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Further Studies on Leydig Cell Function in Old Age
Abstract
Pathophysiological mechanisms leading to a decreased Leydig cell function in old males were studied. Increased basal plasma LH and FSH levels, an increased pituitary reaction to LHRH 200 μg iv, and a decreased responsiveness of the Leydig cells to hCG stimulation, lead to the conclusion that the decreased Leydig cell function in old age has a primary testicular origin. The plasma estrone and estradiol levels are slightly but significantly increased in elderly males, the free estradiol concentration is however unchanged. There exists a highly significant correlation between the (log transformed) apparent free testosterone concentration and LH and FSH levels suggesting that the feedback of the gonadotropin secretion is regulated via the free rather than via total testosterone levels.
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Citations
Cited by
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760
Södergard, R., Bäckström, T., Shanbhag, V., & Carstensen, H. (1982) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(82)90038-3 · Cited by 1,080
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Kaufman, J. M., & Vermeulen, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0013 · Cited by 1,079
Self-citationAndropause: clinical implications of the decline in serum testosterone levels with aging in men
Matsumoto, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.m76 · Cited by 490
HARMAN, S. M., & TSITOURAS, P. D. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-1-35 · Cited by 370
Metadata
- Authors
- RUBENS, R., DHONT, M., & VERMEULEN, A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1974-07
- Volume
- 39
- Issue
- 1
- Pages
- 40-45
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2092790183
- Cited by
- 270
- References
- 0
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- RUBENS, R., DHONT, M., & VERMEULEN, A. (1974). Further Studies on Leydig Cell Function in Old Age. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-39-1-40
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
