In Vitro Secretion of Cytokines by Human Bone Marrow: Effects of Age and Estrogen Status

Changes in Proinflammatory Cytokine Activity after Menopause

Pfeilschifter, J., Köditz, R., Pfohl, M., & Schatz, H. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0456 · Cited by 911 · see citing works

Age‐related intrinsic changes in human bone‐marrow‐derived mesenchymal stem cells and their differentiation to osteoblasts

Zhou, S., Greenberger, J. S., Epperly, M. W., Goff, J. P., Adler, C., LeBoff, M. S., & Glowacki, J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00377.x · Cited by 782 · see citing works

Playing with bone and fat

Gimble, J. M., Zvonic, S., Floyd, Z. E., Kassem, M. S., & NUTTALL, M. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20777 · Cited by 505 · see citing works

Age‐related decline in the osteogenic potential of human bone marrow cells cultured in three‐dimensional collagen sponges

Mueller, S. M., & Glowacki, J. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1174 · Cited by 441 · see citing works

T cells and aging january 2002 update

Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 368 · see citing works

Association of circulating TNF-α and IL-6 with ageing and parkinsonism

Dobbs, R. J., Charlett, A., Purkiss, A. G., Dobbs, S. M., Weller, C., & Peterson, D. W. (1999) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1999.tb00721.x · Cited by 324 · see citing works

Ageing of lymphocytes and lymphocytes in the aged

Globerson, A., & Effros, R. B. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01714-x · Cited by 309 · see citing works

Influence of sex hormones on the periodontium

Mascarenhas, P., Gapski, R., Al‐Shammari, K. F., & Wang, H. (2003) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2003.00055.x · Cited by 270 · see citing works

Complex Actions of Sex Steroids in Adipose Tissue, the Cardiovascular System, and Brain: Insights from Basic Science and Clinical Studies

Turgeon, J. L., Carr, M. C., Maki, P. M., Mendelsohn, M. E., & Wise, P. M. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0020 · Cited by 263 · see citing works

Cytokines, bone remodeling, and estrogen deficiency: a 1998 update

Jilka, R. L. (1998) · Bone · doi:10.1016/s8756-3282(98)00077-5 · Cited by 255 · see citing works

Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age‐associated microenvironmental changes

Stout, R. D., & Suttles, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00260.x · Cited by 220 · see citing works

Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model

Sepúlveda, J. C., Tomé, M., Fernández‐Santos, M. E., Delgado, M., Campisi, J., Bernad, A., & Gonzalez, M. A. (2014) · Stem Cells · doi:10.1002/stem.1654 · Cited by 191 · see citing works

Effects of endogenous sex hormones on the periodontium — Review of literature

Güncü, G. N., Tözüm, T. F., & Çağlayan, F. (2005) · Australian Dental Journal · doi:10.1111/j.1834-7819.2005.tb00352.x · Cited by 186 · see citing works

Interleukin-6 Production Does Not Increase With Age

Beharka, A. A., Meydani, M., Wu, D., Leka, L. S., Meydani, A., & Meydani, S. N. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.2.b81 · Cited by 169 · see citing works

Molecular mechanisms underlying osteoclast formation and activation

Troen, B. R. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00069-x · Cited by 147 · see citing works

Is obesity in women protective against osteoporosis?

Migliaccio, S., Greco, E. A., Fornari, F., Donini, L. M., & Lenzi (2011) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s11920 · Cited by 137 · see citing works

T cells and aging (update February 1999)

Pawelec, G. (1999) · Frontiers in bioscience · doi:10.2741/pawelec · Cited by 138 · see citing works

Effect of Age on Regulation of Human Osteoclast Differentiation

Chung, P., Zhou, S., Eslami, B., Shen, L., LeBoff, M. S., & Glowacki, J. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24792 · Cited by 116 · see citing works

CHANGES IN IMMUNE FUNCTION WITH AGE

Yung, R. L. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70151-4 · Cited by 96 · see citing works

