The DOI matches its Crossref record; 50 of the 54 references it cites were found in a registry or an index.
Prognostic Parameters of Metastatic Adrenocortical Carcinoma
Abstract
CONTEXT: Prognostic parameters of metastatic adrenocortical carcinoma (ACC) are poorly characterized. OBJECTIVE: The objective of the study was to describe the clinical presentation of metastatic ACC and determine prognostic factors for survival. DESIGN: This was a retrospective cohort study (1988-2004). SETTING: The study was conducted in an institutional practice. PATIENTS: Participants included 124 consecutive patients with metastatic ACC, 70 from Gustave-Roussy Institute (main cohort) and 54 patients from the Cochin Hospital (validation cohort). Clinical data concerning all patients, histopathologic slides of primary tumors (44 in the main cohort and 40 in the validation cohort), and molecular biology data on 15 primary tumors (main cohort) were analyzed. INTERVENTION: There was no intervention. MAIN OUTCOME: The main outcome was the specific survival after discovery of the first metastasis (Kaplan-Meier method). This included univariate analysis on the main cohort, confirmed on the validation cohort and then analyzed in a multivariate analysis. RESULTS: In the main cohort, overall median survival was 20 months. In univariate analysis, the presence of hepatic and bone metastases, the number of metastatic lesions and the number of tumoral organs at the time of the first metastasis, a high mitotic rate (>20 per 50 high-power field), and atypical mitoses in the primary tumor predicted survival (P = 0.05, 0.003, 0.046, 0.001, 0.01, and < 0.001, respectively). The number of tumoral organs and a high mitotic rate were confirmed on the validation cohort (P = 0.009 and 0.03, respectively). These two parameters were confirmed in multivariate analysis (P = 0.0058 and 0.049). CONCLUSION: Metastatic ACC is a heterogeneous disease with poor outcome. The combination of the number of tumoral organs at the time of the first metastasis and the mitotic rate can predict different outcomes.
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In the citing paper
“Tumor extent (eg, stage), specifically the presence of distant metastasis and number of organs involved in metastatic disease, confers a worse prognosis (243, 244).”
From Adrenocortical carcinoma (2014) · cites this paper as [243]
In the citing paper
“Naturally, age at diagnosis is correlated with decreased overall survival (243).”
From Adrenocortical carcinoma (2014) · cites this paper as [243]
In the citing paper
“Tumor grade influences the decision for reoperation because it correlates with survival (243, 245).”
From Adrenocortical carcinoma (2014) · cites this paper as [243]
In the citing paper
“The number of organs involved by tumor at the time of the first metastasis is a predictor of survival (243, 265).”
From Adrenocortical carcinoma (2014) · cites this paper as [243]
Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J., & Smith, P. G. (1977) · British Journal of Cancer · doi:10.1038/bjc.1977.1 · Cited by 8,285
Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors
Weiss, L. M. (1984) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198403000-00001 · Cited by 920 · cited 2×
“Atypical mitoses have also been considered as a significant diagnostic parameter in a one-score pathological system (37), associated with a low disease-free survival in a univariate analysis in another study (12), and identified as an important predictor of malignancy in childhood adrenocortical tumors (41).”
BackgroundMethodPathologic features of prognostic significance in adrenocortical carcinoma
Weiss, L. M., Medeiros, L. J., & Vickery, A. L. (1989) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198903000-00004 · Cited by 818 · cited 2×
“From a prognostic point of view, the mitotic index or the Ki-67 staining index has emerged as single parameters correlated with survival in various studies (11, 12, 17, 19, 39, 40).”
BackgroundMethodAdrenocortical Carcinoma: Clinical Update
Allolio, B., & Fassnacht, M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2639 · Cited by 775
Luton, J.-P., Cerdas, S., Billaud, L., Thomas, G., Guilhaume, B., Bertagna, X., Laudat, M.-H., Louvel, A., Chapuis, Y., Blondeau, P., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004263221705 · Cited by 717
Self-citationIcard, P., Goudet, P., Charpenay, C., Andreassian, B., Carnaille, B., Chapuis, Y., Cougard, P., Henry, J., & Proye, C. (2001) · World Journal of Surgery · doi:10.1007/s00268-001-0047-y · Cited by 543
Cited by
Sorted by citations
Faßnacht, M., Dekkers, O. M., Else, T., Baudin, É., Berruti, A., de Krijger, R. R., Haak, H. R., Mihai, R., Assié, G., & Terzolo, M. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0608 · Cited by 976
Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892
Combination Chemotherapy in Advanced Adrenocortical Carcinoma
Faßnacht, M., Terzolo, M., Allolio, B., Baudin, É., Haak, H. R., Berruti, A., Welin, S., Schade‐Brittinger, C., Lacroix, A., Jarząb, B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200966 · Cited by 874
Self-citationFassnacht, M., Johanssen, S., Quinkler, M., Bucsky, P., Willenberg, H. S., Beuschlein, F., Terzolo, M., Mueller, H., Hahner, S., Allolio, B., et al. (2009) · Cancer · doi:10.1002/cncr.24030 · Cited by 695
Update in Adrenocortical Carcinoma
Faßnacht, M., Kroiß, M., & Allolio, B. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3020 · Cited by 414
Metadata
- Authors
- Assié, G., Antoni, G., Tissier, F., Caillou, B., Abiven, G., Gicquel, C., Leboulleux, S., Travagli, J.-P., Dromain, C., Bertagna, X., Bertherat, J., Schlumberger, M., & Baudin, E.
- Affiliations
- Service de Médecine Nucléaire et de Cancérologie Endocrinienne (G.As., S.L., J.-P.T., C.D., M.S., E.B.), Institut Gustave-Roussy, Université Paris XI, 94800 Villejuif, France
- Institut Gustave Roussy (FR)
- Département d’Anatomo-Pathologie (F.T.), Hôpital Cochin, Université Paris V René Descartes, Faculté de Médécine, Site Cochin-Port-Royal, 75014 Paris, France
- Hôpital Cochin (FR)
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Service d’Endocrinologie (G.Ab., X.B., J.B.), Hôpital Cochin, Université Paris V René Descartes, Faculté de Médécine, Site Cochin-Port-Royal, 75014 Paris, France
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2007-01-01
- Volume
- 92
- Issue
- 1
- Pages
- 148-154
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2114699004
- Cited by
- 236
- References
- 54
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 13 · 2023: 14 · 2022: 10 · 2021: 18 · 2020: 10 · 2019: 16 · 2018: 13 · 2017: 8 · 2016: 7 · 2015: 14 · 2014: 18 · 2013: 11 · 2012: 11
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Oncology › Renal cell carcinoma treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- metastatic adrenocortical carcinoma, prognostic factors, survival, mitotic activity, atypical mitoses, liver metastasis, bone metastasis, number of metastatic lesions, clinical features
- MeSH terms
- Adolescent, Adrenal Cortex Neoplasms, Adult, Aged, Bone Neoplasms, Female, Humans, Liver Neoplasms, Male, Middle Aged, Prognosis, Retrospective Studies, Cohort Studies, Survival Rate, Multivariate Analysis, Loss of Heterozygosity
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