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CHEMICAL METHOD FOR THE DETERMINATION OF 17-HYDROXYCORTICOSTEROIDS AND 17-KETOSTEROIDS IN URINE FOLLOWING HYDROLYSIS WITH β-GLUCURONIDASE*
Abstract
METHODS for the estimation of metabolites of the adrenocortical steroids thus far published have given only partially satisfactory estimates of adrenocortical function. A method has been developed which gives reproducible determinations of 17,21-dihydroxy-20-ketones and 17-ketosteroids present in urine, either in the free form or conjugated as glucuronides. The acid hydrolysis of urinary adrenal steroid metabolites has been accomplished with varying degrees of success by a number of investigators (1–4), but there is considerable evidence suggesting loss or alteration of steroids during the hydrolytic process (5, 6). It has been shown that a large part of the adrenocortical steroids in urine are conjugated as glucuronides (7–10). In the present method hydrolysis with β-glucuronidase was employed and consistent levels of adrenocortical steroid metabolites were found after chromatography on a Florisil column.
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Citations
Cited by
Cushing's syndrome: a review of diagnostic tests.
Crapo, L. (1979) · Metabolism · doi:10.1016/0026-0495(79)90097-0 · Cited by 393
Powell, G. F., Brasel, J. A., Raiti, S., & Blizzard, R. M. (1967) · New England Journal of Medicine · doi:10.1056/nejm196706082762302 · Cited by 317
Effect of diphenylhydantoin on cortisol metabolism in man
Werk, E. E., MacGee, J., & Sholiton, L. J. (1964) · Journal of Clinical Investigation · doi:10.1172/jci105056 · Cited by 168
Adrenal Cortical Activity in Depressive Illness
CARPENTER, W. T., & BUNNEY, W. E. (1971) · American Journal of Psychiatry · doi:10.1176/ajp.128.1.31 · Cited by 166
Use of ACTH in the diagnosis of adrenal cortical insufficiency
Jenkins, D., Forsham, P. H., Laidlaw, J. C., Reddy, W. J., & Thorn, G. W. (1955) · The American Journal of Medicine · doi:10.1016/0002-9343(55)90200-x · Cited by 127
Metadata
- Authors
- GLENN, E. M., & NELSON, D. H.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1953-08
- Volume
- 13
- Issue
- 8
- Pages
- 911-921
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2082370852
- Cited by
- 245
- References
- 0
- FWCI
- 14.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: CHEMICAL METHOD FOR THE DETERMINATION OF 17-HYDROXYCORTICOSTEROIDS AND 17-KETOSTEROIDS IN URINE FOLLOWING HYDROLYSIS WITH β-GLUCURONIDASE*. https://app.cochat.ai/papers/10.1210/jcem-13-8-911
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- GLENN, E. M., & NELSON, D. H. (1953). CHEMICAL METHOD FOR THE DETERMINATION OF 17-HYDROXYCORTICOSTEROIDS AND 17-KETOSTEROIDS IN URINE FOLLOWING HYDROLYSIS WITH β-GLUCURONIDASE*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-13-8-911
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
