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Cited by 263

The DOI matches its OpenAlex record.

Tumor Necrosis Factor Increases Serum Leptin Levels in Humans

Open access
Martina Susanne Zumbach, Michael W. J. Boehme, Peter M. Wahl, Wolfgang Stremmel, Reinhard Ziegler, Peter P. Nawroth·1997·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.82.12.4080
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Abstract

Leptin is a pleiotropic hormone believed to regulate body weight. Its function in wasting during inflammatory disease in humans is unknown. We studied the effect of repeated tumor necrosis factor (TNF) infusion on serum leptin levels in six patients with solid tumors. TNF infusion on day 1 resulted in an increase in serum leptin levels from 3.1 (SEM +/- 0.28) ng/mL to 5.2 (SEM +/- 0.6) ng/mL after 12 h (P < 0.001). The serum levels returned to baseline within 24 h. Similar results were obtained when TNF was infused on subsequent days. The study shows that leptin serum levels are under control of TNF.

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Metadata

Authors
Zumbach, M. S., Boehme, M. W. J., Wahl, P. M., Stremmel, W., Ziegler, R., & Nawroth, P. P.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
Oxford University Press
Published
1997-12-01
Volume
82
Issue
12
Pages
4080-4082
ISSN
0021-972X (ISSN-L)
DOI
10.1210/jc.82.12.4080
OpenAlex
W2160885977
Cited by
263
References
0
FWCI
6.06
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.