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Identification of a Potent Phytoestrogen in Hops (Humulus lupulus L.) and Beer
Open accessAbstract
The female flowers of the hop plant are used as a preservative and as a flavoring agent in beer. However, a recurring suggestion has been that hops have a powerful estrogenic activity and that beer may also be estrogenic. In this study, sensitive and specific in vitro bioassays for estrogens were used for an activity-guided fractionation of hops via selective solvent extraction and appropriate HPLC separation. We have identified a potent phytoestrogen in hops, 8-prenylnaringenin, which has an activity greater than other established plant estrogens. The estrogenic activity of this compound was reflected in its relative binding affinity to estrogen receptors from rat uteri. The presence of 8-prenylnaringenin in hops may provide an explanation for the accounts of menstrual disturbances in female hop workers. This phytoestrogen can also be detected in beer, but the levels are low and should not pose any cause for concern.
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Citations
Cited by
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Stevens, J. F., & Page, J. E. (2004) · Phytochemistry · doi:10.1016/j.phytochem.2004.04.025 · Cited by 673
Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450
Hodek, P., Trefil, P., & Stiborová, M. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(01)00285-x · Cited by 649
Beer constituents as potential cancer chemopreventive agents
Gerhäuser, C. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.04.012 · Cited by 408
Cortés‐Martín, A., Selma, M. V., Tomás‐Barberán, F. A., González‐Sarrías, A., & Espín, J. C. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900952 · Cited by 298
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Darbre, P. (2018) · International Journal of General Medicine · doi:10.2147/ijgm.s102230 · Cited by 248
Metadata
- Authors
- Milligan, S. R., Kalita, J. C., Heyerick, A., Rong, H., Cooman, L. D., & Keukeleire, D. D.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- Oxford University Press
- Published
- 1999-06-01
- Volume
- 84
- Issue
- 6
- Pages
- 2249-2249
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2125400249
- Cited by
- 375
- References
- 0
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Milligan, S. R., Kalita, J. C., Heyerick, A., Rong, H., Cooman, L. D., & Keukeleire, D. D. (1999). Identification of a Potent Phytoestrogen in Hops (Humulus lupulus L.) and Beer. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.84.6.2249
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
