The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes
Open accessAbstract
The full consensus on the role of dietary polyphenols as human‐health‐promoting compounds remains elusive. The two‐way interaction between polyphenols and gut microbiota (GM) (i.e., modulation of GM by polyphenols and their catabolism by the GM) is determinant in polyphenols’ effects. The identification of human metabotypes associated with a differential gut microbial metabolism of polyphenols has opened new research scenarios to explain the inter‐individual variability upon polyphenols consumption. The metabotypes unequivocally identified so far are those involved in the metabolism of isoflavones (equol and(or) O‐desmethylangolesin producers versus non‐producers) and ellagic acid (urolithin metabotypes, including producers of only urolithin‐A (UM‐A), producers of urolithin‐A, isourolithin‐A, and urolithin‐B (UM‐B), and non‐producers (UM‐0)). In addition, the microbial metabolites (phenolic‐derived postbiotics) such as equol, urolithins, valerolactones, enterolactone, and enterodiol, and 8‐prenylnaringenin, among others, can exert differential health effects. The knowledge is updated and position is taken here on i) the two‐way interaction between GM and polyphenols, ii) the evidence between phenolic‐derived postbiotics and health, iii) the role of metabotypes as biomarkers of GM and the clustering of individuals depending on their metabotypes (metabotyping) to explain polyphenols’ effects, and iv) the gut microbial metabolism of catecholamines to illustrate the intersection between personalized nutrition and precision medicine.
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Cites
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Nataraj, B. H., Ali, S. A., Behare, P. V., & Yadav, H. (2020) · Microbial Cell Factories · doi:10.1186/s12934-020-01426-w · Cited by 737
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Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further
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Impact of the natural compound urolithin a on health, disease, and aging
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Metadata
- Authors
- Cortés‐Martín, A., Selma, M. V., Tomás‐Barberán, F. A., González‐Sarrías, A., & Espín, J. C.
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2020-04-09
- Volume
- 64
- Issue
- 9
- Pages
- e1900952-e1900952
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W3010924948
- Cited by
- 298
- References
- 180
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Cortés‐Martín, A., Selma, M. V., Tomás‐Barberán, F. A., González‐Sarrías, A., & Espín, J. C. (2020). Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes. Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.201900952
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
