Subclinical Hyperthyroidism and Pregnancy Outcomes
Abstract
OBJECTIVE: Subclinical hyperthyroidism has long-term sequelae that include osteoporosis, cardiovascular morbidity, and progression to overt thyrotoxicosis or thyroid failure. The objective of this study was to evaluate pregnancy outcomes in women with suppressed thyroid-stimulating hormone (TSH) and normal free thyroxine (fT(4)) levels. METHODS: All women who presented to Parkland Hospital for prenatal care between November 1, 2000, and April 14, 2003, underwent thyroid screening by chemiluminescent TSH assay. Women with TSH values at or below the 2.5th percentile for gestational age and whose serum fT(4) levels were 1.75 ng/dL or less were identified to have subclinical hyperthyroidism. Those women screened and delivered of a singleton infant weighing 500 g or more were analyzed. Pregnancy outcomes in women identified with subclinical hyperthyroidism were compared with those in women whose TSH values were between the 5th and 95th percentiles. RESULTS: A total of 25,765 women underwent thyroid screening and were delivered of singleton infants. Of these, 433 (1.7%) were considered to have subclinical hyperthyroidism, which occurred more frequently in African-American and/or parous women. Pregnancies in women with subclinical hyperthyroidism were less likely to be complicated by hypertension (adjusted odds ratio 0.66, 95% confidence interval 0.44-0.98). All other pregnancy complications and perinatal morbidity or mortality were not increased in women with subclinical hyperthyroidism. CONCLUSION: Subclinical hyperthyroidism is not associated with adverse pregnancy outcomes. Our results indicate that identification of subclinical hyperthyroidism and treatment during pregnancy is unwarranted. LEVEL OF EVIDENCE: II-2.
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Gestational hyperthyroidism is not associated with adverse pregnancy outcomes.
“It is not associated with adverse pregnancy outcomes (449).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [449]
Cites
Hollowell, J. G., Staehling, N. W., Flanders, W. D., Hannon, W. H., Gunter, E. W., Spencer, C. A., & Braverman, L. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.2.489 · Cited by 4,279 · see citing works
Haddow, J. E., Palomaki, G. E., Allan, W. C., Williams, J. R., Knight, G. J., Gagnon, J., O'Heir, C. E., Mitchell, M. L., Hermos, R. J., Waisbren, S. E., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908193410801 · Cited by 2,558 · see citing works
Subclinical Thyroid Disease: Scientific Review and Guidelines for Diagnosis and Management
Surks, M. I., Ortiz, E., Daniels, G. H., Sawin, C. T., Col, N. F., Cobin, R. H., Franklyn, J. A., Hershman, J. M., Burman, K. D., Denke, M. A., et al. (2004) · JAMA · doi:10.1001/jama.291.2.228 · Cited by 1,800 · see citing works
Birth weight in relation to morbidity and mortality among newborn infants
McIntire, D. D., Bloom, S. L., Casey, B. M., & Leveno, K. J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904223401603 · Cited by 1,258 · see citing works
Self-citationSubclinical hypothyroidism and pregnancy outcomes
Casey, B. M., Dashe, J. S., Wells, C. E., McIntire, D. D., Byrd, W., Leveno, K. J., & Cunningham, F. G. (2005) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000152345.99421.22 · Cited by 903 · see citing works
Self-citationLow birth weight and preeclampsia in pregnancies complicated by hyperthyroidism
Millar, L. K., Wing, D. A., Leung, A. S., Koonings, P. P., Montoro, M. N., & Mestman, J. H. (1995) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(95)94890-r · Cited by 389 · see citing works
Thyrotoxicosis complicating pregnancy
Davis, L. E., Lucas, M. J., Hankins, G. D. V., Roark, M. L., & Gary Cunningham, F. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90088-4 · Cited by 324 · see citing works
Self-citationHypothyroidism Complicating Pregnancy
Buckshee, K., Kriplani, A., Kapil, A., Bhargava, V. L., & Takkar, D. (2008) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.1992.tb01956.x · Cited by 319 · see citing works