Rescuing mesenchymal stem cell regenerative properties on hydrogel substrates post serial expansion

Rao, V. V., Vu, M. K., Ma, H., Killaars, A. R., & Anseth, K. S. (2018) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10104 · Cited by 80 · see citing works

Reproductive Factors and Risk of Intermediate- or High-Grade B-Cell Non-Hodgkin’s Lymphoma in Women

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Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform

Waters, K. M., Rickard, D. J., Riggs, B. L., Khosla, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Moore, J. T., & Spelsberg, T. C. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1242 · Cited by 73 · see citing works

Hematopoietic stem cells and aging

Globerson, A. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00069-2 · Cited by 66 · see citing works

The “lively” cytokines network in β-Thalassemia Major-related osteoporosis

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Immune senescence: significance of the stromal microenvironment

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Role of reproductive factors in hepatocellular carcinoma: Impact on hepatitis B– and C–related risk

Yu, M. (2003) · Hepatology · doi:10.1053/jhep.2003.09041 · Cited by 58 · see citing works

Vitamin D metabolism in human bone marrow stromal (mesenchymal stem) cells

Geng, S., Zhou, S., Bi, Z., et al. (2013) · Metabolism · doi:10.1016/j.metabol.2013.01.003 · Cited by 50 · see citing works

Cytokine Changes in Postmenopausal Women Treated with Estrogens: a Placebo‐controlled Study

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Oestrogens prevent the increase of human serum soluble interleukin‐6 receptor induced by ovariectomy in vivo and decrease its release in human osteoblastic cells in vitro

Girasole, G., Giuliani, N., Modena, A. B., et al. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00896.x · Cited by 46 · see citing works

gp130 signaling in bone cell biology: Multiple roles revealed by analysis of genetically altered mice

Sims, N. A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.08.025 · Cited by 43 · see citing works

The impact of chronic estrogen deprivation on immunologic parameters in the ovariectomized rhesus monkey (Macaca mulatta) model of menopause

Keller, E. T., Zhang, J., Yao, Z., & Qi, Y. (2001) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(00)00087-5 · Cited by 44 · see citing works

Correlation of estradiol, parathyroid hormone, interleukin-6, and soluble interleukin-6 receptor during the normal menstrual cycle

Chiu, K. M., Arnaud, C. D., Ju, J., Mayes, D. M., Bacchetti, P., Weitz, S., & Keller, E. T. (2000) · Bone · doi:10.1016/s8756-3282(99)00243-4 · Cited by 42 · see citing works

Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice

Halade, G. V., Rahman, M. M., Williams, P. J., & Fernandes, G. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.03.015 · Cited by 44 · see citing works

Reduced Osteoclastogenesis and RANKL Expression in Marrow from Women Taking Alendronate

Eslami, B., Zhou, S., van Eekeren, I. C. M., LeBoff, M. S., & Glowacki, J. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9473-5 · Cited by 43 · see citing works

Menstrual and Reproductive Factors and Risk of Non-Hodgkin's Lymphoma among Connecticut Women

Zhang, Y. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh278 · Cited by 42 · see citing works

Interleukin‐6 induces the lineage commitment of bone marrow‐derived mesenchymal multipotent cells through down‐regulation of Sox2 by osteogenic transcription factors

Yoon, D. S., Kim, Y. H., Lee, S., Lee, K., Park, K. H., Jang, Y., & Lee, J. W. (2014) · The FASEB Journal · doi:10.1096/fj.13-248567 · Cited by 41 · see citing works

The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis

Hadji, P., Coleman, R. E., Gnant, M., & Green, J. (2012) · Annals of Oncology · doi:10.1093/annonc/mds169 · Cited by 40 · see citing works

Increased mRNA expression and protein secretion of interleukin‐6 in primary human osteoblasts differentiated in vitro from rheumatoid and osteoarthritic bone

