Adrenocorticotropin Release by Tryptophan in Man*
Abstract
Previous work from this laboratory indicated significant elevations of cortisol after the administration of tryptophan. The current investigation was designed to confirm this observation and study the effect of this agent on ACTH. Cortisol rose 12.4 +/- 5.2 microgram/dl (mean +/- SD) in 10 of 12 tests (P less than 0.02). Responding patients had rises of ACTH averaging 101.8 +/- 45.8% (range, 40-159 pg/ml) above baseline. The time course of the ACTH change closely paralleled that of cortisol, and there were significant correlations between the rises of the two substances (r = 0.81; P less than 0.01). The current data strongly suggest that tryptophan administration stimulates ACTH release, possibly through activation of the central serotonergic nervous system. Review of the literature suggests the possibility that ACTH stimulation only occurs at high plasma tryptophan (and presumably brain serotonin) concentrations, with ACTH inhibition occuring at lower levels.
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Ingestion of glucose, amino acids, protein, or mixed meals tends to increase serum and salivary cortisol concentrations in healthy adults.
“Ingestion of glucose, amino acids, protein, or mixed meals tends to increase serum and salivary cortisol concentrations in healthy adults (1–8).”
From Glucose ingestion selectively amplifies ACTH and cortisol secretory-burst mass and enhances their joint synchrony in healthy men. (2011) · cites this paper as [3]
Under physiological conditions, both ACTH-dependent and ACTH-independent mechanisms of food-induced cortisol secretions have been postulated.
“Indeed, under physiological conditions, both ACTH-dependent and ACTH-independent mechanisms of food-induced cortisol secretions have been postulated (3, 13–15).”
From Glucose ingestion selectively amplifies ACTH and cortisol secretory-burst mass and enhances their joint synchrony in healthy men. (2011) · cites this paper as [3]
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- Authors
- MODLINGER, R. S., SCHONMULLER, J. M., & ARORA, S. P.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1980-02
- Volume
- 50
- Issue
- 2
- Pages
- 360-363
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2082459394
- Cited by
- 41
- References
- 27
- Citations by year
- 2017: 1 · 2016: 1 · 2012: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- tryptophan, ACTH, ACTH release, cortisol, serotonergic system, central nervous system, hypothalamic-pituitary-adrenal axis
- MeSH terms
- Adrenocorticotropic Hormone, Humans, Hydrocortisone, Kinetics, Tryptophan
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