The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Cancer Risks in Patients Treated With Growth Hormone in Childhood: The SAGhE European Cohort Study
Open accessAbstract
Context: Growth hormone (GH) is prescribed for an increasing range of indications, but there has been concern that it might raise cancer risk. Published data are limited. Objective: To examine cancer risks in relation to GH treatment. Design: Cohort study. Setting: Population-based. Patients: Cohort of 23,984 patients treated with recombinant human GH (r-hGH) in eight European countries since this treatment was first used in 1984. Cancer expectations from country-specific national population statistics. Main Outcome Measures: Cancer incidence and cancer mortality. Results: Incidence and mortality risks in the cohort were raised for several cancer sites, largely consequent on second primary malignancies in patients given r-hGH after cancer treatment. There was no clear raised risk in patients with growth failure without other major disease. Only for bone and bladder cancers was incidence significantly raised in GH-treated patients without previous cancer. Cancer risk was unrelated to duration or cumulative dose of r-hGH treatment, but for patients treated after previous cancer, cancer mortality risk increased significantly with increasing daily r-hGH dose (P trend < 0.001). Hodgkin lymphoma (HL) incidence increased significantly with longer follow-up (P trend = 0.001 for patients overall and 0.002 for patients without previous cancer). Conclusions: Our results do not generally support a carcinogenic effect of r-hGH, but the unexplained trend in cancer mortality risk in relation to GH dose in patients with previous cancer, and the indication of possible effects on bone cancer, bladder cancer, and HL risks, need further investigation.
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“data from GH registries provide no evidence of an increase in risk of neoplasia with treatment.173,208,222-224”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [223]
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Cites
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
Breslow, N. E., & Day, N. E. (1980) · PubMed · Cited by 4,895
Mortality and Cancer Incidence in Acromegaly: A Retrospective Cohort Study 1
Orme, S. M., McNally, R., Cartwright, R. A., & Belchetz, P. E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.8.5007 · Cited by 805
Growth Promotion Ethics and the Challenge to Resist Cosmetic Endocrinology
Allen, D. B. (2017) · Hormone Research in Paediatrics · doi:10.1159/000458526 · Cited by 554
Growth hormone, the insulin-like growth factor axis, insulin and cancer risk
Clayton, P., Banerjee, I., Murray, P. G., & Renehan, A. G. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.171 · Cited by 362 · cited 2×
“For the three cancer sites for which there is most published support for an association with IGF-1 levels— colorectum, breast, and prostate (2)—the evidence from our cohort and previously (9, 10, 18, 19) is too sparse to reach a conclusion on relations to GH treatment, reflecting the rarity of these cancers at childho…”
BackgroundSklar, C. A., Mertens, A. C., Mitby, P. A., Occhiogrosso, G., Qin, J., Heller, G., Yasui, Y., & Robison, L. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8606 · Cited by 307
Long-term safety of recombinant human growth hormone in children
Bell, J., Parker, K. L., Swinford, R. D., Hoffman, A. R., Maneatis, T., & Lippe, B. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0178 · Cited by 301 · cited 2×
“, neurofibromatosis) that lead to GH therapy are themselves strong predisposing factors for cancer, we followed previous practice (11, 12, 16) in excluding individuals with such conditions (listed in Supplemental Data) from analysis.”
BackgroundMethodCarel, J., Écosse, E., Landier, F., Meguellati-Hakkas, D., Kaguelidou, F., Rey, G., & Coste, J. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1995 · Cited by 295
Swerdlow, A. J., Higgins, C. D., Adlard, P., & Preece, M. A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09519-3 · Cited by 289
Growth Hormone Treatment and Risk of Second Neoplasms in the Childhood Cancer Survivor
Ergun-Longmire, B., Mertens, A. C., Mitby, P. A., Qin, J., Heller, G., Shi, W., Yasui, Y., Robison, L. L., & Sklar, C. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0656 · Cited by 272 · cited 4×
“Potential effects on leukemia (5, 6) and other malignancy (1) risks have been suggested, and second primary malignancy risk has been shown raised in patients receiving GH after childhood cancer (7, 8).”