Microchimerism of presumed fetal origin in thyroid specimens from women: a case-control study
Srivatsa, B., Srivatsa, S., Johnson, K. L., Samura, O., Lee, S. L., & Bianchi, D. W. (2001) · The Lancet · doi:10.1016/s0140-6736(01)07099-4 · Cited by 274 · see citing works
Iacobellis, G., Ribaudo, M. C., Zappaterreno, A., Iannucci, C. V., & Leonetti, F. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02247.x · Cited by 253 · see citing works
Nongenomic Actions of Thyroid Hormone on the Heart
Davis, P. J., & Davis, F. B. (2002) · Thyroid · doi:10.1089/105072502760143827 · Cited by 223 · see citing works
Subclinical hyperthyroidism: clinical features and treatment options
Biondi, B., Palmieri, E. A., Klain, M., Schlumberger, M., Filetti, S., & Lombardi, G. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01809 · Cited by 217 · see citing works
Waldorf, K. M. A., & Nelson, J. L. (2004) · JAMA · doi:10.1001/jama.291.9.1127 · Cited by 216 · see citing works
Dashe, J. S., Casey, B. M., Wells, C. E., McIntire, D. D., Byrd, E. W., Leveno, K. J., & Cunningham, F. G. (2005) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000175836.41390.73 · Cited by 203 · see citing works
Self-citationGharib, H., Tuttle, R. M., Baskin, H. J., Fish, L. H., SINGER, P. A., & McDermott, M. T. (2005) · Thyroid · doi:10.1089/thy.2005.15.24 · Cited by 144 · see citing works
Thyrotoxicosis and heart failure that complicate pregnancy
Sheffield, J. S., & Cunningham, F. G. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(03)00944-x · Cited by 127 · see citing works
Self-citationThyroid hormone and the cardiovascular system.
Danzi, S. E., & Klein, I. (2004) · PubMed · Cited by 120 · see citing works
Marqusee, E., Haden, S. T., & Utiger, R. D. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70296-6 · Cited by 74 · see citing works
BENN, P. A., Clive, J. M., & Collins, R. L. (1997) · PubMed · Cited by 59 · see citing works
Observations Concerning the Natural History of Subclinical Hyperthyroidism
Woeber, K. A. (2005) · Thyroid · doi:10.1089/thy.2005.15.687 · Cited by 59 · see citing works
BENN, P. A., Clive, J. M., & Collins, R. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.2.333 · Cited by 54 · see citing works
Thyroid disorders in pregnancy
Lao, T. T.-H. (2005) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/01.gco.0000162179.15360.08 · Cited by 40 · see citing works
Papi, G., Pearce, E. N., Braverman, L. E., Betterle, C., & Roti, E. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.01.004 · Cited by 39 · see citing works
Maternal hemodynamics in pregnancies complicated by hyperthyroidism.
Easterling, T. R., Schmucker, B. C., Carlson, K., Millard, S. P., & Benedetti, T. J. (1991) · PubMed · Cited by 39 · see citing works
The Fetus in Maternal Hyperthyroidism
PERELMAN, A. H., & Clemons, R. D. (1992) · Thyroid · doi:10.1089/thy.1992.2.225 · Cited by 21 · see citing works
Recurrence of mild malformations and dysplasias
Koster, E. (2003) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(03)00530-1 · Cited by 6 · see citing works
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Stagnaro-Green, A., Abalovich, M., Alexander, E., Azizi, F., Mestman, J., Negro, R., Nixon, A., Pearce, E. N., Soldin, O. P., Sullivan, S., et al. (2011) · Thyroid · doi:10.1089/thy.2011.0087 · Cited by 2,942 · see citing works
Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938 · see citing works
Alexander, E. K., Pearce, E. N., Brent, G. A., Brown, R. S., Chen, H., Dosiou, C., Grobman, W. A., Laurberg, P., Lazarus, J. H., Mandel, S. J., et al. (2017) · Thyroid® · doi:10.1089/thy.2016.0457 · Cited by 2,731 · see citing works
DeGroot, L. J., Abalovich, M., Alexander, E. K., Amino, N., Barbour, L. A., Cobin, R. H., Eastman, C. J., Lazarus, J. H., Luton, D., Mandel, S. J., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2803 · Cited by 1,862 · see citing works
The Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418 · see citing works
Thyroid Function and Human Reproductive Health
Krassas, G. E., Poppe, K., & Glinoer, D. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0041 · Cited by 1,223 · see citing works
Bahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., Rivkees, S. A., et al. (2011) · Endocrine Practice · doi:10.4158/ep.17.3.456 · Cited by 1,098 · see citing works
Cooper, D. S., & Biondi, B. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60276-6 · Cited by 1,039 · see citing works
Abalovich, M., Amino, N., Barbour, L. A., Cobin, R. H., DeGroot, L. J., Glinoer, D., Mandel, S. J., & Stagnaro‐Green, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0141 · Cited by 929 · see citing works
The American Thyroid Association and American Association of Clinical Endocrinologists Taskforce on Hyperthyroidism and Other Causes of Thyrotoxicosis, Bahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., et al. (2011) · Thyroid · doi:10.1089/thy.2010.0417 · Cited by 898 · see citing works
Negro, R., Schwartz, A., Gismondi, R., Tinelli, A., Mangieri, T., & Stagnaro‐Green, A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0340 · Cited by 440 · see citing works
Thyroid disease in pregnancy: new insights in diagnosis and clinical management
Korevaar, T. I. M., Medici, M., Visser, T. J., & Peeters, R. P. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.93 · Cited by 441 · see citing works
Davies, T. F., Andersen, S., Latif, R., Nagayama, Y., Barbesino, G., Brito, M., Eckstein, A. K., Stagnaro‐Green, A., & Kahaly, G. J. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0184-y · Cited by 421 · see citing works
Cooper, D. S., & Laurberg, P. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70086-x · Cited by 310 · see citing works
Männistö, T. I., Vääräsmäki, M., Pouta, A. M., Hartikainen, A., Ruokonen, A., Surcel, H., Bloigu, A. H., Järvelin, M., & Suvanto‐Luukkonen, E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1520 · Cited by 303 · see citing works
Karakosta, P., Alegakis, D., Georgiou, V., Roumeliotaki, T., Fthenou, E., Vassilaki, M. E., Boumpas, D., Castanas, E., Kogevinas, M., & Chatzi, L. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2540 · Cited by 299 · see citing works
Polybrominated Diphenyl Ether (PBDE) Flame Retardants and Thyroid Hormone during Pregnancy
Chevrier, J., Harley, K. G., Bradman, A., Gharbi, M., Sjödin, A., & Eskenazi, B. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1001905 · Cited by 297 · see citing works
Su, P., Huang, K., Hao, J., Xu, Y.-Q., Yan, S., Li, T., Xu, Y., & Tao, F. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0274 · Cited by 289 · see citing works
Casey, B. M., & Leveno, K. J. (2006) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000244103.91597.c5 · Cited by 289 · see citing works
Self-citationSubclinical Thyroid Disease and the Incidence of Hypertension in Pregnancy
Wilson, K. L., Casey, B. M., McIntire, D. D., Halvorson, L. M., & Cunningham, F. G. (2012) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e318240de6a · Cited by 268 · see citing works
Self-citationThyroid hormone early adjustment in pregnancy (the THERAPY) trial
Yassa, L., Marqusee, E., Fawcett, R., & Alexander, E. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0013 · Cited by 262 · see citing works
(2020) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003893 · Cited by 220 · see citing works
Assessment and treatment of thyroid disorders in pregnancy and the postpartum period
Lee, S. Y., & Pearce, E. N. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00604-z · Cited by 225 · see citing works
Dong, A. C., & Stagnaro‐Green, A. (2018) · Thyroid · doi:10.1089/thy.2018.0475 · Cited by 203 · see citing works
Stagnaro‐Green, A., Abalovich, M., Alexander, E. K., Azizi, F., Mestman, J. H., Negro, R., Nixon, A., Pearce, E. N., Soldin, O. P., & Wiersinga, W. M. (2011) · Cited by 199 · see citing works
Relationship of Subclinical Thyroid Disease to the Incidence of Gestational Diabetes
Tudela, C. M., Casey, B. M., McIntire, D. D., & Cunningham, F. G. (2012) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e318250aeeb · Cited by 192 · see citing works
Self-citationThyroid Function in Pregnancy: What Is Normal?
