The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Menstrual Cycle Effects on the Neurohumoral and Autonomic Nervous Systems Regulating the Cardiovascular System
Open accessAbstract
Gonadal hormones may affect homeostatic mechanisms regulating the cardiovascular system. We investigated this relationship at five different crucial hormonal time points along the menstrual cycle. Eight eumenorrheic healthy subjects underwent a battery of autonomic tests, hemodynamics, and volume-regulatory hormone measurements. Fluid-regulatory hormones, plasma renin activity, and aldosterone increased along the luteal phase (P = 0.003 and 0.02, respectively), whereas rest supine-corrected hematocrit declined in the course of the menstrual cycle (P = 0.001). Plasma norepinephrine decreased from 1.4 +/- 0.2 to 0.95 +/- 0.1 nmol/liter (P < 0.02) [early follicular (EF) to late follicular]. Thereafter, concentrations gradually returned to EF levels. Lf to Hf domain ratio (spectral analysis of electrocardiogram) showed a difference from that of norepinephrine. The cardiovagal baroreflex sensitivity increased significantly along the luteal phase (P = 0.04). The dose of isoproterenol required to increase heart rate (HR) 15 beats per minute was 0.19 +/- 0.04 microg during the EF time point, and it increased to 0.39 +/- 0.06 microg during the late luteal time point (P = 0.05). However, blood pressure, HR, and their responses to orthostatic stress remained unchanged. Fluctuations in the ovarian hormones along the menstrual cycle are associated with unchanged blood pressure and HR, despite the significant variations in the different homeostatic mechanisms regulating the cardiovascular system.
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Cites
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The neuropathic postural tachycardia syndrome
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Self-citationPlasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans.
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Self-citationEffect of standing on neurohumoral responses and plasma volume in healthy subjects
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Cited by
Postural Orthostatic Tachycardia Syndrome
Bryarly, M., Phillips, L. T., Fu, Q., Vernino, S., & Levine, B. D. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.11.059 · Cited by 245
Chronic orthostatic intolerance and the postural tachycardia syndrome (POTS)
Stewart, J. M. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.06.084 · Cited by 116
Relationship between Aldosterone and Progesterone in the Human Menstrual Cycle
Szmuilowicz, E. D., Adler, G. K., Williams, J. S., Green, D. E., Yao, T. M., Hopkins, P. N., & Seely, E. W. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1154 · Cited by 107
Ovarian Cycle and Sympathoexcitation in Premenopausal Women
Carter, J. R., Fu, Q., Minson, C. T., & Joyner, M. J. (2013) · Hypertension · doi:10.1161/hypertensionaha.112.202598 · Cited by 105
The Postural Tachycardia Syndrome
Medow, M. S., & Stewart, J. M. (2007) · Cardiology in Review · doi:10.1097/01.crd.0000233768.68421.40 · Cited by 105
Metadata
- Authors
- Hirshoren, N.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2002-04-01
- Volume
- 87
- Issue
- 4
- Pages
- 1569-1575
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2163884745
- Cited by
- 165
- References
- 9
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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