Catecholamines Metabolism in Thyroid Diseases. I. Epinephrine Secretion Rate in Hyperthyroidism and Hypothyroidism
Abstract
We have measured the secretion rate of epinephrine in 6 euthyroid, 6 hyperthyroid, and 6 hypothyroid subjects infused at a constant rate for a one hour period with tritiated epinephrine (.01 muc/kg/min) (New England Nuclear Inc.). Plasma and urinary levels of epinephrine were measured by modifying the fluorometric method of Anton and Sayre. Plasma levels of epinephrine were 3.0 +/- 3.0 ng/100 ml (mean +/- SD) in normal subjects, compared to 4.4 +/- 3.5 ng/100 ml (mean +/- SD) in hyperthyroid subjects. In urine, epinephrine values ranged from 1.3 mug/day to 6.1 mug/day in normal subjects. Mean value observed in hyperthyroidism was 4.9 +/- 2.6 mug/day and 3.8 +/- 1.0 mu/day in hypothyroidism. Plasma secretion rates averaged 48 +/- 27 mug/kg/day in normal subjects, compared to 54 +/- 18 mu/kg/day in hyperthyroidism and 43 +/- 20 mug/kg/day in hypothyroidism. Likewise, the mean urinary secretion rate was 55 +/- 27 mug/kg/day in normal subjects compared to 60 +/- 22 mug/kg/day in hyperthyroidism and 50 +/- 28 mug/kg/day in hypothyroidism. There is no statistical difference between the values found in the three groups of subjects (plasma and urine). Therefore, these results would indicate that the signs and symptoms encountered in hyperthyroidism are not secondary to a high secretion rate of epinephrine.
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Thyroid Hormone Regulation of Metabolism
Mullur, R., Liu, Y.-Y., & Brent, G. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00030.2013 · Cited by 2,421 · see citing works
“Direct measurement of epinephrine secretion shows no difference in hyperthyroid or hypothyroid patients (47).”
BackgroundCardiovascular and Atherogenic Aspects of Subclinical Hypothyroidism
Kahaly, G. J. (2000) · Thyroid · doi:10.1089/10507250050137743 · Cited by 310 · see citing works
Chiha, M., Samarasinghe, S., & Kabaker, A. S. (2013) · Journal of Intensive Care Medicine · doi:10.1177/0885066613498053 · Cited by 262 · see citing works
“Prior studies evaluating catecholamine metabolism in patients with hyperthyroidism have failed to demonstrate elevated plasma concentrations or increased secretion rates of epinephrine or norepinephrine compared to patients with hypothyroidism and euthyroidism, which argues against a primary adrenergic system defect.(…”
BackgroundCatecholamine-thyroid hormone interactions and the cardiovascular manifestations of hyperthyroidism
Levey, G. S., & Klein, I. L. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90533-j · Cited by 212 · see citing works
Tietgens, S. T., & Leinung, M. C. (1995) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30090-6 · Cited by 160 · see citing works
Plasma catecholamine concentrations in hyperthyroidism and hypothyroidism
Coulombe, P., Dussault, J. H., & Walker, P. (1976) · Metabolism · doi:10.1016/0026-0495(76)90126-8 · Cited by 132 · see citing works
Self-citationSarlis, N. J., & Gourgiotis, L. (2003) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1022933918182 · Cited by 112 · see citing works
Graves' disease: An analysis of thyroid hormone levels and hyperthyroid signs and symptoms
Trzepacz, P. T., Klein, I., Roberts, M., Greenhouse, J., & Levey, G. S. (1989) · The American Journal of Medicine · doi:10.1016/s0002-9343(89)80614-x · Cited by 110 · see citing works
Effects of Thyroid Hormone on Cardiac β-Adrenergic Responsiveness in Conscious Baboons
Hoit, B. D., Khoury, S. F., Shao, Y., Gabel, M., Liggett, S. B., & Walsh, R. A. (1997) · Circulation · doi:10.1161/01.cir.96.2.592 · Cited by 109 · see citing works
Ginsberg, A. M., Clutter, W. E., Shah, S. D., & Cryer, P. E. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110218 · Cited by 99 · see citing works
Hypertension in Thyroid Disorders
Saito, I., & Samta, T. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30103-8 · Cited by 93 · see citing works
Chen, J., Chiu, H., Tseng, Y., & Chu, W. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02514.x · Cited by 86 · see citing works
