The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
Associations of Adiponectin, Resistin, and Tumor Necrosis Factor-α with Insulin Resistance
Open accessAbstract
CONTEXT: Adipose tissue-derived adipokines may contribute to insulin resistance. OBJECTIVE: We tested the hypothesis that adipokines are associated with insulin resistance in a community-based cohort and that associations are maintained in people with and without the metabolic syndrome (high vs. low risk of diabetes). DESIGN, SETTING, AND PARTICIPANTS: We studied a cross-sectional sample of 2356 individuals attending the seventh examination (1998-2001) of the Framingham Offspring Study. We measured levels of glucose, insulin, adiponectin, resistin, and TNFalpha in fasting blood samples and defined metabolic syndrome by updated National Cholesterol Education Program criteria. We used ANOVA to test associations of adipokines with insulin resistance and multivariable logistic regression models to assess joint associations of adipokines and metabolic syndrome with insulin resistance. MAIN OUTCOME MEASURE: Homeostasis model (HOMA-IR), with insulin resistance defined by HOMA-IR greater than the 75th percentile, was measured. RESULTS: Age- and sex-adjusted HOMA-IR levels were inversely related to adiponectin (r = -0.40, P < 0.0001) and positively related to resistin (r = 0.13, P < 0.0001) and TNFalpha (r = 0.12, P < 0.0001). The prevalence of insulin resistance increased with decreasing tertiles of adiponectin (from 10.9% in the third to 42.5% in the first tertile; P < 0.0001) and increasing tertiles of resistin (from 19.3 to 30.9%; P < 0.0001) and TNFalpha (from 18.8 to 32.0%; P < 0.0001). Results were similar after adjustment for body mass index. These associations were present in individuals with or without the metabolic syndrome. In multivariable regression models, metabolic syndrome and adipokines individually and jointly were significantly associated with insulin resistance. CONCLUSION: Adverse levels of adipokines are associated with insulin resistance in individuals at low or high diabetes risk.
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“In humans, plasma adiponectin levels correlated negatively with insulin resistance, and higher levels correlated with future weight gain in 1,063 women.63,64”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [63]
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Obesity is associated with macrophage accumulation in adipose tissue
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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
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The hormone resistin links obesity to diabetes
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Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Manna, P., & Jain, S. K. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0095 · Cited by 1,211
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Adipokines and Insulin Resistance
Rabe, K., Lehrke, M., Parhofer, K. G., & Broedl, U. C. (2008) · Molecular Medicine · doi:10.2119/2008-00058.rabe · Cited by 828
Adipocytokines and the Metabolic Complications of Obesity
Rasouli, N., & Kern, P. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1613 · Cited by 751
Metadata
- Authors
- Hivert, M.-F., Sullivan, L. M., Fox, C. S., Nathan, D. M., D’Agostino, R. B., Wilson, P. W. F., & Meigs, J. B.
- Affiliations
- Massachusetts General Hospital (US)
- Boston University (US)
- Harvard University (US)
- Emory University (US)
- Corresponding author
- Meigs, James B.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-08-01
- Volume
- 93
- Issue
- 8
- Pages
- 3165-3172
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC2515087
- OpenAlex
- W2035812981
- Cited by
- 262
- References
- 45
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 10 · 2023: 5 · 2022: 10 · 2021: 10 · 2020: 14 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 25 · 2014: 20 · 2013: 24 · 2012: 24
- FWCI
- 18.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- U.S. Public Health Service (K24 DZK080140)
- National Heart, Lung, and Blood Institute (N01‐HC25195, N01-HC-025195)
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK080140)
- National Center for Research Resources (M01RR001066, M01-RR01066)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- insulin resistance, adiponectin, resistin, TNF-α, adipokines, metabolic syndrome, type 2 diabetes risk, HOMA-IR, adipose tissue, Framingham Offspring Study
- MeSH terms
- Aged, Cross-Sectional Studies, Female, Humans, Insulin Resistance, Male, Middle Aged, Tumor Necrosis Factor-alpha, Body Mass Index, Logistic Models, Adiponectin, Resistin
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