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S-25OHD Is Associated With Hand Grip Strength and Myopathy at 5 Years in Girls: An Odense Child Cohort Study

Al-Jwadi, Rada Faris, Jespersen, Eva, Dalgård, Christine, Bilenberg, Niels, Christesen, Henrik Thybo·2018·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2018-00281
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Abstract

Context: Severe vitamin D deficiency may lead to myopathy in adults. Little is known about vitamin D and muscle strength in children. Objective: To test whether hand grip strength (HGS) in 5-year-old children is associated with serum 25-hydroxyvitamin D (S-25OHD). Design: Observational study in the population-based Odense Child Cohort, Denmark. At 5 years, anthropometrics, body fat percentage by skinfold measurements, HGS (n = 881), and S-25OHD2+3 (n = 499) were obtained. Results: Mean (SD) HGS was higher for boys compared with girls [8.76 (1.76) vs 8.1 (1.64) kg, P < 0.001]. Mean (SD) 5-year S-25OHD was 70.7 (24.5) nmol/L. HGS was directly associated with height in girls and with weight (directly) and body fat percentage (inversely) in both sexes (P < 0.01 for all). In girls, 5-year S-25OHD was associated with HGS, adjusting for height, weight, and body fat percentage [β = 0.011 (95% CI: 0.004; 0.019), P = 0.003]. S-25OHD ≥75 nmol/L was associated with higher HGS compared with values <50 nmol/L [adjusted β = 0.783 (95% CI: 0.325; 1.241), P = 0.001]. The odds of having myopathy (HGS <10th percentile) were reduced by approximately 70% for S-25OHD ≥50 vs <50 nmol/L [adjusted OR: 0.310 (95% CI: 0.126; 0.762), P = 0.011]. No associations were seen for boys. Pregnancy or umbilical cord S-25OHD did not associate with 5-year HGS. Conclusions: Five-year S-25OHD was independently associated with HGS and myopathy in girls but not in boys. Muscle strength may be dependent on vitamin D status even in the higher range in preschool girls. The sex difference remains unexplained.

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Metadata

Authors
Al-Jwadi, R. F., Jespersen, E., Dalgård, C., Bilenberg, N., & Christesen, H. T.
Affiliations
  • Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense C, Denmark
  • Department of Rehabilitation and Research, Odense University Hospital, Odense C, Denmark
  • Department of Public Health—Environmental Medicine, University of Southern Denmark, Odense C, Denmark
  • Department of Child and Adolescent Mental Health, Mental Health Services in the Region of Southern Denmark, University of Southern Denmark, Odense C, Denmark
  • Hans Christian Andersen Children’s Hospital, Odense University Hospital, Odense C, Denmark
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2018-05-16
Volume
103
Issue
7
Pages
2630-2639
ISSN
  • 0021-972X
  • 1945-7197
DOI
10.1210/jc.2018-00281
Cited by
11
References
3
Language
en

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CoChat. (2026). Citation check: S-25OHD Is Associated With Hand Grip Strength and Myopathy at 5 Years in Girls: An Odense Child Cohort Study. https://app.cochat.ai/papers/10.1210/jc.2018-00281
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Al-Jwadi, R. F., Jespersen, E., Dalgård, C., Bilenberg, N., & Christesen, H. T. (2018). S-25OHD Is Associated With Hand Grip Strength and Myopathy at 5 Years in Girls: An Odense Child Cohort Study. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2018-00281

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