Novel neural pathways for metabolic effects of thyroid hormone
Fliers, E., Klieverik, L. P., & Kalsbeek, A. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.11.008 · Cited by 80 · see citing works
Sympathovagal imbalance in hyperthyroidism
Burggraaf, J., Tulen, J. H. M., Lalezari, S., Schoemaker, R. C., Meyer, P., Meinders, A. E., Cohen, A. F., & Pijl, H. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.1.e190 · Cited by 80 · see citing works
Gut-thyroid interrelationships
Miller, L. J., Gorman, C. A., & Go, V. L. W. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)90478-x · Cited by 69 · see citing works
Catecholamines and hyperthyroidism
Landsberg, L. (1977) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(77)80076-5 · Cited by 67 · see citing works
Gelfand, R., Hutchinson-Williams, K. A., Bonde, A. A., Castellino, P., & Sherwin, R. S. (1987) · Metabolism · doi:10.1016/0026-0495(87)90168-5 · Cited by 65 · see citing works
Insulin resistance in Graves' disease: a quantitative<i>in‐vivo</i>evaluation
CAVALLO‐PERIN, P., BRUNO, A., BOINE, L., CASSADER, M., LENTI, G., & PAGANO, G. (1988) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1988.tb01275.x · Cited by 58 · see citing works
Thyroid hormones in the regulation of brown adipose tissue thermogenesis
Sentis, S. C., Oelkrug, R., & Mittag, J. (2021) · Endocrine Connections · doi:10.1530/ec-20-0562 · Cited by 60 · see citing works
Braverman, L. E. (1978) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(78)80044-9 · Cited by 53 · see citing works
Mano, T., Sakamoto, H., Fujita, K., Makino, M., Kakizawa, H., Nagata, M., Kotake, M., Hamada, M., Uchimura, K., Hayakawa, N., et al. (1998) · Thyroid · doi:10.1089/thy.1998.8.353 · Cited by 47 · see citing works
Psychiatric and neuropsychological response to propranolol in Graves' disease
Trzepacz, P. T., McCue, M. P., Klein, I. L., Greenhouse, J. B., & Levey, G. S. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90051-0 · Cited by 43 · see citing works
Bush, R. K., Ehrlich, E. N., & Reed, C. E. (1977) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(77)90025-2 · Cited by 43 · see citing works
Catecholamines and the Sympathoadrenal System
Landsberg, L. (1976) · Springer eBooks · doi:10.1007/978-1-4615-8843-6_8 · Cited by 35 · see citing works
Ward, C. R. (2007) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2007.03.002 · Cited by 32 · see citing works
“In human beings, it has been shown that serum and urine catecholamine levels are within normal limits during thyroid storm [12].”
BackgroundVoltammetric Determination of Epinephrine in Pharmaceutical Sample with a Tyrosinase Nanobiosensor
Alpat, Ş., Özdemir, K., & Alpat, S. K. (2016) · Journal of Sensors · doi:10.1155/2016/5653975 · Cited by 30 · see citing works
“5 ng/100mL (mean ± SD) with the hypothyroid subject groups [6].”
BackgroundThe Effect of Age on Blood Pressure in Hyperthyroidism
Saito, I., Ito, K., & Saruta, T. (1985) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1985.tb02854.x · Cited by 30 · see citing works
Hassan, W. A., Aly, M. S., Rahman, T. A., & Shahat, A. S. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.02.001 · Cited by 23 · see citing works
Exercise Performance in Young and Middle-Aged Female Patients with Subclinical Hyperthyroidism
Portella, R. B., Silva, J. L. D. C., Wagman, M. B., de Oliveira, F. P., Buescu, A., & Vaisman, M. (2006) · Thyroid · doi:10.1089/thy.2006.16.731 · Cited by 23 · see citing works
The Surgical Management of Thyroid-related Upper Eyelid Retraction
Dixon, R. S. (1982) · Ophthalmology · doi:10.1016/s0161-6420(82)34861-7 · Cited by 22 · see citing works
Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis
Brusseau, V., Tauveron, I., Bagheri, R., Ugbolue, U. C., Magnon, V., Bouillon‐Minois, J., Navel, V., & Dutheil, F. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063606 · Cited by 20 · see citing works
“Hyperthyroidism is characterized by a hyperkinetic state, similar to that induced by catecholamine excess [6], but serum and urine catecholamine levels are normal or decreased in hyperthyroidism [63,64].”
