CoChat
Sign Up
Cited by 108Hormonal and reproductive studiesAdrenal Hormones and DisordersSexual Differentiation and Disorders

The DOI matches its Crossref record.

Plasma Production Rates of Testosterone in Normal Adult Men and Women and in Patients with the Syndrome of Feminizing Testes1

SOUTHREN, A. LOUIS, TOCHIMOTO, SATORU, CARMODY, NANCY C., ISURUGI, KOICHIRO·1965·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-25-11-1441
Open this paper in CoChat — free account

Abstract

The daily plasma productionrate of testosterone was measured in normal men and women and in 2 patients with the complete form of the syndrome of feminizing testes from the product of the metabolic clearance rate of testosterone in plasma as determined following a single injection of the tritiated hormone, and the mean plasma nonisotopic concentration of the steroid. The latter values were obtained from the mean of plasma testosterone levels obtained at 9 am, 5 pm and 10 pm. A significant diurnal variation was found in the normal men but not in the normal women. The mean plasma concentration of testosterone in these subjects was 0.52 and 0.06 μg/100 ml, respectively. The metabolic clearance rates in the normal men (1670–2084 I/day) were approximately twice those obtained in normal female subjects (708–759 I/day). The difference appeared to be due primarily to a larger inner pool volume (V,) (Vs where K2 = 0) in the males. The plasma production rates of testosterone were 10.8, 6.8, 10.0 and 6.7 mg/day in males and 0.49, 0.49 and 0.44 mg/day in normal females. The male values compared reasonably well with those reported for the urinary testosterone glucuronoside method. However, in the female the daily plasma production rates of testosterone were considerably less than those obtained by the urinary metabolite technique. This suggests that in women, in contrast to men, a significantly greater proportion of total testosterone is synthesized from precursors in a separate anatomical compartment and conjugated before entering the circulation. Thus, the error involved in the measurement of testosterone production by the urinary metabolite method is considerably greater in women than in men. In the subjects with the syndrome of feminizing testes the inner pool volume (Vi) and the total volume of distribution (V1+V2) were similar to those observed in the normal adult females. The metabolic clearance rates of testosterone were 954 and 1072 I/day and this gave calculated plasma production rates of the steroid of 6.5 and 9.6 μg/day. The presence of normal adult male production rates of testosterone provides additional evidence in favor of the view that the manifestations of the syndrome are related to a defect in androgen action.

Overview

Integrity signals

Registry

Crossref · 10.1210/jcem-25-11-1441

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cited by

Sorted by citations

Related

See all

Metadata

Authors
SOUTHREN, A. L., TOCHIMOTO, S., CARMODY, N. C., & ISURUGI, K.
Affiliations
New York Medical College (US)
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1965-11
Volume
25
Issue
11
Pages
1441-1450
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-25-11-1441
OpenAlex
W2041388451
Cited by
108
References
0
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1
FWCI
7.81
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
testosterone, metabolic clearance rate, androgen insensitivity syndrome, diurnal variation, sex differences, volume of distribution
MeSH terms
Adult, Blood, Female, Humans, Male, Disorders of Sex Development, Testis, Testosterone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review