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Plasma Precursors of Estrogen. I. Extent of Conversion of Plasma Δ4-Androstenedione to Estrone in Normal Males and Nonpregnant Normal, Castrate and Adrenalectomized Females
Abstract
After the intravenous administration of tracer doses of 4-14C-Δ4-androstenedione +6,7-3H-estrone (or 6,7-3H-estradiol) to normal adult males, and normal, castrate and adrenalectomized young adult females, radioactive urinary metabolites of estrogen were isolated from 72-hr urine collections. In each subject studied a fraction of the administered 4-14C-Δ4-androstenedione was metabolized in the same manner as was the injected tritium labeled estrone. The extent of conversion of 4-14C-Δ4-androstenedione to the product hormone, estrone, was calculated from the relationship between the 3H/14C ratio of the administered tracers and that of the isolated urinary estrone. In the subjects studied an average of 1.3% of Δ4-androstenedione (range 1.0- 1-7 %) was converted to estrone. These results indicate that in the young adult female an “extraglandular” source of estrone of approximately 44 μg/day may arise from plasma borne Δ4-androstenedione. In the adult male, 18 μ of estrone /day can be expected to originate from plasma Δ4-androstenedione.
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Citations
Cited by
Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947
The Formation of Estrogens by Central Neuroendocrine Tissues
NAFTOLIN, F., RYAN, K. J., DAVIES, I. J., REDDY, V. V., FLORES, F., PETRO, Z., KUHN, M., WHITE, R. J., TAKAOKA, Y., & WOLIN, L. (1975) · Proceedings of the 1974 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571131-9.50012-8 · Cited by 793
MacDonald, P. C., Edman, C. D., Hemsell, D. L., Porter, J. C., & Siiteri, P. K. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90287-9 · Cited by 440
Self-citationAromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target
Zeitoun, K. M., & Bulun, S. E. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00393-3 · Cited by 256
Weinstein, R. L., Kelch, R. P., Jenner, M. R., Kaplan, S. L., & Grumbach, M. M. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107526 · Cited by 170
Metadata
- Authors
- MACDONALD, P. C., ROMBAUT, R. P., & SIITERI, P. K.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1967-08
- Volume
- 27
- Issue
- 8
- Pages
- 1103-1111
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1987557870
- Cited by
- 256
- References
- 0
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Plasma Precursors of Estrogen. I. Extent of Conversion of Plasma Δ4-Androstenedione to Estrone in Normal Males and Nonpregnant Normal, Castrate and Adrenalectomized Females. https://app.cochat.ai/papers/10.1210/jcem-27-8-1103
- The paper
- MACDONALD, P. C., ROMBAUT, R. P., & SIITERI, P. K. (1967). Plasma Precursors of Estrogen. I. Extent of Conversion of Plasma Δ4-Androstenedione to Estrone in Normal Males and Nonpregnant Normal, Castrate and Adrenalectomized Females. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-27-8-1103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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