Chenoufi, H.-L., Diamant, M., Rieneck, K., Lund, B., Stein, G. S., & Lian, J. B. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1104 · Cited by 39 · see citing works

Effects of age and gender on WNT gene expression in human bone marrow stromal cells

Shen, L., Zhou, S., & Glowacki, J. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22010 · Cited by 39 · see citing works

Effects of Vitamin E on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats

Feresin, R. G., Johnson, S. A., Elam, M. L., Kim, J., Khalil, D. A., Lucas, E. A., Smith, B. J., Payton, M. E., Akhter, M. P., & Arjmandi, B. H. (2013) · Journal of Osteoporosis · doi:10.1155/2013/825985 · Cited by 36 · see citing works

Hormone replacement therapy in cancer survivors

Biglia, N., Gadducci, A., Ponzone, R., Roagna, R., & Sismondi, P. (2004) · Maturitas · doi:10.1016/j.maturitas.2003.09.031 · Cited by 37 · see citing works

A Cautionary Tale for Autologous Vascular Tissue Engineering: Impact of Human Demographics on the Ability of Adipose-Derived Mesenchymal Stem Cells to Recruit and Differentiate into Smooth Muscle Cells

Krawiec, J. T., Weinbaum, J. S., Croix, C. M. S., Phillippi, J. A., Watkins, S. C., Rubin, J. P., & Vorp, D. A. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0208 · Cited by 34 · see citing works

Differential impact of nicotine on cellular proliferation and cytokine production by LPS-stimulated murine splenocytes

Hakki, A., Hallquist, N. A., Friedman, H. P., et al. (2000) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(00)00005-9 · Cited by 29 · see citing works

Formation of osteoclast‐like cells from peripheral blood of periodontitis patients occurs without supplementation of macrophage colony‐stimulating factor

Tjoa, S., de Vries, T. J., Schoenmaker, T., Kelder, A., Loos, B. G., & Everts, V. E. (2008) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2008.01241.x · Cited by 28 · see citing works

Functional proteome of bones in rats with osteoporosis following ovariectomy

Fan, Y., Liu, J., Wang, S., Wang, H., Shi, F., Xiong, L., He, W., & Peng, X. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.10.059 · Cited by 27 · see citing works

Dynamic bioinspired coculture model for probing ER + breast cancer dormancy in the bone marrow niche

Pradhan, L., Moore, D. L., Ovadia, E. M., Swedzinski, S. L., Cossette, T. L., Sikes, R. A., van Golen, K., & Kloxin, A. M. (2023) · Science Advances · doi:10.1126/sciadv.ade3186 · Cited by 24 · see citing works

Awakening of Dormant Breast Cancer Cells in the Bone Marrow

Wieder, R. (2023) · Cancers · doi:10.3390/cancers15113021 · Cited by 25 · see citing works

The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments

Venkatesh, V. S., Grossmann, M., Zajac, J. D., & Davey, R. A. (2022) · Obesity Reviews · doi:10.1111/obr.13429 · Cited by 22 · see citing works

The role of vitamin E in reversing bone loss

Chai, S. C., Wei, C., Brummel‐Smith, K., & Arjmandi, B. H. (2008) · Aging Clinical and Experimental Research · doi:10.1007/bf03324879 · Cited by 21 · see citing works

Parity, age at first birth, and risk of death from liver cancer: Evidence from a cohort in Taiwan

Wu, C., Chan, T., ChangChien, C., et al. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06365.x · Cited by 20 · see citing works

Analysis of fatty acid composition in human bone marrow aspirates

Deshimaru, R., Ishitani, K., Makita, K., et al. (2005) · The Keio Journal of Medicine · doi:10.2302/kjm.54.150 · Cited by 19 · see citing works

Effects of long‐term administration of N‐3 polyunsaturated fatty acids (PUFA) and selective estrogen receptor modulator (SERM) derivatives in ovariectomized (OVX) mice

