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Increased Resistin Gene and Protein Expression in Human Abdominal Adipose Tissue
Open accessAbstract
Resistin, a novel signalling molecule isolated in mice has been suggested to be the putative hormone thought to link obesity with type 2 diabetes. The aim of this study was to examine resistin protein expression in human adipose tissue depots and resistin secretion in isolated adipose cells, to characterize resistin expression in human adipose tissue. Both resistin mRNA and protein expression were analysed from human adipose tissue (n = 5 adipose tissue samples: abdominal subcutaneous (Sc) n = 19, abdominal omental adipose tissue (Om) n = 10, thigh n = 9, breast n = 7). Resistin protein expression levels were similar in both the abdominal Sc and Om adipose tissue depots, and expression in abdominal fat depots were increased compared with thigh (p < 0.001) and breast tissue depots (p < 0.001). These findings were consistent with the mRNA expression studies. Resistin was secreted from both pre-adipocytes and adipocytes cells. Thus, resistin resides within isolated adipose cells and is expressed and secreted in human adipose tissue. In conclusion, this study confirms the expression of resistin in human adipose tissue and increased expression in abdominal fat, this suggests a potential role in linking central obesity to type 2 diabetes and/or cardiovascular disease.
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Cited by
Jung, U., & Choi, M.-S. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15046184 · Cited by 1,880
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
State of the art paper Biochemistry of adipose tissue: an endocrine organ
Coelho, M., Oliveira, T., & Fernandes, R. (2013) · Archives of Medical Science · doi:10.5114/aoms.2013.33181 · Cited by 1,110
Bays, H., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030723 · Cited by 664
Baker, A. R., da Silva, N. F., Quinn, D. W., Harte, A. L., Pagano, D., Bonser, R. S., Kumar, S., & McTernan, P. G. (2006) · Cardiovascular Diabetology · doi:10.1186/1475-2840-5-1 · Cited by 649
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Metadata
- Authors
- McTernan, P. G., McTernan, C. L., Chetty, R., Jenner, K., Fisher, F. M., Lauer, M. N., Crocker, J., Barnett, A. H., & Kumar, S.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- Oxford University Press
- Published
- 2002-05-01
- Volume
- 87
- Issue
- 5
- Pages
- 2407-2407
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2160490100
- Cited by
- 350
- References
- 0
- FWCI
- 24.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- McTernan, P. G., McTernan, C. L., Chetty, R., Jenner, K., Fisher, F. M., Lauer, M. N., Crocker, J., Barnett, A. H., & Kumar, S. (2002). Increased Resistin Gene and Protein Expression in Human Abdominal Adipose Tissue. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.87.5.2407
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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