Treatment of Breast Cancer with Testosterone Propionate
Abstract
IN THIS preliminary report no attempt will be made to explain the relationship between sex hormones and cancer in general, the purpose being merely to describe the results obtained with testosterone propionate in three cases of mammary cancer. Among the few reports published on this use of the male sex hormone, the earliest is that of Ulrich (1) who reported the effects in two cases. The first patient, aged 45 years, had had a unilateral mastectomy (left breast) for intracanalicular epithelioma. The right breast was painful, granular and rough to palpation and seemed to be in a preneoplastic or epitheliomatous state. Since malignant transformation such as had occurred in the left breast was feared, amputation of the right breast was contemplated, but before carrying out this procedure Ulrich gave two series of 10 injections of 10 mg. of testosterone acetate. After the first few injections there was a distinct lessening of pain in the right breast and left arm and by the time the treatment was completed the breast had become supple, almost soft, and was no longer of a nodular consistency.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many studies have confirmed beneficial effects of androgens on breast cancer.
“Many studies subsequently confirmed the beneficial effects of androgens on breast cancer (165, 167-174, 251, 252).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [167]
Cites
THE INFLUENCE OF ANDROGENIC AND ESTROGENIC SUBSTANCES ON THE SERUM CALCIUM
Farrow, J. H., & WOODARD, H. Q. (1942) · JAMA · doi:10.1001/jama.1942.02830050001001 · Cited by 88 · see citing works
Subcutaneous Implantation of Female and Male Hormone in Tablet Form in Women
Loeser, A. A. (1940) · BMJ · doi:10.1136/bmj.1.4133.479 · Cited by 44 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
Poulin, R., Baker, D., & Labrie, F. (1988) · Breast Cancer Research and Treatment · doi:10.1007/bf01805942 · Cited by 172 · see citing works
Inhibitory effect of androgens on DMBA-induced mammary carcinoma in the rat.
Dauvois, S., Li, S., Martel, C., & Labrie, F. (1989) · Breast Cancer Research and Treatment · doi:10.1007/bf01806301 · Cited by 47 · see citing works
Couillard, S., Labrie, C., Bélanger, A., Candas, B., Pouliot, F., & Labrie, F. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.10.772 · Cited by 38 · see citing works
Labrie, F., Li, S., B�langer, A., C�t�, J., M�rand, Y., & Lepage, M. (1993) · Breast Cancer Research and Treatment · doi:10.1007/bf00665803 · Cited by 18 · see citing works
- Authors
- Fels, E.
- Corresponding author
- Fels, Eric
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1944-03
- Volume
- 4
- Issue
- 3
- Pages
- 121-125
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2094433584
- Cited by
- 56
- References
- 2
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 4 · 2013: 1 · 2012: 2
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Keywords
- breast cancer, testosterone propionate, androgen therapy, androgens, mastectomy, breast pain, malignant transformation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
