Prenatal Determinants of Uterine Volume and Ovarian Reserve in Adolescence
Abstract
Context: Adequate uterine volume and ovarian reserve are essential for reproductive health. Antenatal events such as restricted fetal growth and maternal tobacco smoking are hypothesized to impact on reproductive function in later life, although not studied in a large prospective normal pregnancy population to date. Objective: The objective of the study was to determine the relationship between intrauterine growth, birth weight, and maternal tobacco smoking on uterine volume and ovarian reserve in adolescence. Design and Setting: This was a prospective study in which half the cohort underwent intensive ultrasound monitoring in utero. Participants: Intrauterine growth was measured using ultrasound at 18, 24, 28, and 34/36 wk gestation (n = 115 girls). Maternal smoking data were prospectively collected at 18 and 34/36 wk from the whole cohort. Uterine (n = 229) and early follicular ovarian volume and antral follicle count (n = 225) were measured using transabdominal ultrasound (n = 230). Ovarian reserve was estimated using early follicular phase anti-Mullerian hormone, inhibin B, and FSH (n = 213). Main Outcome Measures: The relationship between maternal tobacco smoking, intrauterine growth trajectories, and markers of ovarian reserve and uterine size in adolescence was measured. Results: Linear regression showed that daughters of mothers who smoked had a significantly smaller uterus compared with nonsmokers (P = 0.019). No significant relationship between maternal tobacco smoking and ovarian volume (P = 0.164) or markers of ovarian reserve (antral follicle count, plasma FSH, anti-Mullerian hormone, and inhibin B) in adolescence was determined. Conclusions: Our findings indicate that maternal smoking, but not variations in fetal growth, may lead to a reduction in uterine volume and does not appear to impact ovarian reserve.
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Between the ages of 2 and 9 years, the size and morphology of the ovaries are relatively stable, with the volume of each ovary being less than 2 cm3; from around 9 years of age onward, the ovaries undergo progressive increases in size.
“Between the ages of 2 and 9 years, the size and morphology of the ovaries are relatively stable, with the volume of each ovary being less than 2 cm 3 ; however, from around 9 years of age onward, the ovaries undergo progressive increases in size. 70”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [70]
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Cites
Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause
Faddy, M. J., Gosden, R. G., Gougeon, A., Richardson, S. J., & Nelson, J. F. (1992) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137570 · Cited by 1,361 · see citing works
Validation of a self-administered instrument to assess stage of adolescent development
Morris, N. M., & Udry, J. R. (1980) · Journal of Youth and Adolescence · doi:10.1007/bf02088471 · Cited by 974 · see citing works
Adams, J., POLSON, D. W., Abdulwahid, N. A., Morris, D. V., Franks, S., Mason, H. D., Tucker, M., Price, J., & Jacobs, H. S. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92552-8 · Cited by 791 · see citing works
Goswami, D., & Conway, G. S. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi012 · Cited by 713 · see citing works
Female reproductive ageing: current knowledge and future trends
Broekmans, F. J., Knauff, E. A. H., te Velde, E. R., Macklon, N. S., & Fauser, B. C. (2007) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2007.01.004 · Cited by 427 · see citing works
Faddy, M. J., & Gosden, R. G. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019422 · Cited by 420 · see citing works
Age at Menarche: Influences of Prenatal and Postnatal Growth
Sloboda, D. M., Hart, R. J., Doherty, D. A., Pennell, C. E., & Hickey, M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1378 · Cited by 282 · see citing works
Self-citationReproductive outcome in patients with diminished ovarian reserve
Levi, A. J., Raynault, M. F., Bergh, P. A., Drews, M. R., Miller, B. T., & Scott, R. T. W. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02017-9 · Cited by 261 · see citing works
Growth hormone: roles in female reproduction
Hull, K., & Harvey, S. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1680001 · Cited by 234 · see citing works
Reduced Uterine and Ovarian Size in Adolescent Girls Born Small for Gestational Age
Ibáñez, L., Potau, N., Enríquez, G., & de Zegher, F. (2000) · Pediatric Research · doi:10.1203/00006450-200005000-00003 · Cited by 199 · see citing works
Radiotherapy at a young age reduces uterine volume of childhood cancer survivors
Larsen, E. C., Schmiegelow, K., Rechnitzer, C., et al. (2003) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.2004.00332.x · Cited by 188 · see citing works
Guerrier, D., Mouchel, T., Pasquier, L., et al. (2006) · Journal of Negative Results in BioMedicine · doi:10.1186/1477-5751-5-1 · Cited by 177 · see citing works
Sonographic size of uterus and ovaries in pre‐ and postmenopausal women
Merz, E., Miric-Tesanic, D., Bahlmann, F., et al. (1996) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1996.07010038.x · Cited by 142 · see citing works
Pubertal maturation of the internal genitalia: an ultrasound evaluation of 166 healthy girls
Holm, K., Laursen, E. M., Brocks, V., & Müller, J. (1995) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1995.06030175.x · Cited by 130 · see citing works
Ibáñez, L. (2003) · Human Reproduction · doi:10.1093/humrep/deg351 · Cited by 128 · see citing works
Ultrasonography of the pelvic organs in prepubertal and postpubertal girls.