Zeitlin, L., Segev, E., Fried, A. I., & Wientroub, S. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10620 · Cited by 16 · see citing works

A high cholesterol diet elevates hippocampal cytokine expression in an age and estrogen-dependent manner in female rats

Lewis, D. K., Bake, S., Thomas, K. T., Jezierski, M. K., & Sohrabji, F. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.03.024 · Cited by 15 · see citing works

Ovariectomy does not induce osteopenia through interleukin-6 in rhesus monkeys (Macaca mulatta)

Keller, E. T., Binkley, N., Stebler, B. A., Hall, D. M., Johnston, G., Zhang, J., & Ershler, W. B. (2000) · Bone · doi:10.1016/s8756-3282(99)00240-9 · Cited by 15 · see citing works

Effect of oviductus ranae and oviductus ranae eggs on bone metabolism and osteoporosis

Wang, D., Wu, W. D., Tian, J., et al. (2012) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-012-1220-x · Cited by 15 · see citing works

Mesenchymal stem cells as the near future of cardiology medicine - truth or wish?

Brychtová, M., Thiele, J.-A., Lysák, D., Holubová, M., Králíčková, M., & Vištějnová, L. (2018) · Biomedical Papers · doi:10.5507/bp.2018.071 · Cited by 14 · see citing works

Differential Effects of E and Droloxifene on C-Reactive Protein and Other Markers of Inflammation in Healthy Postmenopausal Women

Herrington, D. M., Brosnihan, K. B., Pusser, B. E., Seely, E. W., Ridker, P. M., Rifai, N., & MacLean, D. B. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7799 · Cited by 80 · see citing works

Effects of Osteoporotic Cytokines in Ovary-Intact and Ovariectomised Rats with Induced Hyperthyroidism; Is Skeletal Responsiveness to Thyroid Hormone Altered in Estrogen Deficiency?

Şimşek, G., Uzun, H., Karter, Y., et al. (2003) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.201.81 · Cited by 10 · see citing works

The role of nitric oxide on bone metabolism in ovariectomized rats following chronic ethanol intake

Şimşek, G., Uzun, H., Aydın, S., et al. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.09.034 · Cited by 9 · see citing works

Long‐term effects of hormone replacement therapy on hepatocellular carcinoma risk and overall survival rate in women with chronic hepatitis C: A population‐based cohort study in Taiwan

Chang, K., Mo, L., Wang, C., Hsieh, C., Hsu, H., Tseng, Y., & Tseng, Y. (2020) · Advances in digestive medicine · doi:10.1002/aid2.13250 · Cited by 7 · see citing works

Efficacy of chitinase-3-like protein 1 as an in vivo bone formation predictable marker of maxillary/mandibular bone marrow stromal cells

Komabashiri, N., Suehiro, F., Ishii, M., & Nishimura, M. (2021) · Regenerative Therapy · doi:10.1016/j.reth.2021.03.004 · Cited by 7 · see citing works

The gero-inflammatory manifold

Finch, C. E., & Longo, V. D. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8350-4_13 · Cited by 9 · see citing works

Chromatin Condensation Delays Senescence in Human Mesenchymal Stem Cells by Safeguarding Nuclear Damages during In Vitro Expansion

Joshi, R., Suryawanshi, T. Y., Mukherjee, S., Shukla, S., & Majumder, A. (2024) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1155/2024/1543849 · Cited by 6 · see citing works

Cellular and Molecular Mechanisms of Postmenopausal Osteoporosis

Manolagas, S. C. (2000) · Springer eBooks · doi:10.1007/978-0-387-21628-7_13 · Cited by 6 · see citing works

Analysis of mesenchymal cells derived from an chondrodysplasia punctuate patient and donors

Shur, I., Reish, O., Ezra, E., & Benayahu, D. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20089 · Cited by 5 · see citing works

