The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline
Abstract
Cosponsoring Associations: The American Society for Reproductive Medicine, the European Society of Endocrinology, and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. Objective: To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA). Participants: The participants include an Endocrine Society-appointed task force of eight experts, a methodologist, and a medical writer. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence. The task force commissioned two systematic reviews and used the best available evidence from other published systematic reviews and individual studies. Consensus Process: One group meeting, several conference calls, and e-mail communications enabled consensus. Endocrine Society committees and members and cosponsoring organizations reviewed and commented on preliminary drafts of this guideline. Conclusions: FHA is a form of chronic anovulation, not due to identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or a combination thereof. Investigations should include assessment of systemic and endocrinologic etiologies, as FHA is a diagnosis of exclusion. A multidisciplinary treatment approach is necessary, including medical, dietary, and mental health support. Medical complications include, among others, bone loss and infertility, and appropriate therapies are under debate and investigation.
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Cites
Grading quality of evidence and strength of recommendations
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“After 6 months of amenorrhea, clinicians should consider a baseline DXA evaluation in any adolescent or woman with FHA (45, 53, 64, 65).”
BackgroundFrisch, R. E., & McArthur, J. W. (1974) · Science · doi:10.1126/science.185.4155.949 · Cited by 1,412
Criteria, Prevalence, and Phenotypes of Polycystic Ovary Syndrome
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“Clinicians should obtain total or free testosterone levels (depending on assay reliability and noting that the former is usually more accurate) (135).”
BackgroundRecombinant human leptin in women with hypothalamic amenorrhea
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Cited by
Polycystic Ovary Syndrome: Definition, Aetiology, Diagnosis and Treatment
Escobar-Morreale, H. F. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.24 · Cited by 2,083
IOC consensus statement on relative energy deficiency in sport (RED-S): 2018 update
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Energy Availability in Athletics: Health, Performance, and Physique
Melin, A. K., Heikura, I. A., Tenforde, A., & Mountjoy, M. (2019) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0201 · Cited by 258
Metadata
- Authors
- Gordon, C. M., Ackerman, K. E., Berga, S. L., Kaplan, J. R., Mastorakos, G., Misra, M., Murad, M. H., Santoro, N. F., & Warren, M. P.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2017-03-22
- Volume
- 102
- Issue
- 5
- Pages
- 1413-1439
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2607394025
- Cited by
- 600
- References
- 24
- FWCI
- 40.81
- Type
- journal article
- Language
- en
- Open access
- closed
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