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Cited by 383Ovarian function and disordersSexual Differentiation and DisordersReproductive Biology and Fertility

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Serum levels of anti-mullerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients

Hagen, Casper P., Aksglaede, Lise, Sørensen, Kaspar, Main, Katharina M., Boas, Malene, Cleemann, Line, Holm, Kirsten, Gravholt, Claus H., Andersson, Anna-Maria, Pedersen, Anette T., Petersen, Jørgen Holm, Linneberg, Allan, Kjaergaard, Susanne, Juul, Anders·2010·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2010-0930
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Abstract

CONTEXT: In adult women, anti-Müllerian hormone (AMH) is related to the ovarian follicle pool. Little is known about AMH in girls. OBJECTIVE: The objective of the study was to provide a reference range for AMH in girls and adolescents and to evaluate AMH as a marker of ovarian function. SETTING: The study was conducted at a tertiary referral center for pediatric endocrinology. MAIN OUTCOME MEASURES: We measured AMH in 926 healthy females (longitudinal values during infancy) as well as in 172 Turner syndrome (TS) patients according to age, karyotype (A: 45,X; B: miscellaneous karyotypes; C: 45,X/46,XX), and ovarian function (1: absent puberty; 2: cessation of ovarian function; 3: ongoing ovarian function). RESULTS: AMH was undetectable in 54% (38 of 71) of cord blood samples (<2; <2-15 pmol/liter) (median; 2.5th to 97.5th percentile) and increased in all (37 of 37) infants from birth to 3 months (15; 4.5-29.5 pmol/liter). From 8 to 25 yr, AMH levels were stable (19.9; 4.7-60.1 pmol/liter), with the lower level of the reference range clearly above the detection limit. AMH levels were associated with TS-karyotype groups (median A vs. B: <2 vs. 3 pmol/liter, P = 0.044; B vs. C: 3 vs. 16 pmol/liter, P < 0.001) as well as with ovarian function (absent puberty vs. cessation of ovarian function: <2 vs. 6 pmol/liter, P = 0.004; cessation of ovarian function vs. ongoing ovarian function: 6 vs. 14 pmol/liter, P = 0.001). As a screening test of premature ovarian failure in TS, the sensitivity and specificity of AMH less than 8 pmol/liter was 96 and 86%, respectively. CONCLUSION: AMH seems to be a promising marker of ovarian function in healthy girls and TS patients.

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Metadata

Authors
Hagen, C. P., Aksglaede, L., Sørensen, K., Main, K. M., Boas, M., Cleemann, L., Holm, K., Gravholt, C. H., Andersson, A.-M., Pedersen, A. T., Petersen, J. H., Linneberg, A., Kjaergaard, S., & Juul, A.
Affiliations
  • Copenhagen University Hospital (DK)
  • Nordsjællands Hospital (DK)
  • Aarhus University Hospital (DK)
  • Glostrup Hospital (DK)
Corresponding author
Hagen, Casper P.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2010-11
Volume
95
Issue
11
Pages
5003-5010
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2010-0930
OpenAlex
W2117364932
Cited by
383
References
35
Citations by year
2026: 5 · 2025: 16 · 2024: 41 · 2023: 17 · 2022: 24 · 2021: 23 · 2020: 26 · 2019: 25 · 2018: 26 · 2017: 19 · 2016: 24 · 2015: 16 · 2014: 26 · 2013: 38 · 2012: 36
FWCI
35.67
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords
anti-Müllerian hormone, Turner syndrome, ovarian function, ovarian reserve, reference values, umbilical cord blood, premature ovarian failure, karyotype, girls and adolescents, longitudinal development, sensitivity and specificity, healthy women, 45,X/46,XX mosaicism, 45,X karyotype, 46,XX karyotype
MeSH terms
Adolescent, Adult, Age Factors, Aged, Child, Female, Humans, Infant, Infant, Newborn, Inhibins, Middle Aged, Ovary, Reference Values, ROC Curve, Turner Syndrome, Biomarkers, Statistics, Nonparametric, Anti-Mullerian Hormone

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