The DOI matches its Crossref record.
A Diphasic Pattern of Gonadotropin Secretion in Patients with the Syndrome of Gonadal Dysgenesis
Abstract
Cross sectional and longitudinal studies of plasma FSH and LH in 58 patients, age 2 days of 20 yr, with the syndrome of gonadal dysgenesis show a diphasic pattern of gonadotropin secretion. The mean basal plasma FSH level is 43 plus or minus 7 (SE) ng/ml (LER-869) in patients from 2 days to 4 yr, which is strikingly elevated. Thereafter, a decline in plasma FSH to a mean level of 4 plus or minus 0.7 (SE) ng/ml occurs between 4 and 10 yr, followed by a rise after 10 yr to 61 plus or minus 4 (SE) ng/ml. The pattern of LH (LER-960) secretion is qualitatively similar to that of FSH, although quantitatively the values for LH are 1/3 to 1/10 those for FSH. The similarity of pattern of gonadotropin secretion observed between patients with gonadal dysgenesis and normal children suggests that gonadal function does not play a decisive role in the pattern of gonadotropin secretion from infancy through adolescence, but exercises striking effects on the quantity of gonadotropin secreted.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Circulating concentrations of both FSH and LH present a biphasic pattern in TS individuals with hypogonadism: elevated after birth, declining to values similar to girls with normal ovarian function during mid-childhood, and rising again in the peripubertal years, or at the time of loss of ovarian function.”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [268]
Citations
Cites
Still being checked.
Cited by
Sorted by citations
Items 201–276 of 276
Possible Testicular 3β-Hydroxysteroid Dehydrogenase Deficiency in Chryptorchid Neonates
Facchinetti, F., Bracci, R., Sardelli, S., Vanni, M. G., Bagnoli, F., & Genazzani, A. R. (1983) · Archives of Andrology · doi:10.3109/01485018308987575 · Cited by 4
Serum bone GLA protein in streak gonad syndrome
Zséli, J., Bõsze, P., Lakatos, P. L., Vargha, P., Tarján, G., Kollin, E., Horváth, C., László, J., & Holló, I. (1991) · Calcified Tissue International · doi:10.1007/bf02556451 · Cited by 4
The neural basis of puberty and
Sisk, A. L., & Foster, D. L. (2004) · Cited by 4
The Neuroendocrine System and Puberty
Job, J. C. (1977) · Elsevier eBooks · doi:10.1016/b978-0-12-475360-0.50025-0 · Cited by 4
Postnatal Development of GnRH Neuronal Function
Terasawa, E. (2018) · Wiley eBooks · doi:10.1002/9781119233275.ch4 · Cited by 4
Ahmed, A., Haridy, M., Kassab, A. Y., Ahmed, H., Senosy, W., HIRATA, T.-I., & HASHIZUME, T. (2018) · Zagazig Veterinary Journal/Zagazig Veterinary Journal (Online) · doi:10.21608/zvjz.2018.14386 · Cited by 3
Johannsen, T. H., Andersson, A. M., Ahmed, S., de Rijke, Y. B., Greaves, R. F., Hartmann, M. F., Hiort, O., Holterhus, P. M., Krone, N. P., Kulle, A. E., et al. (2021) · Yearbook of pediatric endocrinology · doi:10.1530/ey.18.6.12 · Cited by 3
Haddad, N. G., & Eugster, E. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00122-0 · Cited by 3
Saenger, P. H. (2008) · Elsevier eBooks · doi:10.1016/b978-141604090-3.50020-x · Cited by 3
Neuroendocrine Regulation of Puberty
Terasawa, E., & Ojeda, S. R. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00064-4 · Cited by 4
Grinspon, R. P., & Rey, R. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814823-5.00049-0 · Cited by 3
Menarche: The Transition From Childhood to Womanhood
Eisenberg, E. (1984) · Advances in Pediatrics · doi:10.1016/s0065-3101(24)00204-4 · Cited by 3
Factors Attenuating Growth Promoting Effect of Growth Hormone Therapy for Turner's Syndrome.
