Absorption of Triiodothyronine in Man
Abstract
Triiodothyronine (T3) absorption was measured in 14 studies of 8 normal subjects by a double isotope method similar to that previously employed for thyroxine (T4) absorption measurement (1). Unlike T4, T3 is almost entirely absorbed from the intestine, with a mean absorption at 4 hr of 95.4%. Also, oral T3 was absorbed equally efficiently whether given with .01 or .81 g albumin. Disappearance of the orally administered T3 from serum was faster than that of intravenous T3.
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The post-dose spike of serum T3 is the result of rapid, very efficient intestinal absorption that reaches >95% by 4 hours.
“The post-dose spike of serum T3 is the result of a rapid, very efficient intestinal absorption that reaches >95% by 4 hours (47)”
From Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism (2020) · cites this paper as [47]
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Surks, M. I., Schadlow, A. R., Stock, J. M., & Oppenheimer, J. H. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107244 · Cited by 223 · see citing works
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Aspects of the absorption of oral L-thyroxine in normal man
Wenzel, K. W., & Kirschsieper, H. E. (1977) · Metabolism · doi:10.1016/0026-0495(77)90121-4 · Cited by 151 · see citing works
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Lieblich, J., & Utiger, R. D. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106786 · Cited by 128 · see citing works
Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism
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- Authors
- HAYS, M. T.
- Affiliations
- United States Department of Veterans Affairs (US)
- Corresponding author
- HAYS, MARGUERITE T.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1970-05
- Volume
- 30
- Issue
- 5
- Pages
- 675-677
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2067276001
- Cited by
- 47
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2016: 1 · 2015: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- triiodothyronine, intestinal absorption, oral absorption, double isotope method, albumin binding
- MeSH terms
- Dialysis, Female, Humans, Intestinal Absorption, Iodine Radioisotopes, Ion Exchange Resins, Male, Serum Albumin, Triiodothyronine
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