Cited by 276Hypothalamic control of reproductive hormonesSexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

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A Diphasic Pattern of Gonadotropin Secretion in Patients with the Syndrome of Gonadal Dysgenesis

CONTE, FELIX A., GRUMBACH, MELVIN M., KAPLAN, SELNA L.·1975·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-40-4-670

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Abstract

Cross sectional and longitudinal studies of plasma FSH and LH in 58 patients, age 2 days of 20 yr, with the syndrome of gonadal dysgenesis show a diphasic pattern of gonadotropin secretion. The mean basal plasma FSH level is 43 plus or minus 7 (SE) ng/ml (LER-869) in patients from 2 days to 4 yr, which is strikingly elevated. Thereafter, a decline in plasma FSH to a mean level of 4 plus or minus 0.7 (SE) ng/ml occurs between 4 and 10 yr, followed by a rise after 10 yr to 61 plus or minus 4 (SE) ng/ml. The pattern of LH (LER-960) secretion is qualitatively similar to that of FSH, although quantitatively the values for LH are 1/3 to 1/10 those for FSH. The similarity of pattern of gonadotropin secretion observed between patients with gonadal dysgenesis and normal children suggests that gonadal function does not play a decisive role in the pattern of gonadotropin secretion from infancy through adolescence, but exercises striking effects on the quantity of gonadotropin secreted.

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Authors: CONTE, F. A., GRUMBACH, M. M., & KAPLAN, S. L.
Affiliations: University of California, San Francisco (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1975-04
Volume: 40
Issue: 4
Pages: 670-674
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-40-4-670
OpenAlex: W2104675247
Cited by: 276
References: 0
Citations by year: 2025: 2 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 10 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 6
FWCI: 5.71
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Keywords: gonadal dysgenesis, follicle-stimulating hormone, luteinizing hormone, plasma gonadotropin levels, adolescence, gonadal function, Kallmann syndrome
MeSH terms: Adolescent, Adult, Age Factors, Child, Child, Preschool, Estradiol, Estrone, Female, Follicle Stimulating Hormone, Humans, Infant, Infant, Newborn, Luteinizing Hormone, Radioimmunoassay, Turner Syndrome

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A Diphasic Pattern of Gonadotropin Secretion in Patients with the Syndrome of Gonadal Dysgenesis

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