Serum Thyroid Hormone and Thyrotropin Levels in Subjects from Endemic Goiter Regions of New Guinea
Abstract
We studied serum thyroid hormone and thyrotropin (TSH) levels in subjects from two regions (Nomane and KarKar) of New Guinea where endemic goiter and/or iodine deficiency are prevalent. The results of the studies in 285 patients from Nomane indicated subnormal serum T4 (mean plus or minus SD, 6.5 plus or minus 2.8 vs 8.4 plus or minus 2.0 mug/1ll ml, for normal Americans, P less than 0.001), supranormal serum T3 (161 plus or minus 51 vs 126 plus or minus 33, ng/100 ml, p less than 0.001), supranormal serum T3/T4 ratio (T3/T4 x 100, 3.1 plus or minus 2.4 vs 1.5 plus or minus 0.4, P less than 0.001) and supranormal serum TSH (16 plus or minus 40 vs 2.7 plus or minus 1.2 muU/ml, P less than 0.001). Serum free T4 and free T3 were measured in 42 subjects. Serum free T4 was subnormal (2.0 plus or minus 0.9 vs 2.8 plus or minus 0.5, ng/100 ml P less than 0.001) and free T3 was elevated (677 plus or minus 150 vs 375 plus or minus 105, pg/100 ml, P less than 0.001). Serum T4 in goitrous patients was significantly lower than that in non-goitrous patients (5.9 vs 6.9 mug/100 ml, P less than 0.005). However, serum T3 and TSH were no different in the presence or absence of goiter. The frequencies of elevated serum TSH or serum T3 in presence of goiter were also no different from those in its absence. The mean values of various thyroid function tests in 37 subjects from KarKar Island were similar to the corresponding values in Nomane subjects. Serum T4, T3 and TSH values in 8 of 13 deaf-mu…
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In individuals with mild or moderate iodine deficiency, serum T4 levels are low and TSH levels are high, but serum T3 levels remain within the normal reference range.
“A similar scenario is observed in individuals with mild or moderate iodine deficiency. Serum T4 levels are low, and TSH levels are high, but serum T3 levels remain within the normal reference range (20).”
From Emerging Therapies in Hypothyroidism (2024) · cites this paper as [20]
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- Authors
- CHOPRA, I. J., HERSHMAN, J. M., & HORNABROOK, R. W.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1975-02
- Volume
- 40
- Issue
- 2
- Pages
- 326-333
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2030319209
- Cited by
- 106
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- endemic goiter, iodine deficiency, thyroid hormones, thyroid-stimulating hormone, serum thyroxine, serum T3, T3/T4 ratio, free thyroxine, free T3, thyroid function tests, deaf-mutism, New Guinea, Karkar Island, thyroid hormone replacement, iodine supplementation
- MeSH terms
- Adolescent, Adult, Aged, Child, Child, Preschool, Deafness, Female, Goiter, Endemic, Humans, Male, Middle Aged, New Guinea, Thyroid Function Tests, Thyrotropin, Thyroxine, Triiodothyronine
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