Elevation of certain plasma proteins in man following estrogen administration: a dose-response relationship
Abstract
The degree of elevation of the plasma concentrations of corticosteroid-binding globulin (CBG), β-glucuronidase and ceruloplasmin in response to estrogen administration was shown to be related, within limits, to the dose of estrogen. Three estrogenic materials—Premarin, diethylstilbestrol and ethinylestradiol—were tested. The highest dose-response correlation was observed with CBG and the lowest with ceruloplasmin. Ratios of potency for Premarin, diethylstilbestrol and ethinylestradiol were found to be 1:13–15:100–400, respectively. Women were found to show a significantly greater CBG rise than men after 7 days of 5 mg of diethylstilbestrol. The maximal rise of plasma CBG was found after 14 days of 5 mg of diethylstilbestrol daily. The response in 7 days was 67% of maximum.
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As the estrogen dose varies between different COC formulations, a common cutoff could be unreliable due to a different degree of CBG induction.
“However, as the estrogen dose varies between different COC formulations, a common cutoff could be unreliable due to a different degree of CBG induction (6).”
From Salivary Cortisol and Cortisone Can Circumvent Confounding Effects of Oral Contraceptives in the Short Synacthen Test (2024) · cites this paper as [6]
An increased amount of corticosteroid-binding globulin entails a risk for misleadingly normal total plasma cortisol levels.
“However, an increased amount of corticosteroid-binding globulin (CBG) entails a risk for misleadingly normal total plasma cortisol levels as more CBG-bound cortisol will be measured, even though cortisol release and free, biologically active cortisol levels may be low (5-9).”
From Salivary Cortisol and Cortisone Can Circumvent Confounding Effects of Oral Contraceptives in the Short Synacthen Test (2024) · cites this paper as [6]
CBG induction is dependent on the estrogen dose and not influenced by the synthetic progestin component of the COC.
“CBG induction has been reported to be dependent on the estrogen dose and not to be influenced by the synthetic progestin component of the COC (6, 18).”
From Salivary Cortisol and Cortisone Can Circumvent Confounding Effects of Oral Contraceptives in the Short Synacthen Test (2024) · cites this paper as [6]
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Guinan, P., Ablin, R. J., Nourkayhan, S., et al. (1975) · Urology · doi:10.1016/0090-4295(75)90797-9
Measurement of Biomarkers for Environmental Estrogen Exposure in Raccoons
Dean-Colomb, W. M., & Jeffery, E. H. (1999) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
- Authors
- MUSA, B. U., SEAL, U. S., DOE, R. P., Lamusga, R. F., Lewis, M. D., & Glaser, R.
- Affiliations
- University of Minnesota (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1965-09
- Volume
- 25
- Issue
- 9
- Pages
- 1163-1166
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2059773854
- Cited by
- 105
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2021: 3 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 2
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- estrogen, corticosteroid-binding globulin, beta-glucuronidase, ceruloplasmin, dose-response relationship, conjugated equine estrogens, diethylstilbestrol, ethinyl estradiol, sex differences, estrogen potency
- MeSH terms
- Adult, Blood, Ceruloplasmin, Diethylstilbestrol, Estrogens, Conjugated (USP), Ethinyl Estradiol, Glucuronidase, Humans, Male, Transcortin
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