Sato, T., Miyamori, C., Kajiwara, S., MIYAGAWA, K., & Shimizu, M. (1988) · Endocrinologia Japonica · doi:10.1507/endocrj1954.35.725 · Cited by 3
Actualitédu syndrome de Turner
Battin, J. (1996) · Archives de Pédiatrie · doi:10.1016/0929-693x(96)83233-7 · Cited by 3
Somatic Growth and its Regulation
Clark, P. A., & Rogol, A. D. (1999) · Comprehensive physiology · doi:10.1002/cphy.cp070502 · Cited by 3
Pituitary Desensitization with a Long-Acting Luteinizing-Hormone-Releasing Hormone Analog
Cutler, G. B., Comite, F., Rivier, J., Vale, W., Loriaux, D. L., & Crowley, W. F. (1983) · Springer eBooks · doi:10.1007/978-1-4899-0354-9_5 · Cited by 3
Entwicklung der endokrinen Systeme und Fortpflanzungsorgane – Varianten der Geschlechtsentwicklung
Hiort, O., & Strowitzki, T. (2024) · Springer eBooks · doi:10.1007/978-3-662-65517-7_2 · Cited by 2
Hormonal Function of Undescended Testes Before Orchidopexy in Prepubertal Boys
Walczak-Jędrzejowska, R., Niedzielski, J., Słowikowska‐Hilczer, J., Nowak, M., & Marchlewska, K. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm14010073 · Cited by 2
Syndrome de Turner et isoformes de LH et FSH. Intérêt des techniques enzymatiques polyclonales
Pétrus, M., Rittié, J. L., Causse, J., Moulie, N., Rhabbour, M., Netter, J. C., Hirsch, C., & Bildstein, G. (1996) · Archives de Pédiatrie · doi:10.1016/0929-693x(96)81302-9 · Cited by 2
Federman, D. D. (1979) · PubMed Central · Cited by 2
Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn Infant
Cuttler, L., & Palmert, M. R. (2004) · Elsevier eBooks · doi:10.1016/b978-0-7216-9654-6.50188-0 · Cited by 2
The Normal Human Ovary Part I: Reproductive and Endocrine Functions
KASE, N. G. (2003) · Elsevier eBooks · doi:10.1016/b978-012053642-9/50006-5 · Cited by 2
Witchel, S. F., & Plant, T. M. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4907-4.00017-6 · Cited by 3
Uncoupling of the Infancy Life History Stage
Hochberg, Z. (2021) · Hormone Research in Paediatrics · doi:10.1159/000517264 · Cited by 2
Ovarian Dysfunction in the Adolescent
Huppert, L. C. (1983) · Springer eBooks · doi:10.1007/978-1-4615-8324-0_3 · Cited by 2
DiVall, S. A., & Blasi, C. C. D. (2016) · Endocrinology · doi:10.1007/978-3-319-27318-1_25-1 · Cited by 2
Neuroendocrine Regulation of Puberty
Terasawa, E., & Levine, J. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00106-1 · Cited by 2
Endokrinologie der Kindheit und der Pubertät
Leidenberger, F. A. (1992) · Springer eBooks · doi:10.1007/978-3-662-08110-5_7 · Cited by 2
Functional hypothalamic amenorrhea
Berga, S. L. (2001) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200112000-00008 · Cited by 2
Endokrinologie der Kindheit, der Pubertät und der Adoleszenz
Roth, C. L., Hiort, O., & Jung, H. (2009) · Springer eBooks · doi:10.1007/978-3-540-89760-6_4 · Cited by 1
Styne, D. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-18371-8_9 · Cited by 1
Control of Puberty in Non-Human Primates
Plant, T. M. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-499-5_2 · Cited by 1
The normal human ovary part I: reproductive and endocrine functions
KASE, N. G. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139003254.002 · Cited by 1
Phenotypic Correlations of X-Chromosome Loss
Neely, E. K., & Rosenfeld, R. G. (1994) · Elsevier eBooks · doi:10.1016/b978-0-12-728960-1.50018-5 · Cited by 1
Wolfgram, P. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-39956-2.00042-x · Cited by 1
DiVall, S. A., & Blasi, C. C. D. (2018) · Endocrinology · doi:10.1007/978-3-319-44675-2_25 · Cited by 2
Stepwise evaluation of the short child
Stelling, M. W. (1986) · Postgraduate Medicine · doi:10.1080/00325481.1986.11699391 · Cited by 1
Sex chromosome aberrations and genetic consequences
Anhalt, H., & Neely, E. K. (1996) · Advances in genome biology · doi:10.1016/s1067-5701(96)80007-6 · Cited by 1
Control of ovarian function by the immune system: Is this a plausible and necessary hypothesis?
