The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A Healthy Body in a Healthy Mind--and Vice Versa--The Damaging Power of "Uncontrollable" Stress
Abstract
The hypothalamic-pituitary-adrenal (HPA) axis together with the sympathetic system connect the brain with the periphery of the body (1) (Fig. 1). The central nervous system (CNS) centers of the HPA axis and the sympathetic system are, respectively, the parvicellular corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP) neurons of the paraventricular nuclei of the hypothalamus and the noradrenergic neurons of the locus ceruleus/norepinephrine (LC/NE) nuclei of the brain stem. These neuronal centers innervate and stimulate each other and have both a baseline circadian and stress-related activity. The CRH/AVP and LC/NE neurons and their peripheral axes are heuristically known as the stress system. The secretion of the end-product of the HPA axis, cortisol, is kept by an elaborate negative feedback system within an optimal time-integrated narrow range, which is quite stable in an individual subject. That the body would have such a tightly regulated servo-control system suggests that excessive, unchecked activity could be detrimental to the organism.
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Citations
Cites
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
Self-citationThe Pathophysiologic Roles of Interleukin-6 in Human Disease
Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00009 · Cited by 1,146
Self-citationBone Mineral Density in Women with Depression
Michelson, D., Stratakis, C., Hill, L., Reynolds, J., Galliven, E., Chrousos, G., & Gold, P. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351602 · Cited by 471
Self-citationKarl, M., Lamberts, S. W., Detera-Wadleigh, S. D., Encio, I. J., Stratakis, C. A., Hurley, D. M., Accili, D., & Chrousos, G. P. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.3.8445027 · Cited by 241
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Cited by
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
Tsigos, C., & Chrousos, G. P. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00429-4 · Cited by 2,822
Self-citationInflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775
Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274
Self-citationThe cortisol awakening response (CAR): Facts and future directions
Fries, E., Dettenborn, L., & Kirschbaum, C. (2009) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2008.03.014 · Cited by 1,188
The influence of bio-behavioural factors on tumour biology: pathways and mechanisms
Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., Stefanek, M., & Sood, A. K. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1820 · Cited by 981
Metadata
- Authors
- Chrousos, G. P.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1998-06-01
- Volume
- 83
- Issue
- 6
- Pages
- 1842-1845
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2106749899
- Cited by
- 297
- References
- 5
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- closed
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