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Glycosylated Hemoglobins and Long-Term Blood Glucose Control in Diabetes Mellitus
Abstract
The glycosylated minor hemoglobin components Hb A1a+b and HbA1c are elevated in insulin-dependent juvenile diabetic patients, 3.2+/-0.7 (+/-1 SD) and 10.0+/-1.9% of total hemoglobin respectively, versus 2.1+/-0.4 and 4.9+/-0.7% in a normal non-diabetic control population. Total glycosylated hemoglobin components, Hb A1a+b+c, correlated with the degree of diabetic blood glucose regulation as measured by antecedent 24-h urinary glucose excretion determined in 220 diabetic patients immediately before, 1, 2, and 3 months prior to the HB A1a+b+c measurement. This assay for long-term blood glucose regulation was utilized to determine the effect of hyperglycemia on plasma cholesterol levels in 112 diabetic patients. Hb A1a+b+c levels correlated with plasma cholesterol levels, suggesting that long-term hyperglycemia is associated with hypercholesterolemia. It is suggested that glycosylated hemoglobin measurement is a good index of long-term blood glucose levels in diabetic patients.
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Cited by
Hemoglobin Carbamylation in Uremia
Flückiger, R., Harmon, W., Meier, W., Loo, S., & Gabbay, K. H. (1981) · New England Journal of Medicine · doi:10.1056/nejm198104023041406 · Cited by 262
Self-citationReliability of blood glucose monitoring by patients with diabetes mellitus
Mazze, R. S., Shamoon, H., Pasmantier, R., Lucido, D., Murphy, J., Hartmann, K., Kuykendall, V., & Lopatin, W. (1984) · The American Journal of Medicine · doi:10.1016/0002-9343(84)90693-4 · Cited by 261
Larsen, M. L., Hørder, M., & Mogensen, E. F. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010113231503 · Cited by 257
Nonenzymatic glycosylation of protein: relevance to diabetes
Bunn, H. F. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90769-5 · Cited by 171
Self-citationEffects of acute changes in blood glucose on HbA1c
Goldstein, D. E., Peth, S. B., England, J. D., Hess, R. L., & Costa, J. D. (1980) · Diabetes · doi:10.2337/diab.29.8.623 · Cited by 145
Metadata
- Authors
- GABBAY, K. H., HASTY, K., BRESLOW, J. L., ELLISON, R. C., BUNN, H. F., & GALLOP, P. M.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1977-05
- Volume
- 44
- Issue
- 5
- Pages
- 859-864
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1989896488
- Cited by
- 520
- References
- 0
- FWCI
- 37.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Glycosylated Hemoglobins and Long-Term Blood Glucose Control in Diabetes Mellitus. https://app.cochat.ai/papers/10.1210/jcem-44-5-859
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- GABBAY, K. H., HASTY, K., BRESLOW, J. L., ELLISON, R. C., BUNN, H. F., & GALLOP, P. M. (1977). Glycosylated Hemoglobins and Long-Term Blood Glucose Control in Diabetes Mellitus. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-44-5-859
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