Genotoxicity of cytokines at chemotherapy-induced ‘storm’ concentrations in a model of the human bone marrow

Asurappulige, H. S. H., Thomas, A. D., & Morse, H. (2023) · Mutagenesis · doi:10.1093/mutage/gead018 · Cited by 5 · see citing works

Metabolic Bone Disease

Lane, N. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-31696-5.00101-7 · Cited by 4 · see citing works

Selenium and Mammalian Uterine Health: A Comprehensive Review

Wu, R.-N., Li, X., Li, Z.-M., Luo, J., Zhang, Z.-W., & Guo, M.-Y. (2025) · Biology · doi:10.3390/biology14091295 · Cited by 4 · see citing works

The Effects of Contraceptive Pills on Oral Health: A Review Study

Al–Saffar, M. T. (2019) · Acta Scientific Dental Scienecs · doi:10.31080/asds.2019.03.0700 · Cited by 3 · see citing works

Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in insulin resistant c57bl/6 mice and in vitro studies.Preprint

Cugno, C., Kizhakayil, D., Calzone, R., Rahman, S. M., Halade, G. V., & Rahman, M. T. (2020) · Research Square · doi:10.21203/rs.3.rs-126494/v1 · Cited by 3 · see citing works

Immune System

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Osteoblast Biology

Lian, J. B., & Stein, G. S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375098-3.50007-x · Cited by 2 · see citing works

Regulation of Bone Cell Function by Estrogens

Komm, B. S., Cheskis, B. J., & Bodine, P. V. N. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375098-3.50015-9 · Cited by 2 · see citing works

Inferred Functions of "Novel" Genes Identified in Fibroblasts Chondroinduced by Demineralized Bone

Yates, K. E. (2004) · DNA and Cell Biology · doi:10.1089/104454904322745899 · Cited by 2 · see citing works

Aging Mesenchymal Stem Cells in Lung Disease

Kapetanaki, M. G., Mora, A. L., & Rojas, M. M. (2014) · Wiley eBooks · doi:10.1002/9781118396292.ch12 · Cited by 1 · see citing works

A influência de contraceptivos orais combinados na condição periodontal

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Haematopoietic stem cells and the thymus in aging

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ASSOCIAÇÃO DA TERAPIA DE REPOSIÇÃO HORMONAL COM A CONDIÇÃO PERIODONTAL DE MULHERES

Tavares, R. D. C. R., Reckziegel, M. L., Ortigara, G. B., Tatsch, K. F., Sfreddo, C. S., & Moreira, C. H. C. (2021) · Saúde (Santa Maria) · doi:10.5902/2236583463087

Faculty Opinions recommendation of Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model.

Mobasheri, A. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718267258.793490814

Chromatin condensation delays human mesenchymal stem cells senescence by safeguarding nuclear damages during long term in vitro expansionPreprint

Joshi, R., Suryawanshi, T. Y., Mukherjee, S., Shukla, S., & Majumder, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.22.537784

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

에스트로겐/칼슘 혼합요법이 난소절제 쥐의 골대사에 미치는 영향 II. 칼슘, 인 및 질소대사에 관한 연구

이경화, & 오승호 (1996) · Journal of the Korean Society of Food Science and Nutrition

How and when are substrates selected for type III secretion?

Aldridge, P. D. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(01)02014-5 · Cited by 58 · see citing works

Y ersinia Ysc ‐ Yop type III secretion feedback inhibition is relieved through YscV ‐dependent recognition and secretion of LcrQ

Li, Y., Li, L., Huang, L., et al. (2013) · Molecular Microbiology · doi:10.1111/mmi.12474 · Cited by 20 · see citing works

ExoS Controls the Cell Contact-Mediated Switch to Effector Secretion in Pseudomonas aeruginosa

Cisz, M., Lee, P., & Rietsch, A. (2007) · Journal of Bacteriology · doi:10.1128/jb.01553-07 · Cited by 76 · see citing works