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Independent and Combined Effects of Calcium-Vitamin D3 and Exercise on Bone Structure and Strength in Older Men: An 18-Month Factorial Design Randomized Controlled Trial

Kukuljan, Sonja, Nowson, Caryl A., Sanders, Kerrie M., Nicholson, Geoff C., Seibel, Markus J., Salmon, Jo, Daly, Robin M.·2011·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2010-2284
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Abstract

Context: Exercise and calcium-vitamin D are independently recognized as important strategies to prevent osteoporosis, but their combined effects on bone strength and its determinants remain uncertain. Objective: To assess whether calcium-vitamin D3 fortified milk could enhance the effects of exercise on bone strength, structure, and mineral density in middle-aged and older men. Design, Setting, Participants: An 18-month factorial design randomized controlled trial in which 180 men aged 50–79 years were randomized to the following: exercise + fortified milk; exercise; fortified milk; or controls. Exercise consisted of progressive resistance training with weight-bearing impact activities performed 3 d/week. Men assigned to fortified milk consumed 400 ml/d of 1% fat milk containing 1000 mg/d calcium and 800 IU/d vitamin D3. Main Outcome Measures: Changes in bone mineral density (BMD), bone structure, and strength at the lumbar spine (LS), proximal femur, mid-femur, and mid-tibia measured by dual energy x-ray absorptiometry and/or quantitative computed tomography. Results: There were no exercise-by-fortified milk interactions at any skeletal site. Main effect analysis showed that exercise led to a 2.1% (95% confidence interval, 0.5–3.6) net gain in femoral neck section modulus, which was associated with an approximately 1.9% gain in areal BMD and cross-sectional area. Exercise also improved LS trabecular BMD [net gain 2.2% (95% confidence interval, 0.2–4.1)], but had no effect on mid-femur or mid-tibia BMD, structure, or strength. There were no main effects of the fortified milk at any skeletal site. Conclusion: A community-based multi-component exercise program successfully improved LS and femoral neck BMD and strength in healthy older men, but providing additional calcium-vitamin D3 to these replete men did not enhance the osteogenic response.

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Research works printed but not linked: 25

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Metadata

Authors
Kukuljan, S., Nowson, C. A., Sanders, K. M., Nicholson, G. C., Seibel, M. J., Salmon, J., & Daly, R. M.
Affiliations
  • School of Exercise and Nutrition Sciences (S.K., C.A.N., J.S., R.M.D.), Deakin University, Victoria 3125, Australia;
  • Department of Clinical and Biomedical Sciences: Barwon Health (K.M.S., G.C.N.), University of Melbourne, Geelong Victoria 3220, Australia;
  • Bone Research Program (M.J.S.), ANZAC Research Institute, University of Sydney, New South Wales 2006, Australia;
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2011-04-01
Volume
96
Issue
4
Pages
955-963
ISSN
  • 0021-972X
  • 1945-7197
DOI
10.1210/jc.2010-2284
Cited by
116
References
3
Language
en

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