Medici, M., Korevaar, T. I. M., Visser, W. E., Visser, T. J., & Peeters, R. P. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.236646 · Cited by 191 · see citing works
Current Concepts and New Trends in the Diagnosis and Management of Recurrent Miscarriage
Alijotas‐Reig, J., & Garrido‐Giménez, C. (2013) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e31828aca19 · Cited by 177 · see citing works
Chen, L., Du, W.-J., Dai, J., Zhang, Q., Si, G.-X., Yang, H., Ye, E., Chen, Q., Yu, L., Zhang, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109364 · Cited by 161 · see citing works
Moreno‐Reyes, R., Glinoer, D., Oyen, H. J. V., & Vandevijvere, S. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2149 · Cited by 160 · see citing works
Toloza, F. J. K., Derakhshan, A., Männistö, T. I., Bliddal, S., Popova, P., Carty, D. M., Chen, L., Taylor, P., Mosso, L. M., Oken, E., et al. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00007-9 · Cited by 164 · see citing works
Thyroid disorders in pregnancy
Stagnaro‐Green, A., & Pearce, E. N. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.171 · Cited by 154 · see citing works
Dosiou, C., Barnes, J. I., Schwartz, A., Negro, R., Crapo, L. M., & Stagnaro‐Green, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2884 · Cited by 142 · see citing works
Abdelouahab, N., Langlois, M., Lavoie, L., Corbin, F., Pasquier, J., & Takser, L. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kwt141 · Cited by 142 · see citing works
Indications for Outpatient Antenatal Fetal Surveillance
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Effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy.
Wang, S., Teng, W., Li, J. X., Wang, W. W., & Shan, Z. (2012) · PubMed · doi:10.3275/7772 · Cited by 141 · see citing works
TSH Levels and Risk of Miscarriage in Women on Long-Term Levothyroxine: A Community-Based Study
Taylor, P. N., Minassian, C., Rehman, A. U., Iqbal, A., Draman, M. S., Hamilton, W. T., Dunlop, D. C., Robinson, A., Vaidya, B., Lazarus, J. H., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1954 · Cited by 143 · see citing works
Overt Hyperthyroidism and Hypothyroidism During Pregnancy
Stagnaro‐Green, A. (2011) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3182272f32 · Cited by 129 · see citing works
Maternal Thyroid Disease and Preterm Delivery
Stagnaro‐Green, A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1288 · Cited by 126 · see citing works
Therapy Insight: management of Graves' disease during pregnancy
Chan, G. W., & Mandel, S. J. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0508 · Cited by 122 · see citing works
Physiological and anatomical changes of pregnancy: Implications for anaesthesia
Bhatia, P. K., & Chhabra, S. (2018) · Indian Journal of Anaesthesia · doi:10.4103/ija.ija_458_18 · Cited by 120 · see citing works
Serum TSH determinations in pregnancy: how, when and why?
Glinoer, D., & Spencer, C. A. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.91 · Cited by 119 · see citing works
Chan, S., & Boelaert, K. (2014) · Clinical Endocrinology · doi:10.1111/cen.12605 · Cited by 117 · see citing works
Thyroid hormone dysfunction during pregnancy: A review
Alemu, A., Terefe, B., Abebe, M., & Biadgo, B. (2016) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.29252/ijrm.14.11.677 · Cited by 116 · see citing works
The cost-effectiveness of universal screening in pregnancy for subclinical hypothyroidism
Thung, S. F., Funai, E. F., & Grobman, W. A. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.10.035 · Cited by 115 · see citing works
Laurberg, P., & Andersen, S. L. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0135 · Cited by 115 · see citing works
Thyroid dysfunction and pregnancy outcomes.
