Increased Triacylglycerol Lipase Activity in Adipose Tissue of Lean and Obese Men During Endurance Exercise
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Context: Although there is increasing information on the mechanism of lipolysis in adipose tissue, the effect of exercise on individual factors of lipolysis is less well understood. Objective: We compared changes in adipose-tissue triacylglycerol lipase activity and gene expression of adipose triacylglycerol lipase (ATGL), hormone-sensitive lipase (HSL), monoacylglycerol lipase, perilipin 1, and comparative gene identification 58 (CGI-58) during exercise between lean and obese men. Design and Participants: Seven lean and nine obese men cycled for 30 minutes at a heart rate of 130 to 140 beats per minute. At baseline and 5, 10, 20, and 30 minutes of exercise, we sampled subcutaneous adipose tissue for triacylglycerol lipase activity and mRNA determination, and blood for glycerol, nonesterified fatty acid, glucose, lactate, insulin, and catecholamine determination. Setting: The study was conducted at a university research unit. Results: Triacylglycerol lipase activity increased at 10 minutes of exercise in the lean men and returned to baseline at 20 and 30 minutes. In the obese men, it was higher than baseline at 10, 20, and 30 minutes and higher than the corresponding values in the lean men at 20 and 30 minutes. No changes in mRNA levels were found during exercise, but the obese men had lower mRNA levels of ATGL, HSL, and CGI-58 compared with the lean men. Conclusion: Our findings suggest different patterns of lipolytic stimulation during endurance exercise between lean and obese men. Differences in lipolytic rates seem to be due to differences in protein amount or activity, not mRNA levels.
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Women with upper body obesity show reduced FFA release during exercise compared to non-obese or lower body obese women.
“Concerning body composition, women with upper body obesity show reduced FFA release during exercise compared to non-obese or lower body obese women (231, 232).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [231]
The Discussion reports that some studies found lower exercise-induced lipolysis in obesity, which supports the broad direction of the claim. But this paper studied lean and obese men, not women grouped by upper- and lower-body obesity, and reports no difference in circulating nonesterified fatty acids between its groups. It does not establish the claimed comparison among women. (LLM, conf=0.78)
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References 31 · Cited by 37
- Authors
- Petridou, A., Chatzinikolaou, A., Avloniti, A., Jamurtas, A., Loules, G., Papassotiriou, I., Fatouros, I., & Mougios, V.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- Democritus University of Thrace (GR)
- University of Thessaly (GR)
- Children's Hospital Agia Sophia (GR)
- Corresponding author
- Petridou, Anatoli
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2017-06-12
- Volume
- 102
- Issue
- 11
- Pages
- 3945-3952
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2626199106
- Cited by
- 37
- References
- 31
- Citations by year
- 2025: 5 · 2024: 12 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 1
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
- Funders
- Aristotle University of Thessaloniki
- Research Committee, Aristotle University of Thessaloniki
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- triacylglycerol lipase, lipolysis, adipose tissue, endurance exercise, obesity, lean men, adipose triglyceride lipase, hormone-sensitive lipase, CGI-58, PLIN1, monoacylglycerol lipase, gene expression, subcutaneous adipose tissue, free fatty acids, glycerol
- MeSH terms
- Acyltransferases, Adipose Tissue, Adult, Exercise Therapy, Humans, Lipase, Male, Obesity, Physical Endurance, Thinness, Exercise, 1-Acylglycerol-3-Phosphate O-Acyltransferase, Young Adult
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