BackgroundInfluentialSvensson, J., Bengtsson, B. ‐., Rosén, T., Odén, A., & Johannsson, G. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031601 · Cited by 236
Flagged first, then by citations
Research works printed but not linked: 1
- 2005, Second cancers
Cited by
Sorted by citations
Items 101–153 of 153
Bioactive IGF-I Concentrations in Children on GH Therapy
Vilmann, L. S., Albrethsen, J., Petersen, J. H., Holmboe, S. A., Christiansen, P., Main, K. M., Cleemann, L. H., Hansen, K. H., Frystyk, J., Hagen, C. P., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf566 · Cited by 3
Postnatal management of growth failure in children born small for gestational age
Cardoso-Demartini, A. D. A., Boguszewski, M. C. D. S., & Alves, C. (2019) · Jornal de Pediatria (Versão em Português) · doi:10.1016/j.jpedp.2018.10.003 · Cited by 3
Kessler, L., Krause, J., Kraft, F., Amin, A. K., Fekete, G., Lengyel, A., Pinti, É., Kovács, Á. F., Lischka, A., Eggermann, K., et al. (2024) · Clinical Genetics · doi:10.1111/cge.14649 · Cited by 3
Global perspective on pediatric growth hormone registries: a systematic review
Eslami, P., Sayarifard, F., Safdari, R., Shahmoradi, L., & Karbasi, Z. (2022) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2022-0045 · Cited by 3
Ay, B., Doğan, Ö. A., Taylan, F., Marcelis, C., Abalı, S., Lim, J. Y., Malicdan, M. C. V., Cederroth, H., Cederroth, M., Botto, L. D., et al. (2025) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.64179 · Cited by 3
Critical paediatric bioethics and the treatment of short stature : an interdisciplinary study
Murano, M. C. (2019) · Linköping studies in arts and science · doi:10.3384/diss.diva-155772 · Cited by 3
“Surveillance is recommended for the risk of cancer, metabolic side effects (Cohen et al. 2008, Carel et al. 2012, Swerdlow et al. 2017), for a possible increase in mortality, and the risk of stroke (Carel et al. 2012, Poidvin et al. 2014).”
BackgroundTwo years in growth hormone 2017–18
Clayton, P., & Whatmore, A. J. (2019) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2019.10.003 · Cited by 3
Murray, P. G., & Clayton, P. (2019) · doi:10.1002/9781119152712.ch6 · Cited by 3
Efficacy, safety, and outcomes of growth hormone treatment in children with idiopathic short stature
Linglart, A., Dauber, A. N., Jorge, A. A. L., Luo, X., Ogata, T., & Savendahl, L. S. (2025) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2025.101661 · Cited by 2
Murano, M. C., Slatman, J., & Zeiler, K. (2018) · Medical Humanities · doi:10.1136/medhum-2018-011548 · Cited by 2
Growth Hormone As Antiaging Factor in Old Bones
Tresguerres, F. G. F., Tresguerres, I. F., Berrocal, M. I. L., Clemente, C., Rodríguez-Torres, R., Torres, J., Carballido, J., & Tresguerres, J. A. F. (2021) · Rejuvenation Research · doi:10.1089/rej.2020.2369 · Cited by 2
“21,48 Our study was carried out to clarify the effect of exogenous GH administration on bone metabolism, mechanical properties, bone areas, and BMD in 22-month-old female Wistar rats.”
Influence of growth hormone therapy on germinoma survivors
Kinoshita, Y., Yamasaki, F., Taguchi, A., Takayasu, T., Yonezawa, U., Tominaga, A., Arita, K., Okada, S., Horie, N., & Sugiyama, K. (2022) · Pituitary · doi:10.1007/s11102-022-01273-5 · Cited by 2
Puvilland, C. B., Villanueva, C., Hemmendinger, A., Kornreich, L., Gueorguieva, I., Karnoub, M., Beuriat, P.-A., & Leblond, P. (2022) · Cancers · doi:10.3390/cancers15010055 · Cited by 2
Herman-Bonert, V. S., & Melmed, S. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99899-4.00023-8 · Cited by 2
Growth hormone and gastrointestinal malignancy: An intriguing link
Palui, R., Sridharan, K., Kamalanathan, S., Sahoo, J., & Naik, D. (2023) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v14.i1.1 · Cited by 2
Sorteberg, A. L., Ek, L., Lilienthal, I., & Herold, N. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_236-1 · Cited by 2
Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study
Savendahl, L. S., Cooke, R., Tidblad, A., Beckers, D., Butler, G. E., Cianfarani, S., Clayton, P., Coste, J., Acs, H.-K., Kiess, W., et al. (2021) · Yearbook of pediatric endocrinology · doi:10.1530/ey.18.4.6 · Cited by 2
Recombinant human growth hormone: a medical miracle or cause for concern?
Subramanian, G. C., Yusoff, Y. M., Esa, E., Zakaria, Z., & Ponnampalam, S. N. (2018) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2018.5.1.0090 · Cited by 2
Thrifty Hormone Ghrelin: The Secret of Aging Muscularly.
