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Altered Autophagy in Human Adipose Tissues in Obesity

Kovsan, Julia, Blüher, Matthias, Tarnovscki, Tanya, Klöting, Nora, Kirshtein, Boris, Madar, Liron, Shai, Iris, Golan, Rachel, Harman-Boehm, Ilana, Schön, Michael R., Greenberg, Andrew S., Elazar, Zvulun, Bashan, Nava, Rudich, Assaf·2011·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2010-1681
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Abstract

Context Autophagy is a housekeeping mechanism, involved in metabolic regulation and stress response, shown recently to regulate lipid droplets biogenesis/breakdown and adipose tissue phenotype. Objective We hypothesized that in human obesity autophagy may be altered in adipose tissue in a fat depot and distribution-dependent manner. Setting and patients Paired omental (Om) and subcutaneous (Sc) adipose tissue samples were used from obese and nonobese (n = 65, cohort 1); lean, Sc-obese and intraabdominally obese (n = 196, cohort 2); severely obese persons without diabetes or obesity-associated morbidity, matched for being insulin sensitive or resistant (n = 60, cohort 3). Results Protein and mRNA levels of the autophagy genes Atg5, LC3A, and LC3B were increased in Om compared with Sc, more pronounced among obese persons, particularly with intraabdominal fat accumulation. Both adipocytes and stromal-vascular cells contribute to the expression of autophagy genes. An increased number of autophagosomes and elevated autophagic flux assessed in fat explants incubated with lysosomal inhibitors were observed in obesity, particularly in Om. The degree of visceral adiposity and adipocyte hypertrophy accounted for approximately 50% of the variance in omental Atg5 mRNA levels by multivariate regression analysis, whereas age, sex, measures of insulin sensitivity, inflammation, and adipose tissue stress were excluded from the model. Moreover, in cohort 3, the autophagy marker genes were inc…

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Research works printed but not linked: 19

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  8. Blüher, 2009, Activated Ask1-MKK4–p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body Insulin sensitivity., J Clin Endocrinol Metab, 94, 2507, 10.1210/jc.2009-0002 · DOI
  9. Harman-Boehm, 2007, Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity., J Clin Endocrinol Metab, 92, 2240, 10.1210/jc.2006-1811 · DOI · Paper page
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Metadata

Authors
Kovsan, J., Blüher, M., Tarnovscki, T., Klöting, N., Kirshtein, B., Madar, L., Shai, I., Golan, R., Harman-Boehm, I., Schön, M. R., Greenberg, A. S., Elazar, Z., Bashan, N., & Rudich, A.
Affiliations
  • Departments of Clinical Biochemistry (J.K., T.T., L.M., N.B., A.R.) Ben-Gurion University of the Negev, Beer-Sheva 84103, Israel;
  • Department of Medicine (M.B., N.K.), University of Leipzig, D-04103 Leipzeig, Germany;
  • Department of Surgery A (B.K.) Soroka Medical Center, Beer-Sheva 84101, Israel;
  • Departments of Epidemiology (I.S., R.G.) Ben-Gurion University of the Negev, Beer-Sheva 84103, Israel;
  • Diabetes Unit (I.H.-B.), Soroka Medical Center, Beer-Sheva 84101, Israel;
  • Städtisches Klinikum Karlsruhe (M.R.S.), Clinic of Visceral Surgery, D-76133 Karlsruhe, Germany;
  • Jean Mayer Human Nutrition Research Center-U.S. Department of Agriculture Human Nutrition Research Center on Aging (A.S.G.), Tufts Univeristy, Boston, Massachusetts 02111;
  • Department of Biological Chemistry (Z.E.), The Weizmann Institute of Science, Rehovot 76100, Israel
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2011-02-01
Volume
96
Issue
2
Pages
E268-E277
ISSN
  • 0021-972X
  • 1945-7197
DOI
10.1210/jc.2010-1681
Cited by
301
References
6
Language
en

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