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The Effect of Starvation on the Concentration and Binding of Thyroxine and Triiodothyronine in Serum and on the Response to TRH
Abstract
In 9 euthyroid obese volunteers, 4 weeks of total caloric deprivation resulted in striking decreases in both total and free triiodothyronine (T3) concentrations in serum together with a slight increase in free thyroxine (T4) concentration. These changes were not associated with alterations in the basal serum TSH concentration or in the TSH or T3 responses to exogenous TRH. It is suggested that the decrease in serum T3 concentration that occurs during starvation results from decreased peripheral conversion of T4 to T3 and may explain, at least partially, the decreased serum T3 seen in clinical states associated with inanition.
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Citations
Cited by
Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
Effect of Tri-Iodothyronine Replacement on the Metabolic and Pituitary Responses to Starvation
Gardner, D. F., Kaplan, M. M., Stanley, C. A., & Utiger, R. D. (1979) · New England Journal of Medicine · doi:10.1056/nejm197903153001102 · Cited by 239
FGF21 and the late adaptive response to starvation in humans
Fazeli, P. K., Lun, M., Kim, S. M., Bredella, M. A., Wright, S., Zhang, Y., Lee, H., Catana, C., Klibanski, A., Patwari, P., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83349 · Cited by 214
TSH and thyrotropic agonists: key actors in thyroid homeostasis
Dietrich, J. W., Landgrafe, G., & Fotiadou, E. H. (2012) · Journal of Thyroid Research · doi:10.1155/2012/351864 · Cited by 146
Kok, P., Roelfsema, F., Langendonk, J. G., Frölich, M., Burggraaf, J., Meinders, A. E., & Pijl, H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0920 · Cited by 132
Metadata
- Authors
- Portnay, G. I., O'Brian, J. T., Bush, J., Vagenakis, A. G., Azizi, F., Arky, R. A., Ingbar, S. H., & Braverman, L. E.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1974-07
- Volume
- 39
- Issue
- 1
- Pages
- 191-194
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2070069097
- Cited by
- 252
- References
- 0
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Effect of Starvation on the Concentration and Binding of Thyroxine and Triiodothyronine in Serum and on the Response to TRH. https://app.cochat.ai/papers/10.1210/jcem-39-1-191
- The paper
- Portnay, G. I., O'Brian, J. T., Bush, J., Vagenakis, A. G., Azizi, F., Arky, R. A., Ingbar, S. H., & Braverman, L. E. (1974). The Effect of Starvation on the Concentration and Binding of Thyroxine and Triiodothyronine in Serum and on the Response to TRH. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-39-1-191
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