Nazarpour, S., Tehrani, F. R., Simbar, M., & Azizi, F. (2015) · PubMed Central · Cited by 115 · see citing works
León, G., Murcia, M., Rebagliato, M., Álvarez‐Pedrerol, M., Castilla, A. M., Basterrechea, M., Íñiguez, C., Fernández‐Somoano, A., Blarduni, E., Foradada, C. M., et al. (2015) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12172 · Cited by 112 · see citing works
Marx, H., Amin, P., & Lazarus, J. H. (2008) · BMJ · doi:10.1136/bmj.39462.709005.ae · Cited by 110 · see citing works
Screening pregnant women for autoimmune thyroid disease: a cost-effectiveness analysis.
Dosiou, C., Sanders, G. D., Araki, S. S., & Crapo, L. M. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0882 · Cited by 102 · see citing works
Johns, L. E., Ferguson, K. K., McElrath, T. F., Mukherjee, B., & Meeker, J. D. (2016) · Environmental Health Perspectives · doi:10.1289/ehp170 · Cited by 99 · see citing works
Springer, D., Zima, T., & Limanova, Z. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-0890 · Cited by 98 · see citing works
Gilbert, R. M., Hadlow, N. C., Walsh, J. P., Fletcher, S. J., Brown, S. J., Stuckey, B. G. A., & Lim, E. M. (2008) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2008.tb02015.x · Cited by 98 · see citing works
Managing thyroid disease in general practice
Walsh, J. P. (2016) · The Medical Journal of Australia · doi:10.5694/mja16.00545 · Cited by 96 · see citing works
Spontaneous Abortion, Stillbirth and Hyperthyroidism: A Danish Population-Based Study
Andersen, S. L., Olsen, J., Wu, C. S., & Laurberg, P. (2014) · European Thyroid Journal · doi:10.1159/000365101 · Cited by 91 · see citing works
Graves’ hyperthyroidism in pregnancy: a clinical review
Nguyen, C. T., Sasso, E. B., Barton, L., & Mestman, J. H. (2018) · Clinical Diabetes and Endocrinology · doi:10.1186/s40842-018-0054-7 · Cited by 94 · see citing works
Pregnant Women on Thyroxine Substitution Are Often Dysregulated in Early Pregnancy
Hallengren, B., Lantz, M., Andreasson, B., & Grennert, L. (2009) · Thyroid · doi:10.1089/thy.2008.0206 · Cited by 88 · see citing works
Negro, R., Schwartz, A., & Stagnaro‐Green, A. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1803 · Cited by 84 · see citing works
Thyroid function and thyroid disorders during pregnancy: a review and care pathway
Delitala, A., Capobianco, G., Cherchi, P. L., Dessole, S., & Delitala, G. (2018) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-018-5018-8 · Cited by 74 · see citing works
Diagnosis and Management of Thyroid Disease in Pregnancy
Fitzpatrick, D. L., & Russell, M. (2010) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2010.02.007 · Cited by 73 · see citing works
Hyperthyroidism in the pregnant woman: Maternal and fetal aspects
Moleti, M., Mauro, M. D., Sturniolo, G., Russo, M., & Vermiglio, F. (2019) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2019.100190 · Cited by 74 · see citing works
Subclinical Hypothyroidism in Pregnancy: Intellectual Development of Offspring
Behrooz, H. G., Tohidi, M., Mehrabi, Y., Behrooz, E. G., Tehranidoost, M., & Azizi, F. (2011) · Thyroid · doi:10.1089/thy.2011.0053 · Cited by 73 · see citing works
Chevrier, J., Harley, K. G., Kogut, K. R., Holland, N., Johnson, C. B., & Eskenazi, B. (2011) · Journal of Thyroid Research · doi:10.4061/2011/426427 · Cited by 68 · see citing works
Thyroid function and pregnancy: Before, during and beyond
Kennedy, R. L., Malabu, U. H., Jarrod, G., Nigam, P., Kannan, K., & Rane, A. (2010) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443615.2010.517331 · Cited by 66 · see citing works
Zhao, T., Xiaowen, Z., Chen, B., Liu, A., Yingying, Z., Teng, W., & Zhongyan, S. (2016) · Medicine · doi:10.1097/md.0000000000003677 · Cited by 66 · see citing works
Thyrotropin Isoforms: Implications for Thyrotropin Analysis and Clinical Practice
Estrada, J. M., Soldin, D., Buckey, T. M., Burman, K. D., & Soldin, O. P. (2014) · Thyroid® · doi:10.1089/thy.2013.0119 · Cited by 64 · see citing works
Rajput, R., Goel, V., Nanda, S., Rajput, M., & Seth, S. (2015) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.152791 · Cited by 60 · see citing works
Preconception management of thyroid dysfunction
Okosieme, O. E., Khan, I. N., & Taylor, P. N. (2018) · Clinical Endocrinology · doi:10.1111/cen.13731 · Cited by 59 · see citing works
Is Age a Risk Factor for Hypothyroidism in Pregnancy? An Analysis of 5223 Pregnant Women
Potluková, E., Potluka, O., Jiskra, J., Limanova, Z., Telička, Z., Bartáková, J., & Springer, D. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3275 · Cited by 59 · see citing works
Diagnosing Thyroid Dysfunction in Pregnant Women: Is Case Finding Enough?