Sun, Y. (2020) · PubMed · Cited by 2
Growth Hormone Deficiency in Children
Kriström, B., & Lundberg, E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.66108-1 · Cited by 2
Virú-Loza, M. A., & Chávez-Nomberto, R. E. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad054 · Cited by 2
Iughetti, L., Antoniazzi, F., Giavoli, C., Bellone, S., Aversa, T., Guazzarotti, L., Street, M. E., del Giudice, E. M., Persani, L., Pozzobon, G. C., et al. (2024) · Endocrine · doi:10.1007/s12020-024-04090-x · Cited by 1
“Data from the long-term Safety and Appropriateness of Growth Hormone treatments in Europe (SAGhE) cohort study have indicated that rhGH treatment in childhood is not associated with an increased risk of cancer [4].”
Zhang, C., Liang, Y., & Luo, X.-P. (2024) · World Journal of Pediatrics · doi:10.1007/s12519-024-00862-7 · Cited by 1
“Additionally, cancer risk was unrelated to the duration or cumulative dose of rhGH treatment, but for patients with previous cancer, the mortality risk of cancer increased significantly with increased doses of rhGH [12].”
Sorteberg, A. L., Ek, L., Lilienthal, I., & Herold, N. (2025) · Springer eBooks · doi:10.1007/978-3-032-00769-8_236 · Cited by 1
(2019) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2019.213 · Cited by 1
Growth hormone treatment in small for gestational age children. Experience in one center
Jiménez, A. B. A., García, C. P., & Moraño, C. D. L. C. (2023) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2022-02753.eng · Cited by 1
Turner syndrome: fertility, familial clustering, and cancer risk
Allen‐Brady, K., Verrilli, L. E., Austin, B., Letourneau, J. M., Johnstone, E. B., & Welt, C. K. (2024) · Human Reproduction · doi:10.1093/humrep/deae266 · Cited by 1
Krankheiten von Hypophyse und Hypothalamus bei Kindern und Jugendlichen
Pfäffle, R. W. (2020) · Springer Reference Medizin · doi:10.1007/978-3-642-54671-6_87-2
Statement of Argentine pediatric endocrinologists on growth hormone interchangeability
Alonso, G., Balbi, V. A., de Casella, C. B., Belgorosky, A., Bergadá, I., Brunetto, O., Cassinelli, H., Ciaccio, M., Keselman, A. C., Miras, M. B., et al. (2019) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2019.eng.213
60 years on, growth hormone inches its way to safety
Shalet, S. M. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30233-3
Backeljauw, P. F., Kanumakala, S., Loche, S., Schwab, K. O., Miller, B. S., Levy, R., McCormick, K. L., Zouater, H., Zabransky, M., & Campbell, K. (2021) · Research Square · doi:10.21203/rs.3.rs-896333/v1
Tonelli, F., Cotti, S., Leoni, L., Besio, R., Gioia, R., Marchese, L., Giorgetti, S., Villani, S., Gistelinck, C., Wagener, R., et al. (2021) · Yearbook of pediatric endocrinology · doi:10.1530/ey.18.5.11
Growth Disorders with No Defined Aetiology
George, M., & Chernausek, S. D. (2022) · doi:10.1093/med/9780198870197.003.0183
Krankheiten von Hypophyse und Hypothalamus
Pfäffle, R. W. (2020) · Springer Reference Medizin · doi:10.1007/978-3-662-60300-0_87
Cancer Risk After Growth Hormone Therapy
(2017) · AAP Grand Rounds · doi:10.1542/gr.37-6-71
Raine, J., MBChB, J. W. G., Vliet, G. V., MB, B. J. I. W., & Deladoëy, J. (2019) · Wiley eBooks · doi:10.1002/9781119386230.ch3
Conducta práctica ante una anomalía del crecimiento
Bouvattier, C. M., & Lambert, A.-S. (2022) · EMC - Tratado de Medicina · doi:10.1016/s1636-5410(22)47178-9
Pediatric disorders of stature
Greene, E., & Benjamin, R. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-818872-9.00132-1
(2023) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2022-02753
Quarde, A. (2023) · doi:10.1002/9781119863564.ch1
Case Report: Plummer's adenoma in Prader–Willi syndrome
Corica, D., Toscano, F., Moleti, M., Pepe, G., Campennì, A., Fadda, G., Dionigi, G., Romeo, C., Aversa, T., & Wasniewska, M. G. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2024.1388437
Retraso de crecimiento en niños
Lambert, A.-S., & Linglart, A. (2024) · EMC - Pediatría · doi:10.1016/s1245-1789(24)49743-6
Management of Acute and Late Endocrine Effects of Childhood Cancer Treatment
Boguszewski, M. C. D. S., & Cardoso-Demartini, A. D. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-66296-6_38
Management of Adults with Childhood-Onset Growth Hormone Deficiency
Paragliola, R. M., & Salvatori, R. (2024) · Springer eBooks · doi:10.1007/978-3-031-66296-6_7
History and Current Status of Growth Hormone Treatment in Children
Luz, C., & Collett‐Solberg, P. F. (2025) · Pediatric Drugs · doi:10.1007/s40272-025-00721-6
“…did not support a carcinogenic effect of rhGH, but there was an unexplained trend in cancer mortality risk in relation to GH dose in patients with previous cancer and an indication of possible effects on bone cancer, bladder cancer, and Hodgkin lymphoma risks, requiring further investigation [60].”
