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The Primate Adrenal Zona Reticularis is Defined by Expression of Cytochrome b5, 17α-hydroxylase/17,20-lyase Cytochrome P450 (P450c17) and NADPH-Cytochrome P450 Reductase (reductase) but not 3β-Hydroxysteroid Dehydrogenase/Δ5-4 Isomerase (3β-HSD)
Abstract
Biochemical studies suggest that 17,20-lyase activity, and thus efficient synthesis of androgens by human P450c17, requires both reductase and the accessory protein cytochrome b5. Since the human and primate zona reticularis (ZR) secrete androgens, the expression of these proteins, and of 3β-HSD, was investigated by immunocytochemistry in the adrenal cortex of the mature rhesus macaque. Cytochrome b5 expression was restricted to the cells of the ZR which appeared deficient in 3β-HSD. However, both P450c17 and reductase were evident throughout the zona fasciculata. These data provide essential evidence in support of a functional role for cytochrome b5 in the regional control of 17α-hydroxylase and 17,20-lyase activities of P450c17 and thereby adrenal C19 steroid secretion by the primate adrenal gland.
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“The abundance of 3HSD protein in the zona reticularis appears to decrease with the onset of adrenarche (202,724,725), and the adrenal expression of cytochrome b 5 , which fosters the 17,20-lyase activity of P450c17, is almost exclusively confined to the zona reticularis (203, 205, 726); both of these factors strongly favor the production of DHEA (727).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [203]
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The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458
Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family
Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0050 · Cited by 620
Minireview: Regulation of Steroidogenesis by Electron Transfer
Miller, W. L. (2005) · Endocrinology · doi:10.1210/en.2005-0096 · Cited by 324
Adrenarche—physiology, biochemistry and human disease
Auchus, R. J., & Rainey, W. E. (2004) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01858.x · Cited by 296
Dissecting human adrenal androgen production
Rainey, W. E., Carr, B. R., Sasano, H., Suzuki, T., & Mason, J. I. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(02)00609-4 · Cited by 268
Metadata
- Authors
- Mapes, S., Corbin, C. J., Tarantal, A., & Conley, A.
- Affiliations
- University of California, Davis (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1999-09-01
- Volume
- 84
- Issue
- 9
- Pages
- 3382-3385
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2001855049
- Cited by
- 86
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Keywords
- adrenal zona reticularis, cytochrome b5, P450c17, 17,20-lyase, NADPH-cytochrome P450 reductase, 3β-hydroxysteroid dehydrogenase, androgen production, rhesus monkeys, adrenal cortex, zona fasciculata, steroidogenic enzyme expression
- MeSH terms
- Animals, Humans, Immunohistochemistry, Macaca mulatta, Male, Multienzyme Complexes, NADPH-Ferrihemoprotein Reductase, Progesterone Reductase, Steroid Isomerases, Steroid 17-alpha-Hydroxylase, Zona Reticularis, Cytochromes b5
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- This page
- CoChat. (2026). Citation check: The Primate Adrenal Zona Reticularis is Defined by Expression of Cytochrome b5, 17α-hydroxylase/17,20-lyase Cytochrome P450 (P450c17) and NADPH-Cytochrome P450 Reductase (reductase) but not 3β-Hydroxysteroid Dehydrogenase/Δ5-4 Isomerase (3β-HSD). https://app.cochat.ai/papers/10.1210/jcem.84.9.6105
- The paper
- Mapes, S., Corbin, C. J., Tarantal, A., & Conley, A. (1999). The Primate Adrenal Zona Reticularis is Defined by Expression of Cytochrome b5, 17α-hydroxylase/17,20-lyase Cytochrome P450 (P450c17) and NADPH-Cytochrome P450 Reductase (reductase) but not 3β-Hydroxysteroid Dehydrogenase/Δ5-4 Isomerase (3β-HSD). The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.84.9.6105
