The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cloning of Human Androgen Receptor Complementary DNA and Localization to the X Chromosome
Abstract
The androgen receptor (AR) mediates the actions of male sex steroids. Human AR genomic DNA was cloned from a flow-sorted human X chromosome library by using a consensus nucleotide sequence from the DNA-binding domain of the family of nuclear receptors. The AR gene was localized on the human X chromosome between the centromere and q13. Cloned complementary DNA, selected with an AR-specific oligonucleotide probe, was expressed in monkey kidney (COS) cells and yielded a high-affinity androgen-binding protein with steroid-binding specificity corresponding to that of native AR. A predominant messenger RNA species of 9.6 kilobases was identified in human, rat, and mouse tissues known to contain AR and was undetectable in tissues lacking AR androgen-binding activity, including kidney and liver from androgen-insensitive mice. The deduced amino acid sequence of AR within the DNA-binding domain has highest sequence identity with the progesterone receptor.
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Cites
A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Identification of a receptor for the morphogen retinoic acid
Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965
X-linked Gene for Testicular Feminization in the Mouse
LYON, M. F., & HAWKES, S. G. (1970) · Nature · doi:10.1038/2271217a0 · Cited by 555
Absence of response to dihydrotestosterone in the syndrome of testicular feminization
STRICKLAND, A. L., & FRENCH, F. S. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-9-1284 · Cited by 50
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Cited by
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383
Androgen Receptor in Prostate Cancer
Heinlein, C. A., & Chang, C. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0032 · Cited by 1,780
Androgen Receptor (AR) Coregulators: An Overview
Heinlein, C. A., & Chang, C. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0460 · Cited by 943
Transcriptional activation and nuclear targeting signals of the human androgen receptor.
Simental, J. A., Sar, M., Lane, M. V., French, F. S., & Wilson, E. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52466-2 · Cited by 631
Self-citationIdentification of androgen receptors in normal human osteoblast-like cells.
Colvard, D. S., Eriksen, E. F., Keeting, P. E., Wilson, E. M., Lubahn, D. B., French, F. S., Riggs, B. L., & Spelsberg, T. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.3.854 · Cited by 462
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Metadata
- Authors
- Lubahn, D. B., Joseph, D. R., Sullivan, P. M., Willard, H. F., French, F. S., & Wilson, E. M.
- Venue
- Science
- Published
- 1988-04-15
- Volume
- 240
- Issue
- 4850
- Pages
- 327-330
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050602600
- Cited by
- 1,016
- References
- 4
- FWCI
- 20.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lubahn, D. B., Joseph, D. R., Sullivan, P. M., Willard, H. F., French, F. S., & Wilson, E. M. (1988). Cloning of Human Androgen Receptor Complementary DNA and Localization to the X Chromosome. Science. https://doi.org/10.1126/science.3353727
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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