CoChat
Sign Up
Cited by 79Neuroendocrine Tumor Research AdvancesPancreatic function and diabetesDiabetes Management and Research

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Insulinomas may present with normoglycemia after prolonged fasting but glucose-stimulated hypoglycemia.

Kar, Partha, Price, Paul, Sawers, Stewart, Bhattacharya, Satya, Reznek, Rodney H., Grossman, Ashley B.·2006·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2006-1430
Open this paper in CoChat — free account

Abstract

Background: Insulinomas are rare but are the most common cause of hyperinsulinemic hypoglycemia in the adult population. Diagnosis of this pathology relies on clinical features along with laboratory tests and imaging investigations to aid in localization. One of the most robust standard tests used for establishing a biochemical diagnosis is the prolonged (72 h) fast. Currently, it is recommended that a prolonged supervised fast be performed, at least for 48 h if not for 72 h, and many would take the absence of hypoglycemia after a 72-h fast as evidence excluding the diagnosis. Methods: We employed prolonged fasts and standard glucose tolerance tests, plus imaging studies and surgical pathology, in two patients with suspected insulinomas. Results: The prolonged 72-h fast was normal in both the patients, whereas in both cases a prolonged oral glucose tolerance test clearly demonstrated the induction of severe hyperinsulinemia followed by significant hypoglycemia. Surgical removal confirmed the presence of insulinomas in each case. Conclusions: Although the sensitivity of the 72-h fast is high and still plays an important role in the diagnosis of an insulinoma, we suggest that a “normal” test result should be interpreted in the light of clinical symptoms.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1210/jc.2006-1430

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Insulinoma is characterized by spells of neuroglycopenia due to endogenous hyperinsulinemic hypoglycemia occurring primarily in the fasting state but occasionally only in the postprandial period.

    “Clinically, insulinoma is characterized by spells of neuroglycopenia due to endogenous hyperinsulinemic hypoglycemia occurring primarily in the fasting state but occasionally only in the postprandial period (23,38,39).”

    From Evaluation and Management of Adult Hypoglycemic Disorders: An Endocrine Society Clinical Practice Guideline (2009) · cites this paper as [38]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Scholz, 1960, Hyperinsulinism: review of 95 cases of functioning pancreatic islet cell tumors, Mayo Clinic Proc, 35, 545

Cited by

Sorted by citations

Related

Metadata

Authors
Kar, P., Price, P., Sawers, S., Bhattacharya, S., Reznek, R. H., & Grossman, A. B.
Affiliations
  • Great Western Hospital (GB)
  • National Health Service (GB)
  • Department of Medicine (P.K., P.P.), Great Western Hospital, Swindon SN1 4JU, United Kingdom
  • Barts Health NHS Trust (GB)
  • Departments of Endocrinology (A.B.G.), Hepatobiliary Surgery (S.B.) London EC1A 7BE, United Kingdom
Corresponding author
Grossman, Ashley B.
ORCID
Grossman, Ashley B.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2006-12-01
Volume
91
Issue
12
Pages
4733-4736
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2006-1430
OpenAlex
W2031158920
Semantic Scholar
eae24db3cf496e966ec6516e4817fe575e25a056
Cited by
79
References
27
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 3 · 2013: 7 · 2012: 5
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
insulinoma, hyperinsulinemic hypoglycemia, prolonged fasting, oral glucose tolerance test, hyperinsulinemia, diagnostic sensitivity
MeSH terms
Adult, Aged, Blood Glucose, Fasting, Glucose Tolerance Test, Humans, Hypoglycemia, Insulin, Insulinoma, Male, Pancreatic Neoplasms, Tomography, X-Ray Computed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review