Brent, G. A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2461 · Cited by 58 · see citing works
Benign thyroid disease in pregnancy: A state of the art review
Tingi, E., Syed, A. A., Kyriacou, A., Mastorakos, G. P., & Kyriacou, A. (2016) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2016.11.001 · Cited by 59 · see citing works
Screening for Thyroid Dysfunction in Pregnancy: Is It Worthwhile?
Lazarus, J. H. (2011) · Journal of Thyroid Research · doi:10.4061/2011/397012 · Cited by 57 · see citing works
Approach to the Pregnant Patient with Thyroid Cancer
Mazzaferri, E. L. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1624 · Cited by 56 · see citing works
Thyroid disorders during pregnancy and postpartum
Pearce, E. N. (2015) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2015.04.007 · Cited by 55 · see citing works
Czerska, M., Zieliński, M., Kamińska, J., & Ligocka, D. (2013) · International Journal of Occupational Medicine and Environmental Health · doi:10.2478/s13382-013-0138-7 · Cited by 55 · see citing works
Thyroid hormone signaling and consequences for cardiac development
Chattergoon, N. N. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0704 · Cited by 55 · see citing works
Maternal thyroid disease and its effects on the fetus and perinatal outcomes
Huget‐Penner, S., & Feig, D. S. (2020) · Prenatal Diagnosis · doi:10.1002/pd.5684 · Cited by 54 · see citing works
Sgarbi, J. A., Teixeira, P. D. F. D. S., Maciel, L. M. Z., Mazeto, G. M. F. D. S., Vaisman, M., Montenegro, R. M., & Ward, L. S. (2013) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302013000300003 · Cited by 56 · see citing works
Kobaly, K. N., & Mandel, S. J. (2019) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2019.05.002 · Cited by 53 · see citing works
Arbib, N., Hadar, E., Sneh‐Arbib, O., Chen, R., Wiznitzer, A., & Gabbay‐Benziv, R. (2016) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2016.1242123 · Cited by 52 · see citing works
Persistency of Thyroid Dysfunction from Early to Late Pregnancy
Fan, J., Zhang, Y., Zhang, C., Barjaktarovic, M., Yang, X., Peeters, R. P., Huang, H., & Korevaar, T. I. M. (2019) · Thyroid · doi:10.1089/thy.2019.0115 · Cited by 50 · see citing works
Obstetric Management of Thyroid Disease
Rashid, M., & Rashid, M. H. (2007) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000281558.59184.b5 · Cited by 51 · see citing works
Carlé, A., Andersen, S. L., Boelaert, K., & Laurberg, P. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0276 · Cited by 48 · see citing works
Mazzaferri, E. L. (2007) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)70113-6 · Cited by 48 · see citing works
Ferrater, J. C. G., Hernández, J. J. C., Corral, B. P., Blanco, A. C., Alonso, N., Pérez, A., Morales, T. L., & Henzi, F. T. (2009) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(09)70556-x · Cited by 47 · see citing works
Management of overt hypothyroidism during pregnancy
Li, S. W., & Chan, S. (2020) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2020.101439 · Cited by 46 · see citing works
Carney, L. A., Quinlan, J. D., & West, J. M. (1993) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(93)90283-3 · Cited by 46 · see citing works
Subclinical Hyperthyroidism: A Review of the Clinical Literature
Tsai, K., & Leung, A. M. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.02.002 · Cited by 45 · see citing works
Universal screening for thyroid disease during pregnancy should be performed