Schenzle, D. (1980) · Medical Hypotheses · doi:10.1016/0306-9877(80)90006-7 · Cited by 1
Pituitary and ovarian response to PMSG and GnRH of a gonadal dysgenetic buffalo
Singh, C. V., & Madan, M. L. (1997) · Veterinary Record · doi:10.1136/vr.140.20.533 · Cited by 1
Endokrinologie der Kindheit, Pubertät und Adoleszenz
Jung, H. (2005) · Springer eBooks · doi:10.1007/3-540-26406-x_4 · Cited by 1
STUDIES ON PITUITARY-GONADAL ENDOCRINE FUNCTION IN PATIENTS WITH MALE HERMAPHRODITISM
Ishida, H. (1979) · The Japanese Journal of Urology · doi:10.5980/jpnjurol1928.70.6_655 · Cited by 1
The Hypothalamic–Pituitary Unit: The Maturation of the Neuroendocrine System in the Fetus
Gluckman, P. D. (1982) · Elsevier eBooks · doi:10.1016/b978-0-12-093602-1.50008-6 · Cited by 1
Vliet, G. V. (2011) · doi:10.1093/med/9780199235292.003.7016 · Cited by 1
Francisco, J. R. R., Burón, P., Blanc, F., Martínez, E. P., & Sánchez, M. B. (1997) · Anales de Pediatría
Wickman, S. (2003) · Työväentutkimus Vuosikirja
Study on the prevalence of metabolic syndrome in Turner syndrome
Cantamessa, G., Gertosio, C., & Toglia, R. (2014) · Università degli Studi di Pavia · doi:10.6092/2039-1404.126.1647
Long-term variations in plasma gonadotropins in early castrated male rabbits
Berger, M., Jean‐Faucher, C., de Turckheím, M., VEYSSIERE, G., & Jean, C. (1984) · Journal of Endocrinological Investigation · doi:10.1007/bf03348424
Photoaffinity labeling of the follitropin receptor
Ji, T. H., & Shin, J. (1989) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(89)90015-6
Puberty and reproductive health: Diseases caused by hormone insufficiency and hormone resistance
Spremović-Radjenović, S., Lazovic, G., & Nikolić, B. (2006) · Vojnosanitetski pregled · doi:10.2298/vsp0612021s
Endokrinologie der Kindheit und Pubertät
Leidenberger, F. A. (1998) · Springer eBooks · doi:10.1007/978-3-662-08108-2_7
Dysgénésies gonadiques de phénotype féminin
Battin, J. (2004) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(04)74271-7
Rudolf, K. D., Kyank, H., Göretzlehner, G., & Kunkel, S. (1980) · Archives of Gynecology and Obstetrics · doi:10.1007/bf02109953
Wu, F. C. W. (1988) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-09961-0_6
Changes in pituitary prolactin reserve with sexual maturation
Omura, T. (1989) · Okayama Igakkai Zasshi (Journal of Okayama Medical Association) · doi:10.4044/joma1947.101.11-12_1063
Growth Hormone Therapy in Children with Turner Syndrome, Noonan Syndrome, and SHOX Gene Mutations
Backeljauw, P. F., & Gutmark‐Little, I. (2018) · Springer eBooks · doi:10.1007/978-3-319-73782-9_6
Estrogen Replacement in Turner Syndrome
Klein, K. O., Rosenfield, R. L., Santen, R. J., Gawlik, A., Backeljauw, P. F., Gravholt, C. H., Sas, T., & Mauras, N. (2020) · Springer eBooks · doi:10.1007/978-3-030-34150-3_5
Zarei, F., Mobini, M., Esfehani, R. J., Khalesi, M., & Vakili, R. (2021) · International journal of pediatrics · doi:10.22038/ijp.2020.54327.4296
Does residual virus replication during successful HAART lead to HIV-1 genetic evolution?
