The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Primary Hyperparathyroidism
Open accessAbstract
Background: Primary hyperparathyroidism (PHPT), the most common cause of hypercalcemia, is most often identified in postmenopausal women. The clinical presentation of PHPT has evolved over the past 40 years to include three distinct clinical phenotypes, each of which has been studied in detail and has led to evolving concepts about target organ involvement, natural history, and management. Methods: In the present review, I provide an evidence-based summary of this disorder as it has been studied worldwide, citing key concepts and data that have helped to shape our concepts about this disease. Results: PHPT is now recognized to include three clinical phenotypes: overt target organ involvement, mild asymptomatic hypercalcemia, and high PTH levels with persistently normal albumin-corrected and ionized serum calcium values. The factors that determine which of these clinical presentations is more likely to predominate in a given country include the extent to which biochemical screening is used, vitamin D deficiency is present, and whether parathyroid hormone levels are routinely measured in the evaluation of low bone density or frank osteoporosis. Guidelines for parathyroidectomy apply to all three clinical forms of the disease. If surgical guidelines are not met, parathyroidectomy can also be an appropriate option if no medical contraindications are present. If either the serum calcium or bone mineral density is of concern and surgery is not an option, pharmacological approaches are available and effective. Conclusions: Advances in our knowledge of PHPT have guided new concepts in diagnosis and management.
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Cites
Bilezikian, J. P., Khan, A. A., & Potts, J. T. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1763 · Cited by 1,521
Self-citationHypovitaminosis D in Medical Inpatients
Thomas, M. K., Lloyd-Jones, D. M., Thadhani, R. I., Shaw, A. C., Deraska, D. J., Kitch, B. T., Vamvakas, E. C., Dick, I. M., Prince, R. L., & Finkelstein, J. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803193381201 · Cited by 1,423
Bilezikian, J. P., Brandi, M. L., Eastell, R., Silverberg, S. J., Udelsman, R., Marcocci, C., & Potts, J. T. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1413 · Cited by 1,271
Self-citationThe Parathyroid Glands and Metabolic Bone Disease
WILKINS, L. (1949) · Pediatrics · doi:10.1542/peds.3.4.573 · Cited by 923
Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image
Silva, B. C., Leslie, W. D., Resch, H., Lamy, O., Lesnyak, O., Binkley, N., McCloskey, E. V., Kanis, J. A., & Bilezikian, J. P. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2176 · Cited by 841
Self-citationBilezikian, J. P., Potts, J. T., Fuleihan, G. E.-H., Kleerekoper, M., Neer, R., Peacock, M., Rastad, J., Silverberg, S. J., Udelsman, R., & Wells, S. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021370 · Cited by 770
Self-citationIncidence and Prevalence of Primary Hyperparathyroidism in a Racially Mixed Population
Yeh, M. W., Ituarte, P. H. G., Zhou, H. C., Nishimoto, S., Amy Liu, I.-L., Harari, A., Haigh, P. I., & Adams, A. L. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4022 · Cited by 742
Skeletal disease in primary hyperparathyroidism
Silverberg, S. J., Shane, E., de la Cruz, L., Dempster, D. W., Feldman, F., Seldin, D., Jacobs, T. P., Siris, E. S., Cafferty, M., Parisien, M. V., et al. (1989) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650040302 · Cited by 625
Rubin, M. R., Bilezikian, J. P., McMahon, D. J., Jacobs, T., Shane, E., Siris, E., Udesky, J., & Silverberg, S. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1215 · Cited by 593
Self-citationKhan, A. A., Hanley, D. A., Rizzoli, R., Bollerslev, J., Young, J. E. M., Rejnmark, L., Thakker, R., D’Amour, P., Paul, T., Van Uum, S., et al. (2017) · Osteoporosis International · doi:10.1007/s00198-016-3716-2 · Cited by 544
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Cited by
Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota
Li, J.-Y., Yu, M., Pal, S., Tyagi, A. M., Dar, H., Adams, J., Weitzmann, M. N., Jones, R. M., & Pacifici, R. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133473 · Cited by 198
PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells
Yu, M., Malik Tyagi, A., Li, J.-Y., Adams, J., Denning, T. L., Weitzmann, M. N., Jones, R. M., & Pacifici, R. (2020) · Nature Communications · doi:10.1038/s41467-019-14148-4 · Cited by 148
Metadata
- Authors
- Bilezikian, J. P.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2018-07-27
- Volume
- 103
- Issue
- 11
- Pages
- 3993-4004
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W4211017093
- Cited by
- 325
- References
- 70
- FWCI
- 19.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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