Stagnaro‐Green, A., Dong, A. C., & Stephenson, M. D. (2019) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2019.101320 · Cited by 44 · see citing works
Yang, Y., Guo, T., Fu, J., Kuang, J., Wang, Y., Zhang, Y. P., Zhang, H., He, Y., Peng, Z., Wang, Q., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.5723 · Cited by 43 · see citing works
Springer, D., Bartos, V., & Zima, T. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2013.860617 · Cited by 43 · see citing works
Management of Subclinical Hyperthyroidism
Palacios, S. S., Corrales, E. P., & Galofré, J. C. (2012) · Intern J Endocrinol Metab · doi:10.5812/ijem.3447 · Cited by 43 · see citing works
Clinical analysis of 65 cases of hyperemesis gravidarum with gestational transient thyrotoxicosis
Sun, S., Qiu, X., & Zhou, J. (2014) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12372 · Cited by 41 · see citing works
Identifying and treating subclinical thyroid dysfunction in pregnancy: emerging controversies
Velasco, I., & Taylor, P. N. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0598 · Cited by 41 · see citing works
Thyroid Disease in Pregnancy: A Descriptive Review of Guidelines
Tsakiridis, I. G., Giouleka, S., Kourtis, A., Mamopoulos, A. M., Athanasiadis, A. P., & Dagklis, T. (2022) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000960 · Cited by 42 · see citing works
ENDOCRINOLOGY IN PREGNANCY: Pregnancy and the incidence, diagnosing and therapy of Graves’ disease
Laurberg, P., & Andersen, S. L. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0410 · Cited by 42 · see citing works
Effects of thyroid diseases on pregnancy outcomes
Zhou, M., Wang, M., Li, J., Luo, X., & Lei, M. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7739 · Cited by 40 · see citing works
Maternal thyroid function during gestation is related to breech presentation at term
Kuppens, S. M., Kooistra, L., Wijnen, H. A. A., Crawford, S., Vader, H. L., Hasaart, T. H. M., Oei, S. G., & Pop, V. J. M. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03729.x · Cited by 40 · see citing works
Korevaar, T. I. M., Leung, A. M., Alexander, E. K., Bliddal, S., Boelaert, K., Brenta, G., Chou, R., Dhillon‐Smith, R. K., Dosiou, C., Eaton, J. L., et al. (2026) · Thyroid · doi:10.1177/10507256261445624 · Cited by 45 · see citing works
Zhang, Y., Li, Y., Shan, Z., Xu, Y., Li, C., Xie, X., Li, Y., Wang, W., Mao, J., & Teng, W. (2019) · Journal of Women s Health · doi:10.1089/jwh.2018.7180 · Cited by 39 · see citing works
- Authors
- Casey, B. M., Dashe, J. S., Wells, C. E., McIntire, D. D., Leveno, K. J., & Cunningham, F. G.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Obstetrics & Gynecology
- Published
- 2006-02
- Volume
- 107
- Issue
- 2, Part 1
- Pages
- 337-341
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W1983381211
- Cited by
- 358
- References
- 26
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 7 · 2023: 15 · 2022: 23 · 2021: 20 · 2020: 13 · 2019: 22 · 2018: 18 · 2017: 13 · 2016: 28 · 2015: 20 · 2014: 18 · 2013: 24 · 2012: 22
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- subclinical hyperthyroidism, pregnancy outcomes, thyroid-stimulating hormone, free thyroxine, gestational age, hypertension in pregnancy, perinatal morbidity, African American women, parous women
- MeSH terms
- Adult, Female, Humans, Hyperthyroidism, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Thyrotropin, Prevalence
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