Ivarsson, S. A., Nilsson, K., & Persson, P. (1983) · Archives of Disease in Childhood · doi:10.1136/adc.58.5.352 · Cited by 123 · see citing works
Lawson, R. (2003) · Human Reproduction · doi:10.1093/humrep/deg101 · Cited by 121 · see citing works
Fetal growth retardation as a cause of impaired ovarian development
de Bruin, J. P., Dorland, M., Bruinse, H. W., Spliet, W. G. M., Nikkels, P. G. J., & Velde, E. R. T. (1998) · Early Human Development · doi:10.1016/s0378-3782(97)00073-x · Cited by 113 · see citing works
What determines the age at the menopause?
Ginsberg, J. P. (1991) · BMJ · doi:10.1136/bmj.302.6788.1288 · Cited by 112 · see citing works
Oocyte donation in Turner's syndrome: an analysis of the factors affecting the outcome
Khastgir, G., Abdalla, H., Thomas, A. M., Korea, L., Latarche, L., & Studd, J. W. W. (1997) · Human Reproduction · doi:10.1093/humrep/12.2.279 · Cited by 97 · see citing works
High risk pregnancies in hypopituitary women
Overton, C. E., Davis, C. J., West, C. P., et al. (2002) · Human Reproduction · doi:10.1093/humrep/17.6.1464 · Cited by 79 · see citing works
Sonographic imaging of the paediatric female pelvis
Ziereisen, F., Guissard, G., Damry, N., et al. (2005) · European Radiology · doi:10.1007/s00330-005-2648-6 · Cited by 64 · see citing works
Tsilchorozidou, T., & Conway, G. S. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02126.x · Cited by 64 · see citing works
Ovarian reserve evaluation: state of the art
de Carvalho, B. R., Silva, A. C. J. D. S. R. E., Silva, J. C. R. E., dos Reis, R. M., Ferriani, R. A., & de Sá, M. F. S. (2008) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-008-9241-2 · Cited by 63 · see citing works
Morphometry of human ovaries in normal and growth-restricted fetuses
de Bruin, J. P., Nikkels, P. G. J., Bruinse, H. W., van Haaften, M., Looman, C. W. N., & Velde, E. R. T. (2001) · Early Human Development · doi:10.1016/s0378-3782(00)00118-3 · Cited by 51 · see citing works
McDonnell, C. M., Coleman, L. T., & Zacharin, M. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01737.x · Cited by 46 · see citing works
Pelvic Ultrasound Measurements in Normal Girls: Relation to Puberty and Sex Hormone Concentration
Orbak, Z., Sağsöz, N., Alp, E., et al. (1998) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1998.11.4.525 · Cited by 43 · see citing works
Effect of frequent prenatal ultrasound on birthweight: follow up at 1 year of age
MacDonald, W. K., Newnham, J. P., & Gurrin, L. C. (1996) · The Lancet · doi:10.1016/s0140-6736(05)64587-4 · Cited by 27 · see citing works
Self-citationUterine development and endocrine relationships after menarche
Porcu, E., Venturoli, S., Fabbri, R., Orsini, L. F., Sganga, E., Brondelli, L., Paradisi, R., & Flamigni, C. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90259-7 · Cited by 19 · see citing works
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Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline
Teede, H. J., Misso, M. L., Deeks, A. A., Moran, L. J., Stuckey, B. G. A., Wong, J. L. A., Norman, R. J., Costello, M. F., & Groups, O. B. O. T. G. D. (2011) · Medical Journal of Australia · doi:10.5694/mja11.10915 · Cited by 379 · see citing works
Self-citationReproduction in females: The role of the early life environment
Sloboda, D. M., Hickey, M., & Hart, R. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmq048 · Cited by 94 · see citing works
Self-citationBrown, M., Park, A. S., Shayya, R. F., Wolfson, T., Su, H. I., & Chang, R. J. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.23992 · Cited by 54 · see citing works
Radivojevic, U. D., Lazovic, G. B., Kravic-Stevovic, T. K., Puzigaca, Z. D., Canovic, F. M., Nikolic, R. R., & Milicevic, S. M. (2014) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2013.11.007 · Cited by 25 · see citing works
- Authors
- Hart, R., Sloboda, D. M., Doherty, D. A., Norman, R. J., Atkinson, H. C., Newnham, J. P., Dickinson, J. E., & Hickey, M.
- Affiliations
- The University of Western Australia (AU)
- University of Auckland (NZ)
- The University of Adelaide (AU)
- Corresponding author
- Hart, Roger
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2009-12-01
- Volume
- 94
- Issue
- 12
- Pages
- 4931-4937
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1992452077
- Cited by
- 57
- References
- 29
- Citations by year
- 2026: 5 · 2025: 3 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 7
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Raine Medical Research Foundation
- Women and Infants Research Foundation
- Medical Research Council
- National Health and Medical Research Council (403968)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- uterine volume, ovarian reserve, fetal growth, birth weight, antral follicle count, anti-Müllerian hormone, inhibin B, follicle-stimulating hormone, adolescent girls, reproductive health, prenatal factors
- MeSH terms
- Adolescent, Birth Weight, Female, Follicle Stimulating Hormone, Ovarian Follicle, Humans, Inhibins, Ovary, Pregnancy, Prospective Studies, Smoking, Ultrasonography, Uterus, Cohort Studies, Linear Models, Anti-Mullerian Hormone
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