Macrophage Infiltration into Omental Versus Subcutaneous Fat across Different Populations: Effect of Regional Adiposity and the Comorbidities of Obesity
Abstract
CONTEXT: Macrophage infiltration into adipose tissue has been demonstrated to accompany obesity, with a potential preferential infiltration into intraabdominal vs. sc fat. OBJECTIVE: Our objective was to determine whether this occurs across different populations with a range of body mass indexes and to assess the relationship with regional adiposity and comorbidity of obesity. SETTING AND PATIENTS: In two independent cohorts, we used paired omental (OM) and sc fat biopsies from lean controls or predominantly sc or intraabdominally obese persons with minimal comorbidity (n = 60, cohort 1), or from severely obese women with a significant rate of comorbidity (n = 29, cohort 2). RESULTS: Elevated macrophage infiltration into OM vs. sc fat was observable in lean subjects and exaggerated by obesity, particularly if predominantly intraabdominal. This was paralleled by increased monocyte chemoattractant protein-1 (MCP1) and colony-stimulating factor-1 (CSF1) mRNA levels. Level of CSF1 and MCP1 mRNA correlated with the number of OM macrophages (r = 0.521, P < 0.0001 and r = 0.258, P < 0.051, respectively). In severely obese women (mean body mass index = 43.0 +/- 1.1 kg/m(2)), higher protein expression of both MCP1 and CSF1 was detected in OM vs. sc fat. Number of OM macrophages, but not of sc macrophages, correlated with waist circumference (r = 0.636, P = 0.001 vs. r = 0.170, P = 0.427) and with the number of metabolic syndrome parameters (r = 0.385, P = 0.065 vs. r = -0.158, P = 0.472, respectively). Preferential macrophage infiltration into OM fat was mainly observed in a subgroup in whom obesity was associated with impaired glucose homeostasis. CONCLUSIONS: Preferential macrophage infiltration into OM fat is a general phenomenon exaggerated by central obesity, potentially linking central adiposity with increased risk of diabetes and coronary heart disease.
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From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [684]
Visceral adipose tissue macrophage counts are higher in insulin-resistant obese patients than in lean or insulin-sensitive obese patients.
“Several detailed studies have also reported a higher macrophage count in visceral AT of insulin-resistant obese patients compared with lean or insulin-sensitive obese counterparts, an effect that was significantly mitigated following bariatric surgery (10,(114)(115)(116).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [115]
Bariatric surgery significantly reduces the elevated visceral adipose tissue macrophage count in insulin-resistant obese patients.
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From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [115]
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Self-citation
- Authors
- Harman-Boehm, I., Blüher, M., Redel, H., Sion-Vardy, N., Ovadia, S., Avinoach, E., Shai, I., Klöting, N., Stumvoll, M., Bashan, N., & Rudich, A.
- Affiliations
- Diabetes Unit and Internal Medicine C (I.H.-B.), Soroka Medical Center, Beer-Sheva 84101, Israel
- Medical Department III (M.B., N.K., M.S.), University of Leipzig, 04109 Leipzig, Germany
- Soroka Medical Center (IL)
- Pathology Institute (H.R., N.S.-V.), Soroka Medical Center, Beer-Sheva 84101, Israel
- Ben-Gurion University of the Negev (IL)
- Corresponding author
- Rudich, Assaf
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2007-06-01
- Volume
- 92
- Issue
- 6
- Pages
- 2240-2247
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1976844022
- Cited by
- 574
- References
- 21
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 20 · 2023: 25 · 2022: 29 · 2021: 23 · 2020: 37 · 2019: 38 · 2018: 24 · 2017: 36 · 2016: 30 · 2015: 33 · 2014: 38 · 2013: 37 · 2012: 32
- FWCI
- 25.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- macrophage infiltration, omental fat, subcutaneous adipose tissue, regional adiposity, abdominal obesity, intra-abdominal fat, obesity-related comorbidities, metabolic syndrome, MCP-1, colony-stimulating factor 1, adipose tissue inflammation, impaired glucose homeostasis
- MeSH terms
- Adult, Aged, Biopsy, Cell Movement, Female, Humans, Macrophages, Male, Middle Aged, Obesity, Omentum, RNA, Messenger, Cohort Studies, Comorbidity, Body Mass Index, Macrophage Colony-Stimulating Factor, Chemokine CCL2, Subcutaneous Fat, Abdominal
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