Recent developments in thyroid hormone metabolism: interpretation and significance of measurements of reverse T3, 3,3'T2, and thyroglobulin

Burman, Kenneth D.

doi:10.1016/0026-0495(78)90028-8

Cited by 31Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid Surgery

Recent developments in thyroid hormone metabolism: interpretation and significance of measurements of reverse T3, 3,3'T2, and thyroglobulin

Burman, Kenneth D.·1978·Metabolism

DOI 10.1016/0026-0495(78)90028-8

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Abstract

The development of specific radioimmunoassays has allowed measurements of 3,3',5'-triiodothyronine (reverse T3), 3,3'-diiodothyronine (3,3'T2), and thyroglobulin to be performed in serum and in various biological fluids both in normal and in altered states of thyroidal economy. The physiology, kinetics, and metabolic actions of reverse T3, 3,3'T2 and thyroglobulin are reviewed. Presently, it appears that reverse T3 and 3,3'T2 measurements in amniotic fluid and cord serum may potentially be useful in diagnosing fetal or neonatal thyroid dysfunction, and serum thyroglobulin measurements appear to be important as a measure of the efficacy of treatment of patients with differentiated thyroid carcinoma.

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The reciprocal changes in serum T3 and rT3 in patients with severe non-thyroidal diseases represented homeostatic attempts to conserve energy.
“It soon became apparent that the reciprocal changes in serum T3 and rT3 in patients with severe non-thyroidal diseases represented homeostatic attempts to conserve energy (10).”
From Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism? (2019) · cites this paper as [10]

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Authors: Burman, K. D.
Affiliations: Walter Reed National Military Medical Center (US)
Corresponding author: Burman, Kenneth D.
ORCID: Burman, Kenneth D.
Venue: Metabolism
Publisher: Elsevier BV
Published: 1978-05
Volume: 27
Issue: 5
Pages: 615-630
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/0026-0495(78)90028-8
OpenAlex: W2070174457
Cited by: 31
References: 74
Citations by year: 2019: 2 · 2018: 1
FWCI: 5.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords: thyroid hormone metabolism, reverse T3, 3,3'-diiodothyronine, thyroglobulin, radioimmunoassay, amniotic fluid, cord serum, neonatal thyroid dysfunction, differentiated thyroid cancer, treatment response monitoring
MeSH terms: Amniotic Fluid, Female, Fetal Blood, Half-Life, Humans, Kinetics, Metabolic Clearance Rate, Pregnancy, Radioimmunoassay, Thyroglobulin, Thyroid Diseases, Thyroid Gland, Thyroid Neoplasms, Thyronines, Triiodothyronine

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Recent developments in thyroid hormone metabolism: interpretation and significance of measurements of reverse T3, 3,3'T2, and thyroglobulin

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