The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Increased Pregnancy Loss Rate in Thyroid Antibody Negative Women with TSH Levels between 2.5 and 5.0 in the First Trimester of Pregnancy
Open accessAbstract
CONTEXT: The definition of what constitutes a normal TSH during pregnancy is in flux. Recent studies suggested that the first trimester upper limit of normal for TSH should be 2.5 mIU/liter. OBJECTIVE: The objective of the study was to evaluate the pregnancy loss and preterm delivery rate in first-trimester thyroid peroxidase antibody-negative women with TSH values between 2.5 and 5.0 mIU/liter. DESIGN: The present study is a component of a recently published large-scale prospective trial that evaluated the impact of levothyroxine treatment on maternal and neonatal complications in thyroid peroxidase-positive women with TSH levels above 2.5 mIU/liter. The present study evaluated 4123 thyroid peroxidase antibody-negative women with TSH levels at or below 5.0 mIU/liter. Women were divided into two groups based on their initial TSH: group A, TSH level below 2.5 mIU/liter, excluding hyperthyroid women defined as an undetectable TSH with an elevated free T(4), and group B, TSH level between 2.5 and 5.0 mIU/liter. SETTING: The study was conducted at two ambulatory clinics of community hospitals in southern Italy. PATIENTS: A total of 4123 women were evaluated. INTERVENTION: There was no intervention. MAIN OUTCOME MEASURES: The incidence of pregnancy loss and preterm delivery in group A as compared with group B was measured. RESULTS: The rate of pregnancy loss was significantly higher in group B as compared with group A (6.1 vs. 3.6% respectively, P = 0.006). There was no difference in the rate of preterm delivery between the two groups. CONCLUSIONS: The increased incidence of pregnancy loss in pregnant women with TSH levels between 2.5 and 5.0 mIU/liter provides strong physiological evidence to support redefining the TSH upper limit of normal in the first trimester to 2.5 mIU/liter.
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Cites
Subclinical hypothyroidism and pregnancy outcomes
Casey, B. M., Dashe, J. S., Wells, C. E., McIntire, D. D., Byrd, W., Leveno, K. J., & Cunningham, F. G. (2005) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000152345.99421.22 · Cited by 903
Subclinical Hyperthyroidism and Pregnancy Outcomes
Casey, B. M., Dashe, J. S., Wells, C. E., McIntire, D. D., Leveno, K. J., & Cunningham, F. G. (2006) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000197991.64246.9a · Cited by 358
Cited by
Stagnaro-Green, A., Abalovich, M., Alexander, E., Azizi, F., Mestman, J., Negro, R., Nixon, A., Pearce, E. N., Soldin, O. P., Sullivan, S., et al. (2011) · Thyroid · doi:10.1089/thy.2011.0087 · Cited by 2,942
Self-citationAlexander, E. K., Pearce, E. N., Brent, G. A., Brown, R. S., Chen, H., Dosiou, C., Grobman, W. A., Laurberg, P., Lazarus, J. H., Mandel, S. J., et al. (2017) · Thyroid® · doi:10.1089/thy.2016.0457 · Cited by 2,731
Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber, K. A. (2012) · Endocrine Practice · doi:10.4158/ep12280.gl · Cited by 1,567
Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber for the American Association, K. A. (2012) · Thyroid · doi:10.1089/thy.2012.0205 · Cited by 1,053
Lazarus, J., Brown, R. S., Daumerie, C., Hubalewska-Dydejczyk, A., Negro, R., & Vaidya, B. (2014) · European Thyroid Journal · doi:10.1159/000362597 · Cited by 742
Self-citationA Review of the Clinical Consequences of Variation in Thyroid Function Within the Reference Range
Taylor, P. N., Razvi, S., Pearce, S. H., & Dayan, C. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1315 · Cited by 274
Treatment with thyroid hormone
Biondi, B., & Wartofsky, L. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1083 · Cited by 259
Li, C., Shan, Z., Mao, J., Wang, W., Xie, X., Zhou, W., Li, C., Xu, B., Bi, L., Meng, T., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1674 · Cited by 249
A national survey on public perceptions of miscarriage
Bardos, J., Hercz, D., Friedenthal, J., Missmer, S. A., & Williams, Z. (2015) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000000859 · Cited by 205
Taylor, P. N., Okosieme, O. E., Dayan, C. M., & Lazarus, J. H. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0651 · Cited by 151
Ethnic differences in maternal thyroid parameters during pregnancy: the Generation R study
Korevaar, T. I. M., Medici, M., de Rijke, Y. B., Visser, W., de Muinck Keizer-Schrama, S. M. P. F., Jaddoe, V. W. V., Hofman, A., Ross, H. A., Visser, W. E., Hooijkaas, H., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2005 · Cited by 150
Zhang, Y., Wang, H., Pan, X., Teng, W., & Shan, Z. (2017) · PLOS ONE · doi:10.1371/journal.pone.0175708 · Cited by 143
Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss
Bernardi, L. A., Cohen, R. N., & Stephenson, M. D. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.07.1975 · Cited by 90
The TSH upper reference limit: where are we at?
Laurberg, P., Andersen, S., Carlé, A., Karmisholt, J., Knudsen, N., & Pedersen, I. B. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.13 · Cited by 86
Maraka, S., Singh Ospina, N. M., Mastorakos, G., & O’Keeffe, D. T. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00090 · Cited by 73
Li, M.-F., Ma, L., Feng, Q.-M., Zhu, Y., Yu, T.-P., Ke, J.-F., Zhang, Z.-H., Liu, Y., & Li, L.-X. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.580380 · Cited by 27
Dhillon‐Smith, R. K., Boelaert, K., Jeve, Y. B., Maheshwari, A., Coomarasamy, A., & Royal College of Obstetricians and Gynaecologists (2022) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17187 · Cited by 16
Milovanović, Z., Filimonović, D., Soldatović, I., & Karadžov Orlić, N. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11133916 · Cited by 10
Metadata
- Authors
- Negro, R., Schwartz, A., Gismondi, R., Tinelli, A., Mangieri, T., & Stagnaro-Green, A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2010-09
- Volume
- 95
- Issue
- 9
- Pages
- E44-E48
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2168576465
- Cited by
- 440
- References
- 2
- FWCI
- 22.02
- Type
- journal article
- Language
- en
- Open access
- green
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