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Cited by 243Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsNutrition and Health in Aging

Low Serum Testosterone and Estradiol Predict Mortality in Elderly Men

Tivesten, Åsa, Vandenput, Liesbeth, Labrie, Fernand, Karlsson, Magnus K., Ljunggren, Östen, Mellström, Dan, Ohlsson, Claes·2009·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2008-2650
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Abstract

Context Age-related reduction of serum testosterone may contribute to the signs and symptoms of aging, but previous studies report conflicting evidence about testosterone levels and male mortality. No large prospective cohort study has determined a possible association between serum estradiol and mortality in men. Objective The main objective was to examine the association between serum testosterone and estradiol and all-cause mortality in elderly men. Design, setting, and participants We used specific gas chromatography-mass spectrometry to analyze serum sex steroids at baseline in older men who participated in the prospective population-based MrOS Sweden cohort (n = 3014; mean age, 75 yr; range, 69-80 yr). Main outcome measure All-cause mortality by serum testosterone and estradiol levels. Results During a mean follow-up period of 4.5 yr, 383 deaths occurred. In multivariate hazards regression models, low levels (within quartile 1 vs. quartiles 2-4) of both testosterone [hazard ratio (HR), 1.65; 95% confidence interval (CI), 1.29-2.12] and estradiol (HR, 1.54; 95% CI, 1.22-1.95) associated with mortality. A model including both hormones showed that both low testosterone (HR, 1.46; 95% CI, 1.11-1.92) and estradiol (HR, 1.33; 95% CI, 1.02-1.73) predicted mortality. Risk of death nearly doubled (HR, 1.96; 95% CI, 1.46-2.62) in subjects with low levels of both testosterone and estradiol compared with subjects within quartiles 2-4 of both hormones. Conclusions Elderly men with l…

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  • Men with low levels of free testosterone and bioavailable testosterone are at a higher risk of mortality.

    “some studies have also demonstrated that men with low levels of free testosterone and bioavailable testosterone are at a higher risk of mortality, 8-10”

    From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [10]

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Authors
Tivesten, A., Vandenput, L., Labrie, F., Karlsson, M. K., Ljunggren, O., Mellström, D., & Ohlsson, C.
Affiliations
  • The Wallenberg Laboratory for Cardiovascular Research (A.T.), Departments of Internal Medicine and Geriatrics, University of Gothenburg, S-413 45 Gothenburg, Sweden
  • University of Gothenburg (SE)
  • Université Laval (CA)
  • Lund University (SE)
  • Department of Medical Sciences (O.L.), University of Uppsala, SE-751 05 Uppsala, Sweden
  • Institute of Medicine, Sahlgrenska Academy, and Center for Bone Research at the Sahlgrenska Academy (L.V., D.M., C.O.), Departments of Internal Medicine and Geriatrics, University of Gothenburg, S-413 45 Gothenburg, Sweden
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2009-07-01
Volume
94
Issue
7
Pages
2482-2488
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2008-2650
OpenAlex
W1983690581
Cited by
243
References
4
Citations by year
2026: 2 · 2025: 6 · 2024: 7 · 2023: 22 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 6 · 2018: 17 · 2017: 12 · 2016: 12 · 2015: 21 · 2014: 31 · 2013: 17 · 2012: 21
FWCI
14.18
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
androgen deficiency, estradiol, all-cause mortality, older men, sex steroids, aging
MeSH terms
Aged, Aged, 80 and over, Cause of Death, Estradiol, Humans, Male, Mortality, Prognosis, Risk Factors, Testosterone, Cohort Studies

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