The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Is Neuropsychological Development Related to Maternal Hypothyroidism or to Maternal Hypothyroxinemia?
Abstract
Several recent publications have drawn attention to the role of the thyroid hormone status of the mother on the future neuropsychological development of the child.The screening of pregnant women for clinical or subclinical hypothyroidism based on second trimester elevated maternal TSH values has been proposed.Here, we have summarized present epidemiological and experimental evidence strongly suggesting that conditions resulting in first trimester hypothyroxinemia (a low for gestational age circulating maternal free T 4 , whether or not TSH is increased) pose an increased risk for poor neuropsychological development of the fetus.This would be a consequence of decreased availability of maternal T 4 to the developing brain, its only source of thyroid hormone during the first trimester; T 4 is the required substrate for the ontogenically regulated generation of T 3 in the amounts needed for optimal development in different brain structures, both temporally and spatially.Normal maternal T 3
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Citations
Cites
Glinoer, D. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0300 · Cited by 1,364
Cited by
Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber, K. A. (2012) · Endocrine Practice · doi:10.4158/ep12280.gl · Cited by 1,567
The Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418
Thyroid Function and Human Reproductive Health
Krassas, G. E., Poppe, K., & Glinoer, D. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0041 · Cited by 1,223
Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber for the American Association, K. A. (2012) · Thyroid · doi:10.1089/thy.2012.0205 · Cited by 1,053
Overt and Subclinical Hypothyroidism Complicating Pregnancy
Abalovich, M., Gutierrez, S., Alcaraz, G., Maccallini, G., Garcia, A., & Levalle, O. (2002) · Thyroid · doi:10.1089/105072502753451986 · Cited by 714
Metadata
- Authors
- Morreale de Escobar, G.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2000-11-01
- Volume
- 85
- Issue
- 11
- Pages
- 3975-3987
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W4245627020
- Cited by
- 437
- References
- 1
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Morreale de Escobar, G. (2000). Is Neuropsychological Development Related to Maternal Hypothyroidism or to Maternal Hypothyroxinemia? Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.85.11.3975
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