BackgroundAnemia: A Cause of Intolerance to Thyroxine Sodium
Shakir, K. M. M., Turton, D. B., Aprill, B. S., Drake, A. J., & Eisold, R. J. F. (2000) · Mayo Clinic Proceedings · doi:10.4065/75.2.189 · Cited by 18 · see citing works
Guimarães, F. C., & Cruz, A. A. V. E. (1995) · Ophthalmology · doi:10.1016/s0161-6420(95)30887-1 · Cited by 17 · see citing works
Portella, R. B., Pedrosa, R. C., Coeli, C. M., Buescu, A., & Vaisman, M. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02879.x · Cited by 17 · see citing works
Hypothyroidism Complicated by Angina Pectoris: Therapeutic Approaches
Ellyin, F. M., Kumar, Y., & Somberg, J. C. (1992) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1992.tb03893.x · Cited by 16 · see citing works
Assessment of cardiac vagal activity in patients with hyperthyroidism
Pitzalis, M. V., Mastropasqua, F., Massari, F., Ciampolillo, A., Passantino, A., Ognissanti, M., Mannarini, A., Zanna, D., GIORGINO, R., & RIZZON, P. (1998) · International Journal of Cardiology · doi:10.1016/s0167-5273(98)00024-2 · Cited by 14 · see citing works
Influence of hypo- and hyperthyroidism on plasma catecholamines in pithed rats
Nagel‐Hiemke, M., Gro�, G., Lues, I., & Sch�mann, H.-J. (1981) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00500073 · Cited by 14 · see citing works
Triiodothyronine, β-adrenergic receptors, agonist responses, and exercise capacity
Martin, W. H. (1993) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(93)90551-r · Cited by 14 · see citing works
Thyroid Emergencies: A Narrative Review
Kruithoff, M., & Gigliotti, B. J. (2025) · Endocrine Practice · doi:10.1016/j.eprac.2025.06.010 · Cited by 17 · see citing works
Cardiac changes in experimental hyperthyroidism in dogs
Hoey, A. J., PAGE, A., Brown, L., & Atwell, R. B. (1991) · Australian Veterinary Journal · doi:10.1111/j.1751-0813.1991.tb00733.x · Cited by 11 · see citing works
Hypertension in hyperthyroidism: Is there an epinephrine connection?
Kuchel, O., Buu, N. T., Hamet, P., & Larochelle, P. M. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90276-4 · Cited by 11 · see citing works
Hypothyroidism with angina pectoris
Ellyin, F. M., Fuh, C.-Y., Singh, S. P., & Kumar, Y. (1986) · Postgraduate Medicine · doi:10.1080/00325481.1986.11699412 · Cited by 9 · see citing works
Brusseau, V., Tauveron, I., Bagheri, R., Ugbolue, U. C., Magnon, V., Bouillon‐Minois, J., Navel, V., & Dutheil, F. (2022) · Biomedicines · doi:10.3390/biomedicines10081982 · Cited by 8 · see citing works
Chen, J.-L., Shiau, Y.-H., Tseng, Y.-J., Chiu, H., Hsiao, T., Wessel, N., Kurths, J., & Chu, W. (2010) · Physica A Statistical Mechanics and its Applications · doi:10.1016/j.physa.2009.12.062 · Cited by 8 · see citing works
Pathophysiology of sympathoadrenal system
GIORGINO, R. (1988) · Journal of Endocrinological Investigation · doi:10.1007/bf03350236 · Cited by 7 · see citing works
Calcium mobilization and sensitivity in intact and triton skinned aorta from thyropathologic rats
Stratton, D. B., & Morrow, R. J. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90334-8 · Cited by 5 · see citing works
Bramnert, M., Hallengren, B., LECEROF, H., Werner, R., & Manhem, P. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb03925.x · Cited by 5 · see citing works
Models of Cardiac Development: Transplants, Organ Culture, Cell Dispersion, and Cell Culture
Robinson, R. B. (1984) · Springer eBooks · doi:10.1007/978-1-4613-3834-5_5 · Cited by 5 · see citing works
Perfusion Technology in the Hypothyroid Patient
Vertrees, R. A., Engelman, R. M., Haag, B. L., Rousou, J. H., Anvil, J., & Rohrer, C. H. (1981) · CHEST Journal · doi:10.1378/chest.79.2.167 · Cited by 4 · see citing works
Bürgi, H., Labhart, A., Hedinger, C. E., Kistler, G., & Prader, A. (1978) · Springer eBooks · doi:10.1007/978-3-662-08098-6_6 · Cited by 4 · see citing works
Probable hypothyroid myopathy: Glycogendeficient type 2b fibers
Wheeler, S. D., & Ochoa, J. L. (1978) · Muscle & Nerve · doi:10.1002/mus.880010609 · Cited by 3 · see citing works
Bürgi, H. (1986) · Springer eBooks · doi:10.1007/978-3-642-70509-0_6 · Cited by 3 · see citing works
