The DOI matches its Crossref record.
Low Dose Leptin Administration Reverses Effects of Sustained Weight-Reduction on Energy Expenditure and Circulating Concentrations of Thyroid Hormones
Abstract
Maintenance of a reduced body weight is associated with decreased 24-hour energy expenditure, and decreased circulating concentrations of leptin and thyroid hormones. To determine whether these adaptive metabolic and endocrine changes are partly leptin-mediated, we measured body composition, aspects of energy expenditure, and circulating concentrations of leptin and thyroid hormones in 4 subjects at 3 time points: 1.) Usual body weight; 2.) While stable at 10% reduced body weight; and 3.) During a 5-week period at 10% reduced body weight while receiving twice per day leptin injections that restored 8 AM circulating leptin concentrations to those seen at usual body weight. During maintenance of a 10% reduced body weight, circulating T3, T4, and leptin concentrations were decreased. All of these endocrine changes were reversed by administration of “replacement” doses of leptin (r-metHuLeptin). Indirect calorimetry, and subtle changes in body composition associated with leptin administration, were used to calculate the net change in stored calories and in 24-hour energy expenditure. Total energy expenditure increased in all subjects during r-metHuLeptin administration. These data indicate that decrease leptin concentrations resulting from loss of fat mass account for some aspects of the endocrine/metabolic phenotype associated with the weight-reduced state.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although r-metHuLeptin administration has been found to increase FT4 and FT3 levels in leptin-deficient children (34) and to reverse the decreased T3 and T4 levels in four subjects on a long-term hypocaloric diet (42)”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [42]
Citations
Cited by
Sorted by citations
Items 101–127 of 127
Conroy, R., Febres, G., McMahon, D. J., Thorner, M. O., Gaylinn, B. D., Conwell, I. M., Aronne, L. J., & Körner, J. (2014) · International Journal of Endocrinology · doi:10.1155/2014/120286 · Cited by 6
The Neuroendocrine Control of Energy Balance
Lustig, R. H. (2010) · Springer eBooks · doi:10.1007/978-1-60327-874-4_2 · Cited by 6
Gene environment Interactions and the Origin of the Modern Obesity Epidemic
Speakman, J. R. (2007) · Elsevier eBooks · doi:10.1016/b978-012370633-1/50012-8 · Cited by 4
Aspectos atuais da regulação do peso corporal: ação da leptina no desequilíbrio energético
Donato, J., Pedrosa, R. G., & Tirapegui, J. (2004) · Revista Brasileira De Ciencias Farmaceuticas · doi:10.1590/s1516-93322004000300003 · Cited by 3
Lustig, R. H. (2010) · Endocrine updates · doi:10.1007/978-1-4419-7034-3_1 · Cited by 2
Redman, L. M., & Ravussin, É. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-400-1_8 · Cited by 2
The role of uncoupling protein 3 in human physiology
Garvey, W. T. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317835 · Cited by 2
Leptin and Other Endocrine Systems
Considine, R. V. (2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_6 · Cited by 2
Sun, X., Yin, Y., Song, M., Droz, B. A., LIN, Y., Beaty, K. N., Zhou, B., Roh, H. C., Wilson, J. M., Cain, P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.18.695152 · Cited by 2
Neuroendocrine and Metabolic Adaptations in the Central Nervous System That Facilitate Weight Regain
Lechan, R. M., & Fekete, C. (2010) · Springer eBooks · doi:10.1007/978-1-60327-874-4_28 · Cited by 1
How humans economize: energy restriction and end energy expenditure
Camps, S. G. (2015) · doi:10.26481/dis.20150416sc · Cited by 1
Gene analysis for studying the process of weight regain after weight loss
Roumans (2017) · Research Publications (Maastricht University) · doi:10.26481/dis.20170623nr · Cited by 1
Aziz, A. A., & Anderson, G. H. (2005) · CRC Press eBooks · doi:10.1201/9781420038255.ch16 · Cited by 1
Blundell, J. E., Finlayson, G., & Halford, J. C. G. (2009) · Clinical Obesity in Adults and Children · doi:10.1002/9781444307627.ch11 · Cited by 1
Ahima, R. S. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_19
Genetic Disorders Involving Leptin and the Leptin Receptor
Farooqi, I. S. (2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_15
Serum Leptin levels in Obese Post MenopauseWomen
Ghaith, A.-Z. A., & Khazraj, F. A. (2009) · Al Mustansiriyah Journal of Pharmaceutical Sciences · doi:10.32947/ajps.v6i1.370
Dietary polyphenols: modulators of energy and substrate metabolism in obese humans
Most, J. (2016) · Research Publications (Maastricht University) · doi:10.26481/dis.20160115jm
A importância da ação do hormônio do crescimento sobre os neurônios NPY/AgPR do hipotálamo.
Couto, G. C. L. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2019.tde-17062019-165021
Ben‐Ezra, V. (2005) · CRC Press eBooks · doi:10.1201/9781420038422.ch8
(2011) · CRC Press eBooks · doi:10.1201/b10790-15
(2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.89.11.9996
Molecular Physiology of Monogenic and Syndromic Obesities in Humans
Chung, W. K., & Leibel, R. L. (2007) · Humana Press eBooks · doi:10.1007/978-1-60327-139-4_1
Self-citation
Metadata
- Authors
- Rosenbaum, M., Murphy, E. M., Heymsfield, S. B., Matthews, D. E., & Leibel, R. L.
- Affiliations
- Columbia University (US)
- University of Vermont Medical Center (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2002-05-01
- Volume
- 87
- Issue
- 5
- Pages
- 2391-2394
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2044939881
- Cited by
- 407
- References
- 0
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 6 · 2019: 10 · 2018: 16 · 2017: 25 · 2016: 11 · 2015: 22 · 2014: 19 · 2013: 13 · 2012: 13
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk030583-18)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064773, DK-30583)
- National Center for Research Resources (RR 00645, M01RR000645)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, leptin replacement, weight loss, energy expenditure, thyroid hormones, T3, thyroxine, body composition, fat mass, metabolic adaptation, obesity, leptin deficiency
- MeSH terms
- Adult, Body Composition, Calorimetry, Indirect, Dose-Response Relationship, Drug, Energy Metabolism, Female, Humans, Male, Osmolar Concentration, Thyroid Hormones, Weight Loss, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
