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Cited by 743Hormonal and reproductive studiesSperm and Testicular FunctionProstate Cancer Treatment and Research

Endogenous Testosterone and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Men: European Prospective Investigation Into Cancer in Norfolk (EPIC-Norfolk) Prospective Population Study

Khaw, Kay-Tee, Dowsett, Mitch, Folkerd, Elizabeth, Bingham, Sheila, Wareham, Nicholas, Luben, Robert, Welch, Ailsa, Day, Nicholas·2007·Circulation
DOI 10.1161/circulationaha.107.719005
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Abstract

Background— The relation between endogenous testosterone concentrations and health in men is controversial. Methods and Results— We examined the prospective relationship between endogenous testosterone concentrations and mortality due to all causes, cardiovascular disease, and cancer in a nested case-control study based on 11 606 men aged 40 to 79 years surveyed in 1993 to 1997 and followed up to 2003. Among those without prevalent cancer or cardiovascular disease, 825 men who subsequently died were compared with a control group of 1489 men still alive, matched for age and date of baseline visit. Endogenous testosterone concentrations at baseline were inversely related to mortality due to all causes (825 deaths), cardiovascular disease (369 deaths), and cancer (304 deaths). Odds ratios (95% confidence intervals) for mortality for increasing quartiles of endogenous testosterone compared with the lowest quartile were 0.75 (0.55 to 1.00), 0.62 (0.45 to 0.84), and 0.59 (0.42 to 0.85), respectively ( P <0.001 for trend after adjustment for age, date of visit, body mass index, systolic blood pressure, blood cholesterol, cigarette smoking, diabetes mellitus, alcohol intake, physical activity, social class, education, dehydroepiandrosterone sulfate, androstanediol glucuronide, and sex hormone binding globulin). An increase of 6 nmol/L serum testosterone (≈1 SD) was associated with a 0.81 (95% confidence interval 0.71 to 0.92, P <0.01) multivariable-adjusted odds ratio for mortality. Inverse relationships were also observed for deaths due to cardiovascular causes and cancer and after the exclusion of deaths that occurred in the first 2 years. Conclusions— In men, endogenous testosterone concentrations are inversely related to mortality due to cardiovascular disease and all causes. Low testosterone may be a predictive marker for those at high risk of cardiovascular disease.

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Crossref · 10.1161/circulationaha.107.719005

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  • Low testosterone levels in men are related to adverse events including increased cardiovascular and all-cause mortality.

    “Likewise, low testosterone levels in men are related to adverse events including increased cardiovascular and all-cause mortality [6–9].”

    From Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial (2019) · cites this paper as [6]

  • With advancing age, testosterone levels drop, and testosterone deficiency is associated with early death, primarily from cardiovascular disease, a decrease in muscle mass and/or strength, and sexual dysfunction.

    “With advancing age, testosterone levels drop, and testosterone deficiency is associated with early death, primarily from cardiovascular disease, a decrease in muscle mass and/or strength, and sexual dysfunction (46).”

    From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [46]

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Authors
Khaw, K.-T., Dowsett, M., Folkerd, E., Bingham, S., Wareham, N., Luben, R., Welch, A., & Day, N.
Affiliations
University of Cambridge (GB)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-12-04
Volume
116
Issue
23
Pages
2694-2701
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.107.719005
OpenAlex
W2136449685
Cited by
743
References
51
Citations by year
2026: 8 · 2025: 17 · 2024: 16 · 2023: 26 · 2022: 28 · 2021: 29 · 2020: 32 · 2019: 26 · 2018: 41 · 2017: 39 · 2016: 39 · 2015: 51 · 2014: 51 · 2013: 56 · 2012: 56
FWCI
40.92
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
  • UEA Digital Repository (University of East Anglia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
Keywords
endogenous testosterone, all-cause mortality, cardiovascular mortality, cancer mortality, men, androgen deficiency, sex hormones, cardiovascular risk prediction, sex hormone-binding globulin, dehydroepiandrosterone sulfate, androstanediol glucuronide
MeSH terms
Adult, Aged, Cardiovascular Diseases, Europe, Humans, Male, Middle Aged, Neoplasms, Predictive Value of Tests, Prospective Studies, Risk Factors, Testosterone

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