cited by 10 · see citing works

[Women with polycystric ovary syndrome have a higher frequency of metabolic syndrome regardless of body mass index].

de Melo, A. S., Macedo, C. S. V., Romano, L. G. M., Ferriani, R. A., & Navarro, P. A. D. A. S. (2012) · PubMed · Cited by 9 · see citing works

Perfil metabólico em mulheres de diferentes índices de massa corporal com síndrome dos ovários policísticos

de Sousa, R. M. L., Chein, M. B. D. C., da Silva, D. S. M., Dutra, M. B., Navarro, P. A., Neto, J. A. D. F., & Brito, L. M. O. (2013) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1590/s0100-72032013000900006 · Cited by 9 · see citing works

Association of HSD11B1 rs12086634 and HSD11B1 rs846910 gene polymorphisms with polycystic ovary syndrome in South Indian women

Devang, N., Satyamoorthy, K., Rai, P. S., Nandini, M., Basu, A., & Adhikari, P. (2017) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-017-0596-8 · Cited by 8 · see citing works

Genetic variants of the HSD11B1 gene promoter may be protective against polycystic ovary syndrome

Grolmusz, V. K., Ács, O. D., Feldman, K., Szappanos, Á., Stenczer, B., Fekete, T., Szendei, G., Reismann, P., Rácz, K., & Patócs, A. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3473-2 · Cited by 7 · see citing works

Intergenerational Hyperglycemia Impairs Mitochondrial Function and Follicular Development and Causes Oxidative Stress in Rat Ovaries Independent of the Consumption of a High-Fat Diet

Paula, V. G., Sinzato, Y. K., Gallego, F. Q., da Cruz, L. L., de Aquino, A. M., Scarano, W. R., Corrente, J. E., Volpato, G. T., & Damasceno, D. C. (2023) · Nutrients · doi:10.3390/nu15204407 · Cited by 6 · see citing works

Polymorphic variants of the HSD11B1 gene may be involved in adverse metabolic effects of glucocorticoid replacement therapy in Addison's disease

Fichna, M., Żurawek, M., Gryczyńska, M., Sowińska, A., Nowak, J., & Ruchała, M. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.03.027 · Cited by 6 · see citing works

Can the source of hyperandrogenism in adolescents with polycystic ovary syndrome predict metabolic phenotype?

Nofal, A. A., Viers, L. D., & Javed, A. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1342236 · Cited by 6 · see citing works

Differential activity of the corticosteroidogenic enzymes in normal cycling women and women with polycystic ovary syndrome

Yamamoto, M. M. W., & de Medeiros, S. F. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09482-3 · Cited by 6 · see citing works

Hyperandrogenism, Hirsutism, and Polycystic Ovary Syndrome

Barnes, R. B., Ehrmann, D. A., & Rosenfield, R. L. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00132-5 · Cited by 6 · see citing works

Importance of the 11β-hydroxysteroid dehydrogenase enzyme in clinical disorders

Feldman, K., Likó, I., Nagy, Z., Szappanos, Á., Grolmusz, V. K., Tóth, M., Rácz, K., & Patócs, A. (2013) · Orvosi Hetilap · doi:10.1556/oh.2013.29558 · Cited by 5 · see citing works

Gas chromatography-mass spectrometry-based metabolic profiling of androgens, progestins and glucocorticoids in women with polycystic ovary syndrome

Vorokhobina, N. V., Великанова, Л. И., Glavnova, O. B., Валерьевна, М. Е., Камильевна, Г. Р., & Matezius, I. Y. (2020) · Journal of obstetrics and women s diseases · doi:10.17816/jowd69527-38 · Cited by 3 · see citing works

Genes for Enzymes Regulating DHEA Sulfonation are Associated with Levels of DHEA-Sulfate in Polycystic Ovary Syndrome 1

Goodarzi, M. O., Antoine, H. J., & Azziz, R. (2007) · Cited by 3 · see citing works

ACTH stimulation test in lean polycystic ovary syndrome patients with insulin resistance

Uncu, G., Özyürek, E. Ş., & Uncu, Y. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.011 · Cited by 2 · see citing works

Association of polymorphisms of HSD11B1 and ACE genes with trachoma disease

Valdez-Velázquez, L. L., Ochoa‐Díaz‐López, H., Delgado‐Enciso, I., Rangel‐Villalobos, H., Rodriguez-Sanchez, I. P., García-Miranda, R., Velázquez-Ramírez, D. D., REYES-MÉNDEZ, N. A., Barajas-Saucedo, C. E., & Martínez‐Fierro, M. L. (2024) · Journal of Genetics · doi:10.1007/s12041-024-01474-w · Cited by 1 · see citing works

Correlation between Serum Dehydroepiandrosterone Sulfate and LDL Cholesterol in Patients with Polycystic Ovarian Syndrome

Gunawan, H., Ipandi, I., Nugraha, J., & Sa’adi, A. (2020) · INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY · doi:10.24293/ijcpml.v27i1.1600 · Cited by 1 · see citing works

The effects of ovarian enzyme modulators on folliculogenesis and cyst development in the porcine ovary.

Sunak, N. (2007) · OpenGrey (Institut de l'Information Scientifique et Technique) · Cited by 1 · see citing works

Recherche de déterminants génétiques des phénotypes associés au syndrome métabolique en population

Legry, V. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

and onset of obesity

Roberge, C., Carpentier, A. C., Langlois, M., Baillargeon, J., Ardilouze, J., & Gallo‐Payet, N. (2007)

Genetic Variation in 11β-Hydroxysteroid Dehydrogenase Type 1 Predicts Adrenal Hyperandrogenism among Lean Women with Polycystic Ovary Syndrome

Meikle, A. W. (2007) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)70199-9

A combination of polymorphisms in HSD11B1 associates with in vivo 11β-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome

Gambineri, A., Tomassoni, F., Munarini, A., Stimson, R. H., Mioni, R., Pagotto, U., Chapman, K. E., Andrew, R., Mantovani, V., Pasquali, R., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0091 · Cited by 47 · see citing works

Tissue-specific dysregulation of 11β-hydroxysteroid dehydrogenase type 1 in overweight/obese women with polycystic ovary syndrome compared with weight-matched controls

Gambineri, A., Fanelli, F., Tomassoni, F., Munarini, A., Pagotto, U., Andrew, R., Walker, B. R., & Pasquali, R. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-1030 · Cited by 30 · see citing works

Association of HSD11B1 rs12086634 and HSD11B1 rs846910 gene polymorphisms with polycystic ovary syndrome in South Indian women

Devang, N., Satyamoorthy, K., Rai, P. S., Nandini, M., Basu, A., & Adhikari, P. (2017) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-017-0596-8 · Cited by 8 · see citing works

Increased clearance of cortisol by 5β-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome

Gambineri, A., Forlani, G., Munarini, A., Tomassoni, F., Cognigni, G. E., Ciampaglia, W., Pagotto, U., Walker, B. R., & Pasquali, R. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03346454 · Cited by 28 · see citing works

Expression of 11β-hydroxysteroid dehydrogenase type 1 in visceral and subcutaneous adipose tissues of patients with polycystic ovary syndrome is associated with adiposity

Mlinar, B., Marc, J., Jensterle, M., Bokal, E. V., Jerin, A., & Pfeifer, M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.12.002 · Cited by 20 · see citing works