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Cited by 168Adrenal Hormones and DisordersStress Responses and CortisolHormonal Regulation and Hypertension

Effect of diphenylhydantoin on cortisol metabolism in man

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Werk, Emile E., MacGee, Joseph, Sholiton, Leon J.·1964·Journal of Clinical Investigation
DOI 10.1172/jci105056PMC PMC441983
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Abstract

1 Glossary of trivial names and abbreviations: diphenylhydantoin (DPH) =5,5'-diphenylhydantoin; 6-hydroxycortisol (6 -OHF) = 6a (/3), 11,/, 17a, 21 -tetrahydroxy -4 - pregnene-3,20 -dione; 17-OHCS = 17-hydroxycorticosteroids; ACTH = adrenocorticotrophic hormone; methopyrapone (Metopirone, Ciba Pharmaceutical Co., Summit, N. J.) =2-methyl-1,2-di-(3-pyridyl)-1-propanone.Tet- rahydro derivatives: THF (tetrahydrocortisol) = 3a,11,, 17a,21-tetrahydroxy-5/8-pregnan-20-one; allo-THF (allo- tetrahydrocortisol) = 3a,11/3,17a,21-tetrahydroxy-5a-?pregnan-20-one;THE (tetrahydrocortisone) = 3a,17a,21-tri- hydroxy-5p-pregnan-11,20-dione.Cortol = 3a,11,8,17a,20a (/3),21-pentahydroxy-5/3-pregnane; cortolone = 3a,17a,20a (/3) ,21-tetrahydroxy-5/8-pregnan-11-one; 17-KS = 17-ke- tosteroids; 1 1-hydroxyetiocholanolone = 3a,1j1/-dihydroxy-5,B-androstan-17-one; dehydroisoandrosterone = 3/3-hy- droxy-5-androstene-17-one

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  • Combined estrogen and progesterone may decrease lamotrigine levels.

    “Combined estrogen and progesterone may decrease lamotrigine levels (276), and endogenous and exogenous sex steroids may affect seizure activity and epilepsy in women ( 277).”

    From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [276]

    The Results and Discussion examine how diphenylhydantoin affects cortisol metabolism, not how combined estrogen and progesterone affect lamotrigine levels. Searches for lamotrigine and for combined sex-hormone effects found no passage addressing the attributed claim; the indexed passages provide no page number. (LLM, conf=0.78)

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Research works printed but not linked: 6

  1. [1]1. Werk, E. E., Jr., L. J. Sholiton, J. MacGee, and R. T. Marnell. Altered cortisol metabolism in ad- vanced cancer. Clin. Res. 1962, 10, 300.
  2. [2]2. Woodbury, D. M., P. S. Timiras, and A. Vernadakis. Influence of adrenocortical steroids on brain func- tion and metabolism in Hormones, Brain Function, and Behavior, H. Hoagland, Ed. New York, Academic Press, 1957, p. 27.
  3. [17]17. Kittinger, G. W. The determination of adrenal cor- tical a-ketolic steroids by quantitative paper chro- matography. J. Lab. clin. Med. 1960, 55, 796.
  4. [27]27. Borkowski, A. J., P. A. Marks, F. H. Katz, M. M. Lipman, and N. P. Christy. An abnormal pathway of steroid metabolism in patients with glucose-6- phosphate dehydrogenase deficiency. J. clin. In- vest. 1962, 41, 1346.
  5. [28]28. Yates, F. E., A. L. Herbst, and J. Urquhart. Sex difference in rate of ring A reduction of A'-3-keto- steroids in vitro by rat liver. Endocrinology 1958, 63, 887.
  6. [36]36. Clinicopathologic Conference, Washington University School of Medicine. Cushing's syndrome associ- ated with parotid gland tumor. Amer. J. Med. 1963, 34, 394.

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Authors
Werk, E. E., MacGee, J., & Sholiton, L. J.
Affiliations
Cincinnati VA Medical Center (US)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1964-09-01
Volume
43
Issue
9
Pages
1824-1835
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci105056
PMC
PMC441983
OpenAlex
W2114794397
Semantic Scholar
2e860fc4abd5ddf725205860a0b35f2f3aab4293
Cited by
168
References
36
Citations by year
2024: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 1
FWCI
8.41
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
phenytoin, cortisol metabolism, tetrahydrocortisol, tetrahydrocortisone, 17-hydroxycorticosteroids, dehydroepiandrosterone, ACTH
MeSH terms
Body Fluids, Glucuronidase, Hydrocortisone, Metabolism, Pharmacology, Phenytoin, Urine, 17-Hydroxycorticosteroids, 17-Ketosteroids, Lipid Metabolism

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