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Cited by 1,880

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease

Open access
Jung, Un, Choi, Myung-Sook·2014·International Journal of Molecular Sciences
DOI 10.3390/ijms15046184
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Abstract

Accumulating evidence indicates that obesity is closely associated with an increased risk of metabolic diseases such as insulin resistance, type 2 diabetes, dyslipidemia and nonalcoholic fatty liver disease. Obesity results from an imbalance between food intake and energy expenditure, which leads to an excessive accumulation of adipose tissue. Adipose tissue is now recognized not only as a main site of storage of excess energy derived from food intake but also as an endocrine organ. The expansion of adipose tissue produces a number of bioactive substances, known as adipocytokines or adipokines, which trigger chronic low-grade inflammation and interact with a range of processes in many different organs. Although the precise mechanisms are still unclear, dysregulated production or secretion of these adipokines caused by excess adipose tissue and adipose tissue dysfunction can contribute to the development of obesity-related metabolic diseases. In this review, we focus on the role of several adipokines associated with obesity and the potential impact on obesity-related metabolic diseases. Multiple lines evidence provides valuable insights into the roles of adipokines in the development of obesity and its metabolic complications. Further research is still required to fully understand the mechanisms underlying the metabolic actions of a few newly identified adipokines.

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Crossref · 10.3390/ijms15046184

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Metadata

Authors
Jung, U., & Choi, M.-S.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2014-04-11
Volume
15
Issue
4
Pages
6184-6223
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms15046184
OpenAlex
W1978804351
Cited by
1,880
References
62
FWCI
80.89
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease. https://app.cochat.ai/papers/10.3390/ijms15046184
The paper
Jung, U., & Choi, M.-S. (2014). Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms15046184

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.