Thyroid Heart Disease in the Elderly
Miller, M., & Gambert, S. R. (2008) · Fundamental and clinical cardiology · doi:10.3109/9781420061710.020 · Cited by 2 · see citing works
Straznicka, M., Leone, R. J., Scholz, P., & Weiss, H. R. (1998) · Journal of Surgical Research · doi:10.1006/jsre.1997.5292 · Cited by 2 · see citing works
Philipp, T., Brokamp, B., Cordes, U., Lüth, B., & Distler, A. (1979) · Verhandlungen der Deutschen Gesellschaft für Innere Medizin · doi:10.1007/978-3-642-85454-5_256 · Cited by 2 · see citing works
Hyperthyroidism and “Thyroid Storm”
Woerlee, G. M. (1988) · Developments in critical care medicine and anestesiology · doi:10.1007/978-94-009-1323-3_52 · Cited by 2 · see citing works
Thyroid Disorders During Pregnancy, Postpartum, and Lactation
Quandt, Z., Salmeen, K. E., & Block-Kurbisch, I. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814823-5.00019-2 · Cited by 1 · see citing works
Woeber, K. A., & Braverman, L. E. (1979) · Springer eBooks · doi:10.1007/978-1-4757-4857-4_3 · Cited by 1 · see citing works
Wissler, R. N. (2009) · Elsevier eBooks · doi:10.1016/b978-0-323-05541-3.00042-9 · Cited by 1 · see citing works
Isales, C. M. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-911-0_10 · Cited by 1 · see citing works
Ferdous, H., Afsana, F., Qureshi, N. K., Rouf, R. S. B., Parvez, A., & Mir, A. (2016) · Journal of Bangladesh College of Physicians and Surgeons · doi:10.3329/jbcps.v33i3.28059 · Cited by 1 · see citing works
Hariman, C., Pelluri, L., & O'Weickert, M. (2014) · Endocrine Abstracts · doi:10.1530/endoabs.34.p384
Studies on metabolic alterations after a mixed meal and during a 39-hour fast in thyrotoxicosis
Federspil, G., Zaccaria, M., Sicolo, N., Palo, C. D., Zago, E., Boninsegna, A., Bevilacqua, M., & Scandellari, C. (1979) · Journal of Endocrinological Investigation · doi:10.1007/bf03349314
Responses of Plasma Bradykinin and Renin Angiotensin Axis to Angiotensin II in Hyperthyroid Patients
Takeda, Y., Miyamori, I., IKEDA, M., KOSHIDA, H., Okamoto, S., Yasuhara, S., Morise, T., Kawato, M., & Takeda, R. (1986) · Folia Endocrinologica Japonica · doi:10.1507/endocrine1927.62.2_61
THERAPEUTIC PROGRESS-REVIEW X.
Wilkinson, R. (1983) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.1983.tb01054.x
Functional state of the autonomic nervous system in patients with euthyroid and thyrotoxic goiter
Александров, В. Н., Sz, K., Shukhgalter, I. A., Akatov, I. V., Nikitina, T. I., & Gorbatyi, B. I. (1986) · Neuroscience and Behavioral Physiology · doi:10.1007/bf01191461
Kobayashi, M., Shimoda, S.-I., & Kasai, K. (1978) · Folia Endocrinologica Japonica · doi:10.1507/endocrine1927.54.2_143
Ferdous, H., Afsana, F., Qureshi, N. K., Rouf, R. S. B., Parvez, A., & Mir, A. (2016) · Journal of Medicine · doi:10.3329/jom.v17i2.30073
Endocrine Hypertensive Emergencies
Egan, C. E., Greenberg, J. A., & Fahey, T. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-84737-1_42
Woeber, K. A., & Braverman, L. E. (1978) · Springer eBooks · doi:10.1007/978-1-4684-2502-4_3
Grant, S. B., & Trooskin, S. Z. (2016) · Springer eBooks · doi:10.1007/978-3-319-33341-0_31
Waldhäusl, W. K., & Bratusch-Marrain, P. R. (1980) · Springer eBooks · doi:10.1007/978-3-642-96451-0_10
Nicholls, M. G. (1984) · Elsevier eBooks · doi:10.1016/b978-0-407-00346-0.50015-5
- Authors
- COULOMBE, P., DUSSAULT, J. H., LETARTE, J., & SIMARD, S. J.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- DUSSAULT, J. H.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1976-01
- Volume
- 42
- Issue
- 1
- Pages
- 125-131
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W4299969387
- Cited by
- 74
- References
- 0
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 1 · 2016: 4 · 2014: 2 · 2013: 2
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- catecholamine metabolism, hyperthyroidism, hypothyroidism, thyroid dysfunction, plasma epinephrine, urinary epinephrine
- MeSH terms
- Epinephrine, Female, Humans, Hyperthyroidism, Hypothyroidism, Male, Norepinephrine, Secretory Rate, Thyroid Gland
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