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THERAPEUTIC USE OF PITUITARY OESENSITIZATION WITH A LONG-ACTING LHRM AGONIST: A POTENTIAL NEW TREATMENT FOR IDIOPATHIC PRECOCIOUS PUBERTY*
Abstract
A two year girl with idiopathic true precocious puberty was treated with a long-acting LHRH agonist, D-Trp6-Pro9-NEt-LHRH (LHRHa). Prior to therapy, the patient demonstrated pulsatile gonadotropin secretion during both night and day, a pubertal response to exogenous LHRH, and an elevated plasma estradiol level. After eight weeks of therapy (4 microgram/kg daily), a mean gonadotropin levels fell to the prepubertal range, there was no evidence of pulsatile discharge of gonadotropins nor any response to exogenous LHRH, and plasma estradiol levels became undetectable. No adverse drug reactions were encountered and all effects of therapy were reversed following cessation of treatment for two months. LHRH analogs may offer a new approach to the therapy of idiopathic precocious puberty and merit further study.
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Citations
Cited by
Consensus Statement on the Use of Gonadotropin-Releasing Hormone Analogs in Children
Carel, J.-C., Eugster, E. A., Rogol, A., Ghizzoni, L., Palmert, M. R., & on behalf of the members of the ESPE-LWPES GnRH Analogs Consensus Conference Group (2009) · Pediatrics · doi:10.1542/peds.2008-1783 · Cited by 817
Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
Pinilla, L., Aguilar, E., Dieguez, C., Millar, R. P., & Tena-Sempere, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2010 · Cited by 801
Leuprolide versus Diethylstilbestrol for Metastatic Prostate Cancer
The Leuprolide Study Group (1984) · New England Journal of Medicine · doi:10.1056/nejm198411153112004 · Cited by 622
10.1016/b978-1-4160-2911-3.50026-1
(2000) · CrossRef Listing of Deleted DOIs · doi:10.1016/b978-1-4160-2911-3.50026-1 · Cited by 554
Gonadotropin-releasing hormone and its analogues
Desforges, J. F., Conn, P. M., & Crowley, W. F. (1991) · New England Journal of Medicine · doi:10.1056/nejm199101103240205 · Cited by 470
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Metadata
- Authors
- CROWLEY, W. F., COMITF, F., VALE, W., RIVIER, J., LORIAUX, D. L., & CUTLER, G. B.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1981-02
- Volume
- 52
- Issue
- 2
- Pages
- 370-372
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2087873780
- Cited by
- 274
- References
- 0
- FWCI
- 16.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THERAPEUTIC USE OF PITUITARY OESENSITIZATION WITH A LONG-ACTING LHRM AGONIST: A POTENTIAL NEW TREATMENT FOR IDIOPATHIC PRECOCIOUS PUBERTY*. https://app.cochat.ai/papers/10.1210/jcem-52-2-370
- The paper
- CROWLEY, W. F., COMITF, F., VALE, W., RIVIER, J., LORIAUX, D. L., & CUTLER, G. B. (1981). THERAPEUTIC USE OF PITUITARY OESENSITIZATION WITH A LONG-ACTING LHRM AGONIST: A POTENTIAL NEW TREATMENT FOR IDIOPATHIC PRECOCIOUS PUBERTY*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-52-2-370
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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