Wang, G., Wang, M., Wang, J., Zhang, Z., Allegaert, K., Zhang, Y., Luo, S., Fang, Y., Chen, Y., Wei, H., et al. (2025) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2025-003741
Coutant, R., Benchikh, N., Linglart, A., Nicolino, M. P., & Salles, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1656966
Turner disease: A contemporary clinical approach
Tančić‐Gajić, M., Tesla, B., Miletić, M., Stojanovic, M. M., & Vujović, S. (2025) · Medicinska istrazivanja · doi:10.5937/medi0-57350
Long, A. S., & Lee, J. C. (2025) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000012292
Precision Dosing for Pediatric Growth Hormone Deficiency With Daily and Weekly Growth Hormone
Wu, W., Gong, C., Mei, J., Hou, L., Liang, Y., Ying, Y., Ye, F., Ju, G., Tian, H., Yang, N., et al. (2026) · MedComm · doi:10.1002/mco2.70945
Genetics of Premature Ovarian Insufficiency: From Molecular Architecture to Precision Medicine
Sousa, V., Livera, G., & Misrahi, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198662
“In patients with demonstrated chromosomal instability, GH therapy should be avoided or regarded as contraindicated according to specialist recommendations because stimulation of cell proliferation may increase tumor risk [67].”
Metadata
- Authors
- Swerdlow, A. J., Cooke, R., Beckers, D., Borgström, B., Butler, G., Carel, J.-C., Cianfarani, S., Clayton, P., Coste, J., Deodati, A., Ecosse, E., Gausche, R., Giacomozzi, C., Hokken-Koelega, A. C. S., Khan, A. J., Kiess, W., Kuehni, C. E., Mullis, P.-E., Pfaffle, R., Sävendahl, L., Sommer, G., Thomas, M., Tidblad, A., Tollerfield, S., Van Eycken, L., & Zandwijken, G. R. J.
- Affiliations
- Institute of Cancer Research (GB)
- UCLouvain (BE)
- Karolinska Institutet (SE)
- National Health Service (GB)
- Inserm (FR)
- University of Rome Tor Vergata (IT)
- Leipzig University (DE)
- Azienda Ospedaliera Carlo Poma (IT)
- Erasmus MC (NL)
- University of Bern (CH)
- University Hospital of Bern (CH)
- University College London (GB)
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2017-02-10
- Volume
- 102
- Issue
- 5
- Pages
- 1661-1672
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC6061931
- OpenAlex
- W2597357044
- Cited by
- 153
- References
- 31
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 16 · 2023: 14 · 2022: 23 · 2021: 16 · 2020: 19 · 2019: 26 · 2018: 18 · 2017: 6
- FWCI
- 14.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
- Digital Access to Libraries (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, cc-by)
- Open Access CRIS of the University of Bern
- Funders
- Eli Lilly and Company
- Pfizer
- University College London
- European Commission (223497)
- Cancerfonden
- Novo Nordisk
- Vetenskapsrådet
- Barncancerfonden
- Institut National Du Cancer
- Agence Française de Sécurité Sanitaire des Produits de Santé
- Ipsen
- Novo Nordisk Pharma
- FP7 Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Epidemiology › Multiple and Secondary Primary Cancers
- Keywords
- recombinant human growth hormone, cancer risk, second primary malignancy, cancer mortality, cancer incidence, Hodgkin's disease, bone cancer, bladder cancer, growth hormone dose
- MeSH terms
- Adolescent, Urinary Bladder Neoplasms, Bone Diseases, Developmental, Bone Neoplasms, Child, Child, Preschool, Dose-Response Relationship, Drug, Europe, Female, Growth Disorders, Hodgkin Disease, Humans, Hypopituitarism, Infant, Infant, Newborn, Male, Neoplasms, Recombinant Proteins, Risk, Turner Syndrome, Cohort Studies, Incidence, Neoplasms, Second Primary, Human Growth Hormone, Renal Insufficiency, Chronic, Young Adult
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