Aquaro, S., Svicher, V., & Perno, C. F. (2006) · PubMed
Identification of hypothalamic sites that control puberty onset and sexual maturation
Greenwald-Yarnell, M. L. (2013) · Deep Blue (University of Michigan)
Davenport, M. L., ROSS, J. L., & Backeljauw, P. F. (2013) · Humana Press eBooks · doi:10.1007/978-1-60761-395-4_7
Heinrich, U., & Gerhard, I. (1987) · Springer eBooks · doi:10.1007/978-3-642-71568-6_9
Heinrich, U., & Gerhard, I. (1997) · Springer eBooks · doi:10.1007/978-3-642-60390-7_7
Daughaday, W. H. (1976) · Springer eBooks · doi:10.1007/978-1-4615-8843-6_2
Waguespack, S. G., & Pescovitz, O. H. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-156-5_15
Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn Infant
Narasimhan, S., Clemente, E. G., & Vyas, N. V. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00145-1
Haddad, N. G., & Eugster, E. A. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00122-2
Kannan, C. R. (1986) · Springer eBooks · doi:10.1007/978-1-4899-1692-1_42
Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn
Narasimhan, S., Palmert, M. R., & Cuttler, L. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-3479-7.10179-x
Wolfgram, P. M., & Auble, B. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-76174-1.00055-9
Growth Hormone Therapy in Children with Turner Syndrome, Noonan Syndrome, and SHOX Gene Mutations
Gutmark‐Little, I., Muthuvel, G., & Backeljauw, P. F. (2024) · Springer eBooks · doi:10.1007/978-3-031-66296-6_6
Styne, D. M. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-277-7_20 · Cited by 2
Felix A. Conte, MD, 1935–2024: The Endocrinologist’s Endocrinologist
Miller, W. L., Rosenthal, S. M., Gitelman, S. E., Lustig, R. H., & Styne, D. M. (2025) · Hormone Research in Paediatrics · doi:10.1159/000543610
Somatic Growth and its Regulation
Clark, P. A., & Rogol, A. D. (1998) · Comprehensive physiology · doi:10.1002/j.2040-4603.1998.tb01532.x
Grinspon, R. P., & Rey, R. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-23940-3.00008-9
Shahab, M., Trujillo, M. V., & Plant, T. M. (2015) · Endocrinology · doi:10.1210/en.2015-1421
Metadata
- Authors
- CONTE, F. A., GRUMBACH, M. M., & KAPLAN, S. L.
- Affiliations
- University of California, San Francisco (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1975-04
- Volume
- 40
- Issue
- 4
- Pages
- 670-674
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2104675247
- Cited by
- 276
- References
- 0
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 10 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 6
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- gonadal dysgenesis, follicle-stimulating hormone, luteinizing hormone, plasma gonadotropin levels, adolescence, gonadal function, Kallmann syndrome
- MeSH terms
- Adolescent, Adult, Age Factors, Child, Child, Preschool, Estradiol, Estrone, Female, Follicle Stimulating Hormone, Humans, Infant, Infant, Newborn, Luteinizing Hormone, Radioimmunoassay, Turner Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
