The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Adrenal incidentaloma and patients with homozygous or heterozygous congenital adrenal hyperplasia.
Abstract
Adrenal tumors are being detected more frequently in consequence of the wider application of increasingly sensitive radiological investigation techniques. According to the working hypothesis that more silent adenomas could develop from hyperplastic tissue areas under increased stimulation of the adrenal cortex, heterozygous and homozygous patients with congenital adrenal hyperplasia (CAH) were studied. A high incidence of adrenal masses, nearly 82% in homozygous and 45% in heterozygous patients, was found. There was no correlation between tumor size and serum 17-hydroxyprogesterone concentrations. These tumors are, therefore, probably silent adenomas. On the basis of these results, CAH should always be ruled out in the case of incidentally detected adrenal masses. Since CAH is a relatively frequent disease, and the adrenal carcinoma belongs to the rarest malignant tumors, a malignant transformation of these tumors seems to be unlikely.
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“Most patients diagnosed with NC CAH are females suffering from mild adrenal androgen excess without clinically relevant deficiencies of gluco-and mineralocorticoids (134,429).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [429]
In the citing paper
“In rare cases, severe acne, reduced fertility or adrenal incidentaloma lead to the diagnosis of NC CAH in men (429).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [429]
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Genotyping steroid 21-hydroxylase deficiency: hormonal reference data
NEW, M. I., LORENZEN, F., LERNER, A. J., KOHN, B., OBERFIELD, S. E., POLLACK, M. S., DUPONT, B., STONER, E., LEVY, D. J., PANG, S., et al. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-2-320 · Cited by 624
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Fassnacht, M., Arlt, W., Bancos, I., Dralle, H., Newell-Price, J., Sahdev, A., Tabarin, A., Terzolo, M., Tsagarakis, S., & Dekkers, O. M. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0467 · Cited by 1,566
Speiser, P. W., Azziz, R., Baskin, L. S., Ghizzoni, L., Hensle, T. W., Merke, D. P., Meyer-Bahlburg, H. F. L., Miller, W. L., Montori, V. M., Oberfield, S. E., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2631 · Cited by 1,468
Speiser, P. W., Arlt, W., Auchus, R. J., Baskin, L. S., Conway, G. S., Merke, D. P., Meyer-Bahlburg, H. F. L., Miller, W. L., Murad, M. H., Oberfield, S. E., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01865 · Cited by 1,234
The clinically inapparent adrenal mass: update in diagnosis and management
Mansmann, G., Lau, J., Balk, E., Rothberg, M., Miyachi, Y., & Bornstein, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0031 · Cited by 781
Prevalence and natural history of adrenal incidentalomas
Barzon, L., Sonino, N., Fallo, F., Palu, G., & Boscaro, M. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490273 · Cited by 642
Metadata
- Authors
- Jaresch, S., Kornely, E., Kley, H. K., & Schlaghecke, R.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1992-03
- Volume
- 74
- Issue
- 3
- Pages
- 685-689
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2037425536
- Cited by
- 227
- References
- 1
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 12 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 6
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- adrenal incidentaloma, congenital adrenal hyperplasia, adrenal mass, 17-hydroxyprogesterone, adrenal adenoma, adrenocortical carcinoma, tumor size, adrenal hyperplasia
- MeSH terms
- Adrenal Gland Neoplasms, Adrenal Hyperplasia, Congenital, Adrenocorticotropic Hormone, Adult, Cortodoxone, Dehydroepiandrosterone, Female, Heterozygote, Homozygote, Humans, Hydroxyprogesterones, Male, Tomography, X-Ray Computed, 17-alpha-Hydroxyprogesterone
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