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SYNDROME OF ANDROGEN INSENSITIVITY IN MAN: ABSENCE OF 5 α - DIHYDROTESTOSTERONE BINDING PROTEIN IN SKIN FIBROBLASTS.1
Abstract
A method has been developed for measuring specific DHT binding in cultured human skin fibroblasts. Initial studies indicate that about one half of the measured bindingis nuclear and the rest cytoplasmic. The amount of binding per cell and the dissociation constant measured in normal fibroblasts is comparable to reported values for prostatic tissue. No appreciable DHT binding was detectable in fibroblasts from androgen insensitive patients. Deficiency of DHT binding protein (s) could account for the syndrome of androgen insensitivity (testicular feminization) in man.
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Citations
Cited by
Androgen Receptor Defects: Historical, Clinical, and Molecular Perspectives*
QUIGLEY, C. A., BELLIS, A. D., MARSCHKE, K. B., EL-AWADY, M. K., WILSON, E. M., & FRENCH, F. S. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-271 · Cited by 1,447
Cloning of Human Androgen Receptor Complementary DNA and Localization to the X Chromosome
Lubahn, D. B., Joseph, D. R., Sullivan, P. M., Willard, H. F., French, F. S., & Wilson, E. M. (1988) · Science · doi:10.1126/science.3353727 · Cited by 1,016
The hormonal-control of sexual development
Wilson, J. D., George, F. W., & Griffin, J. E. (1981) · Science · doi:10.1126/science.7010602 · Cited by 451
Testosterone: A Major Determinant of Extragenital Sexual Dimorphism
Bardin, C. W., & Catterall, J. F. (1981) · Science · doi:10.1126/science.7010603 · Cited by 386
Possible role for H–Y antigen in the primary determination of sex
WACHTEL, S. S., OHNO, S., Koo, G. C., & BOYSE, E. A. (1975) · Nature · doi:10.1038/257235a0 · Cited by 356
Metadata
- Authors
- Keenan, B. S., Meyer, W. J., Hadjian, A. J., Jones, H. W., & Migeon, C. J.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1974-06
- Volume
- 38
- Issue
- 6
- Pages
- 1143-1146
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2049441749
- Cited by
- 256
- References
- 0
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: SYNDROME OF ANDROGEN INSENSITIVITY IN MAN: ABSENCE OF 5 α - DIHYDROTESTOSTERONE BINDING PROTEIN IN SKIN FIBROBLASTS.1. https://app.cochat.ai/papers/10.1210/jcem-38-6-1143
- The paper
- Keenan, B. S., Meyer, W. J., Hadjian, A. J., Jones, H. W., & Migeon, C. J. (1974). SYNDROME OF ANDROGEN INSENSITIVITY IN MAN: ABSENCE OF 5 α - DIHYDROTESTOSTERONE BINDING PROTEIN IN SKIN FIBROBLASTS.1. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-38-6-1143
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
